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1 dpavlin 1.1 50 PLIVA and Microsoft sign global purchasing agreement</a></b><br>
2     <i>Zagreb, 18 January 2001.</i><br>
3     PLIVA and Microsoft signed the Microsoft Enterprise
4     Agreement - an agreement lasting several years which enables PLIVA to standardise
5     Microsoft technology on its computers in facilities in Croatia and throughout Central
6     and Eastern Europe.
7    
8     49 PLIVA acquires Dominion</a></b><br>
9     <i>Zagreb, 19 December 2000.</i><br>
10     PLIVA d.d. (&quot;PLIVA&quot;) announced today that is has acquired Pharmascience UK
11     Limited, 100% owner of Dominion Pharma Limited (&quot;Dominion&quot;), for
12     a total cash consideration of GBP 3.4 million.
13    
14     48 PLIVA and Zagrebacka banka Agreement</a></b><br>
15     <i>Zagreb, 19 December 2000.</i><br>
16     PLIVA d.d. (PLIVA) and Zagrebacka banka (ZABA) today announced that they have
17     reached an agreement regarding the sale of ZABA's 2.5% equity stake in PLIVA.
18    
19     47 VETERINA d.o.o. Established</a></b><br>
20     <i>Zagreb, 8 December 2000.</i><br>
21     Based on strategic orientation to pharmaceuticals as its core business, PLIVA has
22     decided to spin off its Animal Health &amp; Agrochemicals business segment into an
23     independent company in its full ownership.
24    
25     46 Engineer from PLIVA wins golden award for innovation</a></b><br>
26     <i>Zagreb, 8 December 2000.</i><br>
27     PLIVA's employee Srecko Brkic, a mechanical engineer in Technical Operations, won
28     the golden award at the 49th World Fair of Innovation, Research and New Technologies
29     EUREKA 2000
30    
31     45 Simplified customs procedures for the company</a></b><br>
32     <i>Zagreb, 8 December 2000.</i><br>
33     Today PLIVA started implementing simplified customs procedures, granted to the company
34     as part of a pilot-project by the Customs Administration of the Republic of Croatia.
35    
36     44 PLIVA ’s R&D Day in London on November 29, 2000 Balanced Portfolio for Short, Medium and Long Term Growth</a></b><br>
37     <i>Zagreb, 29 November 2000.</i>
38    
39     43 PLIVA signs USD 85 m Credit Facility Agreement with EBRD and IFC</a></b><br>
40     <i>Zagreb, 20 November 2000.</i><br>
41     PLIVA d.d.(PLIVA) today announced that it signed a credit facility agreement
42     (The Agreement) with the European Bank for Reconstruction and Development (EBRD)
43     and the International Finance Corporation (IFC) on 17 November 2000.
44    
45     42 PLIVA's subsidiary NEVA d.o.o. obtains the ISO 14001 environmental management system certification</a></b><br>
46     <i>Zagreb, 15 November 2000.</i><br>
47     In the presence of Mr. Roland Zuvanic, Deputy Minister of Environmental Protection
48     and Zoning, and Mr. Zeljko Covic, President of the Management Board and CEO of PLIVA,
49     Mr. Leonardo Omodeo-Zorini, representative of the Norwegian certification company DNV
50     presented the certificate to NEVA's director Ms. Sanja Slunjski.
51    
52     41 Encouragement to young scientists</a></b><br>
53     <i>Zagreb, 14 November 2000.</i><br>
54     On 14 November 2000 PLIVA and the Croatian Chemical Society presented
55     the Organic Chemistry Award Vladimir Prelog for the fourth time. This year
56     the award was presented to Valerije Vrcek, Ph.D., a young scientist from
57     the Faculty of Pharmacy and Biochemistry in Zagreb.
