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<p style="text-align: justify; "> <b>TRIMETOSUL</b><b><sup></sup></b><b> |
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P</b> </p> |
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<p style="text-align: justify; "> predmešanica za izdelavo medicirane krme |
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<div align="Justify"> |
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<p style="text-align: justify; "> <b>Za uporabo v veterinarski medicini</b> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Sestava</b> </p> |
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<p style="text-align: justify; "> 1 kg praška vsebuje: </p> |
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<p style="text-align: justify; "> 24 g trimetoprima, </p> |
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<p style="text-align: justify; "> 120 g sulfafurazola. </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Delovanje</b> </p> |
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<p style="text-align: justify; "> Trimetosul P je potencirani sulfonamidni |
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pripravek s širokim antimikrobnim spektrom, ki pri obèutljivih mikroorganizmih |
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ovira sintezo nukleinskih kislin. Aktivni sestavini sulfafurazol in trimetoprim |
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blokirata v bakterijah in protozojih sintezo dihidrofolne in tetrahidrofolne |
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kisline v dveh zaporednih fazah. Ker delujeta sinergistièno, kombinacija |
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sulfafurazola in trimetoprima poleg bakteriostatiènega izkazuje tudi |
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baktericidni uèinek. Obe spojini namreè v kombinaciji delujeta |
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v manjših koncentracijah, kot so potrebne za uèinek vsake posamezno. |
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Uporaba potenciranih sulfonamidov zmanjšuje mo¾nost nastajanja in |
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selekcije odpornih bakterij. </p> |
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</div> |
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<p style="text-align: justify; "> Trimetosul P deluje proti številnim po |
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Gramu pozitivnim in po Gramu negativnim mikroorganizmom (streptokokom, stafilokokom, |
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diplokokom, <i>Clostridiumu perfringensu</i>, korinobakterijam, šigelam, |
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klebsielam, aktinomicetam) in je zlasti uèinkovit za zdravljenje infekcij, |
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ki jih povzroèajo <i>E. coli, Salmonella spp.</i> in <i>Pasteurella |
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spp</i>. </p> |
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</div> |
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<p style="text-align: justify; "> Obe uèinkovini se obse¾no |
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resorbirata iz prebavil in po vnosu hitro dose¾eta uèinkovito |
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raven v krvi in tkivih. Zato pripravek, razen v èrevesju, deluje protiinfekcijsko |
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v veèini organov. </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Indikacije</b> </p> |
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<p style="text-align: justify; "> Zdravljenje primarnih in sekundarnih bakterijskih |
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infekcij, prepreèevanje posledic stresa pri odstavitvi, prevozu, spremembi |
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namestitve, prehrane idr. </p> |
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<p style="text-align: justify; "> <i>Prašièi:</i> kolibaciloza, salmoneloza, |
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atrofièni rinitis, vnetje pljuè, ki ga povzroèajo mikroorganizmi, |
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obèutljivi za potencirane sulfonamide, sindrom MMA pri plemenskih |
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svinjah (nujno je dodatno parenteralno zdravljenje), sistemske bakterijske |
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infekcije in druge bolezni. </p> |
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<p style="text-align: justify; "> <i>Teleta/junci:</i> bakterijski enteritisi |
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(<i>E. coli, Salmonella spp.</i>), nekrobaciloza, prepreèevanje enzootiène |
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bronhopnevmonije (<i>Pasteurella spp.</i>), infekcije parkljev in druge bolezni. |
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</p> |
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<p style="text-align: justify; "> <i>Perutnina:</i> bolezni, katerih povzroèitelji |
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so obèutljivi za potencirane sulfonamide (<i>E. coli, Salmonella spp., |
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Pasteurella spp.</i> idr.). </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Kontraindikacije</b> </p> |
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<p style="text-align: justify; "> ®ivali s hudimi jetrnimi in ledviènimi |
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okvarami ne smemo zdraviti s Trimetosulom P. </p> |
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<p style="text-align: justify; "> Ne smemo ga dajati ¾ivalim, pri |
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katerih so predhodno ugotovili preobèutljivostno reakcijo proti potenciranim |
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sulfonamidom, kar pa je v praksi skoraj neznano. </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Naèin uporabe</b> </p> |
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<p style="text-align: justify; "> Trimetosul P dajemo umešan v hrano, 5 |
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dni zapored. </p> |
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<p style="text-align: justify; "> Za prepreèevanje posledic stresa |
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dajemo Trimetosul P prašièem 2 dni pred odstavitvijo in 3 dni po |
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njej. </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> Pri hujših obolenjih je to zdravilo dovoljeno |
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in potrebno dajati tudi veè kot 5 dni. </p> |
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<p style="text-align: justify; "> Èe je potrebno, lahko zdravljenje |
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s Trimetosulom P ponovimo po enotedenskem presledku. </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Odmerki</b> </p> |
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<p style="text-align: justify; "> <i>Teleta:</i> 1,5 % v hrani (1,5 kg Trimetosula |
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P homogeno umešamo v 100 kg hrane). </p> |
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<p style="text-align: justify; "> <i>Prašièi:</i> 0,5 % v hrani (0,5 |
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kg Trimetosula P homogeno umešamo v 100 kg hrane). </p> |
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</div> |
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<p style="text-align: justify; "> <i>Perutnina:</i> 0,2 % v hrani (0,2 kg |
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Trimetosula P homogeno umešamo v 100 kg hrane). </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Stranski uèinki</b> </p> |
