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<!--Section Begins--><br> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b>PRAZINON</b><b><sup>®</sup></b><b></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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injection solution |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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cestocidal for s. c./i. m. administration in dogs and cats |
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</p> |
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</div> |
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<div align="justify"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Composition</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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1 mL contains: |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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56.8 mg of praziquantel |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Adjuvants: propylene glycol, benzyl alcohol and chlorobutanol hemihydrate |
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</p> |
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</div> |
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<div align="justify"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Action</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Prazinon has high efficiency against <i>Echinococcus granulosus</i> in the intestines of dogs and cats and equal efficiency against mature and immature large Taenia After oral administration it is rapidly and almost completely resorbed from the intestines, metabolised in liver and excreted by urine and bile. Cestocidal action is based on the ability to damage the cuticule of tapeworms and cause spastic muscular paralysis. Praziquantel acts against the parasites in duodenal mucosa and against juvenile stages of echinococci buried in the crypts of Lieberkühn. Several seconds after its interaction with phospholipids and proteins of tapeworms, their cuticle is damaged and Ca<sup>++</sup> ions penetrate the parasite's cells causing contractions of the whole strobila. The parasite's resistance to digestive enzymes is lost, they die and are being digested. For this reason the whole body, scolex or proglottides of the parasite are rarely shed in the host's feces. |
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</p> |
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</div> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Indications</i></b> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Control of infestations of adult dogs and cats by mature and immature cestodes (tapeworms): <i>Echinococcus granulosus; Echinococcus multilocularis; Dipylidium caninum; Taenia hydatigena; Taenia pisiformis; Taenia taeniaeformis; Taenia serialis, Taenia multiceps; Taenia ovis; Taenia cervi; Mesocestoides spp.</i> and <i>Joyeuxiella spp.</i> |
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</p> |
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</div> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Contraindications</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Unknown. |
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</p> |