58    
59     40 State and business delegation from Turkey visits PLIVA</a></b><br>
60     <i>Zagreb, 28 September 2000.</i><br>
61     A state and business delegation from Turkey was in an official visit to Zagreb from 26 to 28
62     September 2000. The delegation was led by Minister of Health of the Republic of Turkey, Mr. Osman Durmus.
63    
64     39 PLIVA divests Lachema's non-core operations in Blansko</a></b><br>
65     <i>Zagreb, 11 September 2000.</i><br>
66     PLIVA d.d. ('PLIVA') announced today that it has signed an agreement with Synthon s.r.o.,
67     subsidiary of the Dutch firm Synthon BV, regarding the sale of Lachema's
68     non-core operations in Blansko, Czech Republic.
69    
70    
71     38 A New Mandate for the Members of PLIVA's MB</a></b><br>
72     <i>Zagreb, 7 September 2000.</i><br>
73     As the mandates of PLIVA's Management Board members are expiring, the company's
74     Supervisory Board appointed the Management Board members for a new five-year period.
75    
76     37 PLIVA's Scientists - Heroes of Chemistry</a></b><br>
77     <i>Zagreb, 20 August 2000.</i><br>
78     The &quot;Heroes of Chemistry
79     2000&quot;ceremony was held on 20 August 2000 in Washington D.C., USA, organised
80     by the American Chemical Society (ACS), a non-profit association of American
81     chemists and chemical engineers and the largest association of scientists in the
82     world.
83    
84     36 Special Announcement</a></b><br>
85     <i>Zagreb, 18 July 2000.</i><br>
86     We would like to inform you that
87     PLIVA's annual summer holiday will last from July 24th to August 14th.
88    
89     35 PLIVA to reduce workforce by the end of 2000</a></b><br>
90     <i>Zagreb, 3 July 2000.</i><br>
91     PLIVA d.d. ('PLIVA') announced today that it will significantly reduce its total
92     workforce by the end of the year.
93    
94     34 PLIVA's Annual General Meeting</a></b><br>
95     <i>Zagreb, 8 June 2000.</i><br>
96     The General Assembly of PLIVA d.d. shareholders was held today. The PLIVA Management Board presented Company's 1999
97     operations and position, while the Supervisory Board gave a presentation on
98     their monitoring of the Company's management of affairs.
99    
100     33 PLIVA Granted License for an Anti-Fungal NCE by BAYER AG</a></b><br>
101     <i>Zagreb, 23 May 2000.</i><br>
102     PLIVA d.d. ('PLIVA') announced today that it has received a license
103     for a new chemical entity for the treatment of fungal infections from
104     BAYER AG, Germany, a compound in its final stage of pre-clinical
105     trials.
106    
107     32 Chinese Minister of Health Visits PLIVA</a></b><br>
108     <i>Zagreb, 20 May 2000.</i><br>
109     A high-level delegation headed by Mr. Zhang Wenkang, Minister of Health of
110     The People's Republic of China, is visiting Croatia. The Mr. Wenkang's
111     visit has been organised by the Croatian Ministry of Health and the
112     Chinese Embassy.
113    
114     31 Additional Stake Acquired in Lachema</a></b><br>
115     <i>Zagreb, 27 April 2000.</i><br>
116     PLIVA announced today that it has
117     signed an agreement with an institutional investor for the purchase of 26.08% of
118     the total share capital of Lachema, the Czech pharmaceutical company, for cash
119     consideration of USD 4,945,308.49.
120    
121     30 PLIVA Group 1999 Full Year Results</a><br>
122     <i>Zagreb, 23 March 2000.<br>
123     With a 26.2% growth in net
124     income to HRK 869.1 m, PLIVA achieved strong operating results in 1999,
125     despite unfavourable conditions in the surrounding region.
126    
127     29 PLIVA sells 75% stake in its Yeast Subsidiary<br>
128     </b><i>Zagreb, March 1, 2000.</i><br>
129     PLIVA d.d. ('PLIVA') announced that it has signed an
130     agreement to sell its yeast operations carried out through its Croatian
131     subsidiary SAF Kvasac d.o.o. to Cie des Levures Lesaffre, today’s world leader
132     in the production of yeast and yeast extracts.