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<p style="text-align: justify; "> Niso znani. </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Opozorila in varnostni ukrepi</b> </p> |
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<p style="text-align: justify; "> Bolne ¾ivali, ki slabo in nezadostno |
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jedo hrano, je treba zdraviti parenteralno (npr. z injekcijsko suspenzijo |
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Trimetosul 48 %). </p> |
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</div> |
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<p style="text-align: justify; "> ®ivali, hranjene z mešanico, v katero |
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je umešan Trimetosul P, med zdravljenjem ne smejo imeti dostopa do drugih |
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virov hrane. </p> |
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</div> |
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<p style="text-align: justify; "> Da bi med zdravljenjem zmanjšali morebitne |
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ledviène okvare zaradi kristalinurije, morajo imeti ¾ivali |
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nemoten dostop do pitne vode. </p> |
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</div> |
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<p style="text-align: justify; "> Podaljšana uporaba veèjih odmerkov |
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sulfonamida lahko v pred¾elodcih pre¾vekovalcev zmanjša razgradnjo |
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celuloze. </p> |
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<p style="text-align: justify; "> Sulfonamidi redko lahko zmanjšajo valjenje |
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oz. upoèasnijo prirast pitanih pišèancev. </p> |
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</div> |
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<p style="text-align: justify; "> Ni priporoèljivo soèasno |
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mešanje Trimetosula P v hrani z drugimi zdravili ali zdravilnimi dodatki. |
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</p> |
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</div> |
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<p style="text-align: justify; "> Kot pri delu z drugimi antimikrobnimi |
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zdravili mora osebje, ki umešava Trimetosul P v ¾ivinsko hrano, nositi |
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zašèitno masko in rokavice, t. j. izogibati se mora stiku zdravilne |
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predmešanice s ko¾o in sluznicami. Po delu se morajo delavci temeljito |
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umiti. </p> |
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</div> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Karenca</b> </p> |
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</div> |
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<p style="text-align: justify; "> Meso<b> </b>telet in prašièev: |
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8 dni </p> |
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</div> |
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<p style="text-align: justify; "> Meso perutnine: 4 dni </p> |
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</div> |
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<p style="text-align: justify; "> Jajca<b>:</b> 10 dni </p> |
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</div> |
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<p style="text-align: justify; "> <b></b> </p> |
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<p style="text-align: justify; "> Rok uporabnosti </p> |
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</div> |
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<p style="text-align: justify; "> Oznaèen je na ovojnini (18 mesecev). |
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</p> |
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</div> |
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<p style="text-align: justify; "> Hrano z umešanim Trimetosulom P je treba |
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porabiti v 3 mesecih. </p> |
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</div> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Naèin izdajanja</b> </p> |
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</div> |
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<p style="text-align: justify; "> Na recept. </p> |
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<p style="text-align: justify; "> </p> |
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</div> |
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<p style="text-align: justify; "> <b>Naèin shranjevanja</b> </p> |
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</div> |
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<div align="Justify"> |
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<p style="text-align: justify; "> Shranite zašèiteno pred vlago, |
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pri temperaturi do 25 <sup>o</sup>C in nedosegljivo otrokom. </p> |
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</div> |
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<div align="Justify"> |
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<p style="text-align: justify; "> </p> |
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</div> |
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<div align="Justify"> |
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<p style="text-align: justify; "> <b>Številka in datum odloèbe </b> |
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</p> |
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</div> |
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<p style="text-align: justify; "> 323-03-8/00-129, 21.05.2001 </p> |
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<div align="Justify"> |
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<p style="text-align: justify; "> <b></b> </p> |
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<p style="text-align: justify; "> Oprema </p> |
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<p style="text-align: justify; "> Veèplastna natronska vreèa |
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s polietilensko folijo s 25 kg predmešanice </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> <b>Postopek s prazno ovojnino</b> </p> |
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<p style="text-align: justify; "> Prazne ovojnine ne smemo odvreèi |
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med obièajne komunalne odpadke. </p> |
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<p style="text-align: justify; "> <b>Proizvajalec</b> </p> |
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<p style="text-align: justify; "> VETERINA d.o.o., HRVAŠKA </p> |
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<p style="text-align: justify; "> <b>Zastopnik</b> </p> |
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<p style="text-align: justify; "> PLIVA LJUBLJANA d. o. o., SLOVENIJA </p> |
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<p style="text-align: justify; "> </p> |
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<p style="text-align: justify; "> Revidirano na seji Komisije za registracijo |
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zdravil za uporabo v veterinarski medicini dne 18.12.2000. </p> |
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