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</div> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Administration and dosage</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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The injections are given by subcutaneous or intramuscular route. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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A single dose is 0.1 mL of solution/kg of b. w., which corresponds to 5.68 mg of praziquantel/kg of b.w. The dose above 3 mL is given by subcutaneous route at two sites or intramuscularly. Intramuscular administration is preferred in the dogs over 25 kg of b. w. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Dogs and puppets |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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up to 2.5 kg of b.w. 0.25 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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2.5-5 kg of b.w. 0.5 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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6-10 kg of b.w. 1.0 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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11-20 kg of b.w. 2.0 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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21-30 kg of b.w. 3.0 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Cats and kittens |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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up to 1 kg of b.w. 0.1 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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1-2 kg of b.w. 0.2 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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2-3 kg of b.w. 0.3 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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3-4 kg of b.w. 0.4 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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4-5 kg of b.w. 0.5 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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over 5 kg of b.w. 0.6 mL |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Side effects</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Subcutaneous administration of higher doses may be painful and cause local irritation. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Warnings and precautions</i></b> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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Suckling puppets and kittens need not be given PRAZINON<sup>® </sup>injection solution given that the animals at this age are very rarely infested with tapeworms. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
867 |
|
868 |
In the suspected infestation with <i>Echinococcus</i> the solution is administered intramuscularly and in case of re-infestation the therapy should be re-instituted (approximately in 6-week intervals), especially to hunting and shepherd dogs and dogs in rural areas. It is important to notify their owners that they should not feed their dogs with the waste from slaughterhouses or with fresh meat. Prepatent period of <i>E. granulosis </i>is 40-50 days. |
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</p> |
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</div> |
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|
881 |
|
882 |
|
883 |
|
884 |
<div align="justify"> |
885 |
<p style="text-align: justify;"> |
886 |
|
887 |
|
888 |
|
889 |
</p> |