133    
134     28 New drug forms and prices</a><br>
135     </b><i>Zagreb, 15 February 2000.</i><br>
136     The Croatian Institute
137     for Health Insurance has announced its reimbursment list as of 15 February 2000.
138     This includes five new drug forms produced by PLIVA
139    
140     27 PLIVA ups stake in PLIVA Krakow</a><br>
141     </b><i>Zagreb, December 16, 1999.</i><br>
142     PLIVA today announced that it has acquired
143     an additional 6.17 per cent share capital of PLIVA Krakow S.A. from
144     Handlowy Investments S.A., for a cash consideration of USD 16,008,726.29.
145    
146     26 Management Board Changes</a><br>
147     </b><i>Zagreb, December 9, 1999.</i><br>
148     The organisational changes resulting from the PLIVA XXI project and the
149     further internationalisation of the Company’s activities entail changes
150     in the roles and responsibilities of the members of the Management Board.
151    
152     25 Y2k Preparations</a><br>
153     <i>Zagreb, 6 December 1999.<br>
154     We at PLIVA
155     d.d. are fully aware of the need for Y2k compliance to avoid any business
156     disruption associated with computer software, hardware and embedded
157     systems that are incapable of managing dates beyond the year 1999.
158    
159     24 Lachema Acquisition Finalised</a><br>
160     </b><i>Zagreb, December 3, 1999.</i><br>
161     PLIVA today announced that the acquisition of 66,67% stake of the Czech pharmaceutical
162     company, Lachema, was completed yesterday when PLIVA Krakow, PLIVA’s
163     subsidiary paid agreed price of USD 26.5 million.
164    
165     23 PLIVA Acquires Czech Lachema</a><br>
166     <i>Zagreb, 12 November 1999.<br>
167     </i>PLIVA
168     has announced that it has signed agreements for the purchase of a 66.67%
169     stake in Lachema, the Czech pharmaceutical company, for a cash
170     consideration of USD 26.5 million from the company’s institutional
171     investors.
172    
173     22 Notice to PLIVA d.d. Shareholders</a><br>
174     <i>Zagreb, 26 October 1999.<br>
175     </i>According
176     to the decision of the General Assembly of PLIVA d.d. shareholders held on 03
177     June 1999 concerning distribution of dividends to shareholders, PLIVA d.d.
178     should pay the 1998 dividend not later than 31 December 1999.
179    
180     21 Predrag Novak Receives Phys. Chem. Award</a><br>
181     <i>Zagreb, 26 October 1999.<br>
182     The
183     award presented each year by the Croatian Chemical Society for
184     achievements in the field of physical chemistry was presented to Predrag
185     Novak, Ph.D., who works in PLIVA’s Research Institute, at a ceremony
186     held at the Rudjer Boskovic Institute on Tuesday, October 19th.
187    
188    
189     20 PLIVA Facilities Pass FDA Inspection</a><br>
190     </b><i>Zagreb, 27 October 1999.</i><br>
191     PLIVA’s new Azithromycin facility was found to be in compliance with good
192     manufacturing practice according to the Food and Drug Administration (FDA) inspection carried out
193     in mid-October of 1999.
194    
195    
196     19 Virlix® Price Approval Application at PLIVA-Krakow.</a><br>
197     <i>Zagreb, 14 October 1999.<br>
198     PLIVA Krakow has applied for price approval of the drug Virlix®
199     10mg*20tab. (cetirizine) which will replace the product Zyrtec®
200     10mg*20tab. (cetirizine) in PLIVA Krakow’s product portfolio.
201    
202     18 Successful Debt Collection and the VAT</a><br>
203     </b><i>Zagreb, 14 October 1999.</i><br>
204     As
205     a result of a restrictive sales policy and higher collection from the
206     healthcare sector, in the last three months, PLIVA has recorded a decrease
207     in receivables from the Croatian healthcare sector, from HRK 613 million
208     at the end of June 1999 to HRK 400 million to date.