890 |
</div> |
891 |
|
892 |
|
893 |
|
894 |
|
895 |
|
896 |
|
897 |
|
898 |
|
899 |
|
900 |
|
901 |
|
902 |
|
903 |
<div align="justify"> |
904 |
<p style="text-align: justify;"> |
905 |
|
906 |
In the control of <i>Dipylidium caninum </i>it is necessary to concomitantly eradicate the fleas<i> </i>living on the animal and in its environment. <i>Dipylidium caninum </i>has a short prepatent period, which requires re-institution of therapy in 14-20 day intervals. |
907 |
|
908 |
</p> |
909 |
</div> |
910 |
|
911 |
|
912 |
|
913 |
|
914 |
|
915 |
|
916 |
|
917 |
|
918 |
|
919 |
|
920 |
|
921 |
|
922 |
<div align="justify"> |
923 |
<p style="text-align: justify;"> |
924 |
|
925 |
|
926 |
|
927 |
</p> |
928 |
</div> |
929 |
|
930 |
|
931 |
|
932 |
|
933 |
|
934 |
|
935 |
|
936 |
|
937 |
|
938 |
|
939 |
|
940 |
|
941 |
<div align="justify"> |
942 |
<p style="text-align: justify;"> |
943 |
|
944 |
Praziquantel does not act on the eggs of tapeworms. Therefore, over first 2 days after the treatment feces of the treated animals should be disposed of in a safe way (landfill or combustion). |
945 |
|
946 |
</p> |
947 |
</div> |
948 |
|
949 |
|
950 |
|
951 |
|
952 |
|
953 |
|
954 |
|
955 |
|
956 |
|
957 |
|
958 |
|
959 |
|
960 |
<div align="justify"> |
961 |
<p style="text-align: justify;"> |
962 |
|
963 |
|
964 |
|
965 |
</p> |
966 |
</div> |
967 |
|
968 |
|
969 |
|
970 |
|
971 |
|
972 |
|
973 |
|
974 |
|
975 |
|
976 |
|
977 |
|
978 |
|
979 |
<div align="left"> |
980 |
<p style="text-align: left;"> |
981 |
|
982 |
<b><i>Storage</i></b> |
983 |
|
984 |
</p> |
985 |
</div> |
986 |
|
987 |
|
988 |
|
989 |
|
990 |
|
991 |
|
992 |
|
993 |
|
994 |
|
995 |
|
996 |
|
997 |
|
998 |
<div align="justify"> |
999 |
<p style="text-align: justify;"> |
1000 |
|
1001 |
Store at the temperature up to 25°C. Keep away from children. |
1002 |
|
1003 |
</p> |
1004 |
</div> |
1005 |
|
1006 |
|
1007 |
|
1008 |
|
1009 |
|
1010 |
|
1011 |
|
1012 |
|
1013 |
|
1014 |
|
1015 |
|
1016 |
|
1017 |
<div align="justify"> |
1018 |
<p style="text-align: justify;"> |
1019 |
|
1020 |
|
1021 |
|
1022 |
</p> |
1023 |
</div> |
1024 |
|
1025 |
|
1026 |
|
1027 |
|
1028 |
|
1029 |
|
1030 |
|
1031 |
|
1032 |
|
1033 |
|
1034 |
|
1035 |
|
1036 |
<div align="justify"> |
1037 |
<p style="text-align: justify;"> |
1038 |
|
1039 |
Once opened keep at the temperature up to 15°C and use within 14 days. |
1040 |
|
1041 |
</p> |
1042 |
</div> |
1043 |
|
1044 |
|
1045 |
|
1046 |
|
1047 |
|
1048 |
|
1049 |
|
1050 |
|
1051 |
|
1052 |
|
1053 |
|
1054 |
|
1055 |
<div align="justify"> |
1056 |
<p style="text-align: justify;"> |
1057 |
|
1058 |
|
1059 |
|
1060 |
</p> |
1061 |
</div> |
1062 |
|
1063 |
|
1064 |
|
1065 |
|
1066 |
|
1067 |
|
1068 |
|
1069 |
|
1070 |
|
1071 |
|
1072 |
|
1073 |
|
1074 |
<div align="left"> |
1075 |
<p style="text-align: left;"> |
1076 |
|
1077 |
<b><i>Legal category</i></b> |
1078 |
|
1079 |
</p> |
1080 |
</div> |
1081 |
|
1082 |
|
1083 |
|
1084 |
|
1085 |
|
1086 |
|
1087 |
|
1088 |
|
1089 |
|
1090 |
|
1091 |
|
1092 |
|
1093 |
<div align="justify"> |
1094 |
<p style="text-align: justify;"> |
1095 |
|
1096 |
On prescription only. |
1097 |
|
1098 |
</p> |
1099 |
</div> |
1100 |
|
1101 |
|
1102 |
|
1103 |
|
1104 |
|
1105 |
|
1106 |
|
1107 |
|
1108 |
|
1109 |
|
1110 |
|
1111 |
|
1112 |
<div align="justify"> |
1113 |
<p style="text-align: justify;"> |
1114 |
|
1115 |
|
1116 |
|
1117 |
</p> |
1118 |
</div> |
1119 |
|
1120 |
|
1121 |
|
1122 |
|
1123 |
|
1124 |
|
1125 |
|
1126 |
|
1127 |
|
1128 |
|
1129 |
|
1130 |
|
1131 |
<div align="left"> |
1132 |
<p style="text-align: left;"> |
1133 |
|
1134 |
<b><i>Shelf life</i></b> |
1135 |
|
1136 |
</p> |
1137 |
</div> |
1138 |
|
1139 |
|
1140 |
|
1141 |
|
1142 |
|
1143 |
|
1144 |
|
1145 |
|
1146 |
|
1147 |
|
1148 |
|
1149 |
|
1150 |
<div align="justify"> |
1151 |
<p style="text-align: justify;"> |
1152 |
|
1153 |
Denoted on the packaging. |
1154 |
|
1155 |
</p> |
1156 |
</div> |
1157 |
|
1158 |
|
1159 |
|
1160 |
|
1161 |
|
1162 |
|
1163 |
|
1164 |
|
1165 |
|
1166 |
|
1167 |
|
1168 |
|
1169 |
<div align="justify"> |
1170 |
<p style="text-align: justify;"> |
1171 |
|
1172 |
|
1173 |
|
1174 |
</p> |
1175 |
</div> |
1176 |
|
1177 |
|
1178 |
|
1179 |
|
1180 |
|
1181 |
|
1182 |
|
1183 |
|
1184 |
|
1185 |
|
1186 |
|
1187 |
|
1188 |
<div align="left"> |
1189 |
<p style="text-align: left;"> |
1190 |
|
1191 |
<b><i>Manufacturer</i></b> |
1192 |
|
1193 |
</p> |
1194 |
</div> |
1195 |
|
1196 |
|
1197 |
|
1198 |
|
1199 |
|
1200 |
|
1201 |
|
1202 |
|
1203 |
|
1204 |
|
1205 |
|
1206 |
|
1207 |
<div align="justify"> |
1208 |
<p style="text-align: justify;"> |
1209 |
|
1210 |
VETERINA Animal Health Ltd., Croatia |
1211 |
|
1212 |
</p> |
1213 |
</div> |
1214 |
|
1215 |
|
1216 |
|
1217 |
|
1218 |
|
1219 |
|
1220 |
|
1221 |
|
1222 |
|
1223 |
|
1224 |
|
1225 |
|
1226 |
<div align="justify"> |
1227 |
<p style="text-align: justify;"> |
1228 |
|
1229 |
|
1230 |
|
1231 |
</p> |
1232 |
</div> |
1233 |
|
1234 |
|
1235 |
|
1236 |
|
1237 |
|
1238 |
|
1239 |
|
1240 |
|
1241 |
|
1242 |
|
1243 |
|
1244 |
|
1245 |
<div align="justify"> |
1246 |
<p style="text-align: justify;"> |
1247 |
|
1248 |
|
1249 |
|
1250 |
</p> |
1251 |
</div> |
1252 |
|
1253 |
|
1254 |
|
1255 |
|
1256 |
|
1257 |
|
1258 |
|
1259 |
|
1260 |
|
1261 |
|
1262 |
|
1263 |
|
1264 |
<div align="justify"> |
1265 |
<p style="text-align: justify;"> |
1266 |
|
1267 |
|
1268 |
|
1269 |
</p> |
1270 |
</div> |
1271 |
|
1272 |
|
1273 |
|
1274 |
|
1275 |
|
1276 |
|
1277 |
|
1278 |
|
1279 |
|
1280 |
|
1281 |
|
1282 |
|
1283 |
<div align="justify"> |
1284 |
<p style="text-align: justify;"> |
1285 |
|
1286 |
|
1287 |
|
1288 |
</p> |
1289 |
</div> |
1290 |
|
1291 |
|
1292 |
|
1293 |
|
1294 |
|
1295 |
|
1296 |
|
1297 |
|
1298 |
|
1299 |
|
1300 |
|
1301 |
|
1302 |
<div align="justify"> |
1303 |
<p style="text-align: justify;"> |
1304 |
|
1305 |
|
1306 |
|
1307 |
</p> |
1308 |
</div> |
1309 |
|
1310 |
|
1311 |
|
1312 |
|
1313 |
|
1314 |
|
1315 |
|
1316 |
|
1317 |
|
1318 |
|
1319 |
|
1320 |
|
1321 |
<div align="justify"> |
1322 |
<p style="text-align: justify;"> |
1323 |
|
1324 |
|
1325 |
|
1326 |
</p> |
1327 |
</div> |
1328 |
|
1329 |
|
1330 |
|
1331 |
|
1332 |
|
1333 |
|
1334 |
|
1335 |
|
1336 |
|
1337 |
|
1338 |
|
1339 |
|
1340 |
<div align="justify"> |
1341 |
<p style="text-align: justify;"> |
1342 |
|
1343 |
|
1344 |
|
1345 |
</p> |
1346 |
</div> |
1347 |
|
1348 |
|
1349 |
|
1350 |
|
1351 |
|
1352 |
|
1353 |
|
1354 |
|
1355 |
|
1356 |
|
1357 |
|
1358 |
|
1359 |
<div align="justify"> |
1360 |
<p style="text-align: justify;"> |
1361 |
|
1362 |
|
1363 |
|
1364 |
</p> |
1365 |
</div> |
1366 |
|
1367 |
|
1368 |
|
1369 |
|
1370 |
|
1371 |
|
1372 |
|
1373 |
|
1374 |
|
1375 |
|
1376 |
|
1377 |
|
1378 |
<div align="justify"> |
1379 |
<p style="text-align: justify;"> |
1380 |
|
1381 |
|
1382 |
|
1383 |
</p> |
1384 |
</div> |
1385 |
|
1386 |
|
1387 |
|
1388 |
|
1389 |
|