209    
210     17 Vladimir Prelog Organic Chemistry Award.</a><br>
211     </b><i>Zagreb, 14 October 1999.</i><br>
212     The “Vladimir Prelog Organic Chemistry Award” was established in 1996 as a
213     means to encourage young Croatian scientists in the field of organic
214     chemistry. Its founders were PLIVA d.d. and the Croatian Chemical Society.
215    
216     16 PLIVA CEO, Zeljko Covic, named 1999 Emerging Markets CEO of the Year</a><br>
217     </b><i>Zagreb, 28 September 1999.<br>
218     The selection Committee for the 1999 Emerging Markets CEO of the Year
219     Awards has selected Zeljko Covic, President of PLIVA's Management
220     Board, and PLIVA, as the Europe, Middle East and Africa Award
221     winner.
222     15 PLIVA GROUP RESULTS FOR 1H 1999.</a><br>
223     <i>Zagreb, 16 September, 1999.</i><br>
224     Despite challenges in the operating environment (Kosovo crisis,
225     the introduction of<span style="mso-spacerun: yes">&nbsp; </span>a
226     reference price system and illiquidity in the Croatian health-care
227     sector, introduction of a new health-care system in Poland and the
228     continuation of the Russian crisis), PLIVA achieved good results in
229     the first six months.
230     14 Organisational Changes</a></b><br>
231     <i>Zagreb, 1st July 1999.</i><br>
232     In response to changes in the environment, and with the aim
233     of generating long-term growth, PLIVA has defined a new strategy
234     within the activities of its PLIVA XXI project. The strategy is
235     based on pharmaceuticals being the core-business, continuously
236     increasing R&amp;D investments and intensifying the
237     internationalisation of the company.
238     13 Continued Strong Growth of Zithromax (Azithromycin) Sales</a><br>
239     </b><i>Zagreb, 20th April 1999.</i><b><br>
240     </b>&quot;Global sales of Zithromax (azithromycin), a broad-spectrum
241     oral antibiotic increased by 44 percent to US$ 441 million in the
242     first quarter of 1999&quot;, Pfizer reported last week. &quot;Growth
243     in sales resulted form physicians' increasing recognition of the
244     product's broad efficacy, compliance advantages, favourable
245     side-effect profile and, in liquid formulation for children, a
246     pleasant taste. Zithromax continues to be the most prescribed
247     brand-name prescription antibiotic in the U.S,&quot; added Pfizer in
248     its Press Release.
249     12 PLIVA announces acquisition of MIXIS GENETICS Ltd.</a><br>
250     </b><i>Zagreb, 15th April 1999.</i><b><br>
251     </b>PLIVA, the largest pharmaceuticals company in Central and
252     Eastern Europe announces that it has acquired 100% ownership of the
253     company MIXIS GENETICS Ltd. (&quot;MIXIS&quot;) for US$ 3.3 million.
254     By this transaction PLIVA becomes the owner of several patents
255     covering break-through technologies in the field of biodiversity.
256     11 PLIVA GROUP 1998 FULL YEAR RESULTS</a><br>
257     </b><i>Zagreb, 12th April 1999.</i><b><br>
258     </b>PLIVA, the largest pharmaceuticals company in Central and
259     Eastern Europe and listed on the London and Zagreb Stock Exchanges,
260     today announces excellent full year results for the financial year
261     1998.
262     10 PLIVA AND THE ALTHEXIS COMPANY ANNOUNCE A COLLABORATION ON THE STRUCTURE-BASED DRUG DESIGN OF NOVEL BROAD SPECTRUM ANTIBIOTICS</a><br>
263     </b><i>Zagreb, 8th February 1999.</i><b><br>
264     </b>PLIVA d.d., Zagreb, Croatia and The Althexis Company, Inc.,
265     Boston, MA., USA, today announced that they have entered into a
266     collaboration to develop and commercialise novel broad spectrum
267     antibiotics using structure-based drug design (&quot;SBDD&quot;)
268     technologies. PLIVA support for the Althexis program may total $14.4
269     million over three years in research funding and milestone payments.
270     Additional future revenues to Althexis and PLIVA may result from
271     certain exclusive marketing rights each retains under the
272     collaboration agreement.
273     9 PLIVA d.d. ANNOUNCES JOINT RESEARCH VENTURE WITH GLAXO WELLCOME PLC TO FIND NEW ANTIBIOTICS TO BEAT TREATMENT RESISTANCE</a><br>
274     </b><i>Zagreb, 1st February 1999.</i><b><br>
275     </b>PLIVA, the largest pharmaceutical company from Central and
276     Eastern Europe, announces that they are today signing a Memorandum
277     of Understanding with the UK-based pharmaceutical company, Glaxo
278     Wellcome plc, for a research collaboration aimed at finding the next
279     generation of macrolide antibiotics, capable of overcoming the
280     growing problem of treatment resistance.
281     8 INTRODUCING A REFERENCE PRICE SYSTEM FOR PHARMACEUTICAL PRODUCTS IN CROATIA AND ITS INFLUENCE ON PLIVA'S BUSINESS PERFORMANCE</a><br>
282     </b><i>Zagreb, 20 January 1999.</i><b><br>
283     </b>Prompted by the Ministry of Health, the Croatian Institute for
284     Health Insurance (&quot;HZZO&quot;) has announced its intention to
285     introduce, as of 01 February 1999, a system of so-called reference
286     prices for all pharmaceutical products reimbursed by state health
287     insurance. Accordingly, PLIVA d.d. (&quot;PLIVA&quot;), the largest
288     pharmaceutical company in Croatia and leading pharmaceutical group
289     in Central and Eastern Europe, has commenced negotiations with the
290     Ministry of Health and HZZO about determining new prices of drugs.
291     7 PLIVA LAUNCHES NEW STRATEGY FOR THE 21st CENTURY</a><br>
292     </b><i>Zagreb, 17 December 1998.</i><b><br>
293     </b>PLIVA’s new vision and new strategy represents the company’s
294     response to the challenges that globalisation is setting before
295     pharmaceutical companies. At the same time, it represents an
296     adjustment to the times and circumstances which characterise this
297     industry at the end of the 90’s and will depict the trends in the
298     next decade.
299    
300     6 PLIVA TO BUY POLISH PHARMACEUTICAL COMPANY FARMACOM</a><br>
301     </strong><i>Zagreb, 14 December 1998.</i><strong><br>
302     The Memorandum of Understanding deals with PLIVA's
303     intention to purchase a 60% stake in the Polish pharmaceutical
304     company FARMACOM whose head office is situated in Krakow, Poland.
305     5 <strong>POLFA KRAKOW CHANGES NAME TO PLIVA KRAKOW</strong></a><br>
306     <i>Zagreb, 14 December 1998.</i><br>
307     POLFA Krakow’s General Assembly decided to change the name of the
308     company at its meeting held on 30 November 1998. The new name -
309     PLIVA Krakow - will be officially used after completion of legal
310     procedures dealing with the registration which will be carried out
311     at the Polish court with jurisdiction over the matter.
312    
313     4 <strong>PLIVA AND PRIVREDNA BANKA ZAGREB SIGN COMMERCIAL PAPER CONTRACT</strong></a><br>
314     <i>
315     Zagreb, 11th December 1998.</i>
316     On 11 December 1998,
317     PLIVA, the leading pharmaceutical company from Central and Eastern
318     Europe, signed a contract with Privredna banka Zagreb for issuing
319     and selling PLIVA’s commercial papers on the Croatian money
320     market. The contract defines a HRK 400 million commercial paper
321     programme.