1390 |
|
1391 |
|
1392 |
|
1393 |
|
1394 |
|
1395 |
|
1396 |
|
1397 |
<div align="justify"> |
1398 |
<p style="text-align: justify;"> |
1399 |
|
1400 |
|
1401 |
|
1402 |
</p> |
1403 |
</div> |
1404 |
|
1405 |
|
1406 |
|
1407 |
|
1408 |
|
1409 |
|
1410 |
|
1411 |
|
1412 |
|
1413 |
|
1414 |
|
1415 |
|
1416 |
<div align="justify"> |
1417 |
<p style="text-align: justify;"> |
1418 |
|
1419 |
|
1420 |
|
1421 |
</p> |
1422 |
</div> |
1423 |
|
1424 |
|
1425 |
|
1426 |
|
1427 |
|
1428 |
|
1429 |
|
1430 |
|
1431 |
|
1432 |
|
1433 |
|
1434 |
|
1435 |
<div align="justify"> |
1436 |
<p style="text-align: justify;"> |
1437 |
|
1438 |
|
1439 |
|
1440 |
</p> |
1441 |
</div> |
1442 |
|
1443 |
|
1444 |
|
1445 |
|
1446 |
|
1447 |
|
1448 |
|
1449 |
|
1450 |
|
1451 |
|
1452 |
|
1453 |
|
1454 |
<div align="justify"> |
1455 |
<p style="text-align: justify;"> |
1456 |
|
1457 |
|
1458 |
|
1459 |
</p> |
1460 |
</div> |
1461 |
|
1462 |
|
1463 |
|
1464 |
|
1465 |
|
1466 |
|
1467 |
|
1468 |
|
1469 |
|
1470 |
|
1471 |
|
1472 |
|
1473 |
<div align="justify"> |
1474 |
<p style="text-align: justify;"> |
1475 |
|
1476 |
|
1477 |
|
1478 |
</p> |
1479 |
</div> |
1480 |
|
1481 |
|
1482 |
|
1483 |
|
1484 |
|
1485 |
|
1486 |
|
1487 |
|
1488 |
|
1489 |
|
1490 |
|
1491 |
|
1492 |
<div align="justify"> |
1493 |
<p style="text-align: justify;"> |
1494 |
|
1495 |
|
1496 |
|
1497 |
</p> |
1498 |
</div> |
1499 |
|
1500 |
|
1501 |
|
1502 |
|
1503 |
|
1504 |
|
1505 |
|
1506 |
|
1507 |
|
1508 |
|
1509 |
|
1510 |
|
1511 |
<div align="justify"> |
1512 |
<p style="text-align: justify;"> |
1513 |
|
1514 |
|
1515 |
|
1516 |
</p> |
1517 |
</div> |
1518 |
|
1519 |
|
1520 |
|
1521 |
|
1522 |
|
1523 |
|
1524 |
|
1525 |
|
1526 |
|
1527 |
|
1528 |
|
1529 |
|
1530 |
<div align="justify"> |
1531 |
<p style="text-align: justify;"> |
1532 |
|
1533 |
|
1534 |
|
1535 |
</p> |
1536 |
</div> |
1537 |
|
1538 |
|
1539 |
|
1540 |
|
1541 |
|
1542 |
|
1543 |
|
1544 |
|
1545 |
|
1546 |
|
1547 |
|
1548 |
|
1549 |
<div align="justify"> |
1550 |
<p style="text-align: justify;"> |
1551 |
|
1552 |
|
1553 |
|
1554 |
</p> |
1555 |
</div> |
1556 |
|
1557 |
|
1558 |
|
1559 |
|
1560 |
|
1561 |
|
1562 |
|
1563 |
|
1564 |
|
1565 |
|
1566 |
|
1567 |
|
1568 |
<div align="justify"> |
1569 |
<p style="text-align: justify;"> |
1570 |
|
1571 |
|
1572 |
|
1573 |
</p> |
1574 |
</div> |
1575 |
|
1576 |
|
1577 |
|
1578 |
|
1579 |
|
1580 |
|
1581 |
|
1582 |
|
1583 |
|
1584 |
|
1585 |
|
1586 |
|
1587 |
<div align="justify"> |
1588 |
<p style="text-align: justify;"> |
1589 |
|
1590 |
|
1591 |
|
1592 |
</p> |
1593 |
</div> |
1594 |
|
1595 |
|
1596 |
|
1597 |
|
1598 |
|
1599 |
|
1600 |
|
1601 |
|
1602 |
|
1603 |
|
1604 |
|
1605 |
|
1606 |
<div align="justify"> |
1607 |
<p style="text-align: justify;"> |
1608 |
|
1609 |
|
1610 |
|
1611 |
</p> |
1612 |
</div> |
1613 |
|
1614 |
|
1615 |
|
1616 |
|
1617 |
|
1618 |
|
1619 |
|
1620 |
|
1621 |
|
1622 |
|
1623 |
|
1624 |
|
1625 |
<div align="justify"> |
1626 |
<p style="text-align: justify;"> |
1627 |
|
1628 |
|
1629 |
|
1630 |
</p> |
1631 |
</div> |
1632 |
|
1633 |
|
1634 |
|
1635 |
|
1636 |
|
1637 |
|
1638 |
|
1639 |
|
1640 |
|
1641 |
|
1642 |
|
1643 |
|
1644 |
<div align="justify"> |
1645 |
<p style="text-align: justify;"> |
1646 |
|
1647 |
|
1648 |
|
1649 |
</p> |
1650 |
</div> |
1651 |
|
1652 |
|
1653 |
|
1654 |
|
1655 |
|
1656 |
|
1657 |
|
1658 |
<!--Section Ends--> |
1659 |
|
1660 |
|
1661 |
|
1662 |
|
1663 |
|
1664 |
|
1665 |
|
1666 |
|