322    
323     3 <strong>PLIVA SIGNS A USD 100 MILLION WORTH EURO-COMMERCIAL PAPER PROGRAM</strong></a><br>
324     Zagreb, 4th December 1998</i><i>.</i>
325     <br>
326     PLIVA, the largest
327     pharmaceutical company from Central and Eastern Europe signs a USD
328     100 million worth Euro-commercial paper program and gain
329     access to the debt marketIn Vienna on Friday 4 December, PLIVA
330     signed a contract with six European banks which allows it to issue
331     Euro commercial papers up to USD 100 million on the Euro market.
332     2 RESPONSE TO SPECULATION RELATING TO LEK
333     Zagreb, 5th October 1998
334     PLIVA, the largest
335     pharmaceutical company from CEE, today denied the press speculation
336     that it may be intending to make a hostile takeover bid for Lek, the
337     Slovenian pharmaceutical company based in Ljubljana.
338     1 PLIVA ACQUIRES WORLD-WIDE RIGHTS FOR A NEW COMPOUND WITH THROMBOPOIETIN-LIKE ACTIVITY
339     Zagreb, 7th September 1998.</small></i>
340     The action of the
341     compound is distinctly different from thrombopoietin and constitutes
342     a strong alternative or complement to thrombopoietin .
343    
344     0 1998 HALF YEAR RESULTS - CONTINUED STRONG PERFORMANCE<br>
345     Zagreb, 4th September 1998.
346     OPERATING PROFIT UP BY 28.6% PLIVA, the largest pharmaceutical company in Central &amp;
347     Eastern Europe, listed on the London and Zagreb Stock Exchanges,
348     today announced excellent results for the first half of 1998.
349     -1 PLIVA OPENS NEW STATE-OF-THE-ART AZITHROMYCIN PRODUCTION FACILITY</b><br>
350     </a><i>Zagreb, 4th September 1998</i><i>.</i><br>
351     PLIVA, the largest pharmaceutical company in Central
352     and Eastern Europe, announces that its new Azithromycin production
353     plant has been completed. The project worth US$ 100 million is
354     PLIVA’s biggest investment in a production site to date. A major
355     part of the investment has been financed by PLIVA’s own funds.
356     -2 PLIVA ACQUIRES YEAST FACTORY IN SLOVAKIA</b><br>
357     </a><i>Zagreb, 4th September 1998</i><i>.<br>
358     PLIVA, the largest pharmaceutical company from Central and
359     Eastern Europe, announces the acquisition of Fermenta, joint stock
360     company in Trebišov, Slovakia (&quot;Fermenta&quot;). Fermenta, the
361     second biggest Slovakian yeast producer, was purchased for a cash
362     consideration of USD 1.3 million.
363    
364     -3 SECONDARY OFFERING OF PLIVA SHARES:<br> </small><small>I</small><small><small>NSTITUTIONAL PRICE FIXED AT US$ 16.60 PER GDR</small><br> STRONG INTERNATIONAL AND DOMESTIC DEMAND SHOWN</small>
365     </b><i>Zagreb, 13th May 1998.</i><small><br>
366     The Croatian Ministry of Finance today announced the successful
367     completion of an offering of approximately 2.92 million shares
368     (which includes 12.37 million GDRs) of PLIVA
369     d.d. (“PLIVA”).
370     PLIVA
371     is the most profitable company in Croatia and the largest
372     pharmaceutical company headquarters in Central and Eastern Europe.
373     -4 PLIVA SIGNS AGREEMENT WITH WARNER-LAMBERT PHARMACEUTICAL RESEARCH TO LICENSE OUT GASTROINTESTINAL PEPTIDES
374     </b><i>Zagreb, 24th April, 1998.</i><b><br>
375    
376     PLIVA, the largest pharmaceutical company in Central and Eastern
377     Europe has signed an agreement with Parke-Davis, a division of
378     Warner-Lambert Company. The agreement gives Parke-Davis an exclusive
379     option to license PLIVA’s newly discovered gastrointestinal
380     peptides.

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