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Revision 1.2 - (show annotations)
Tue Apr 10 11:02:11 2001 UTC (18 years, 6 months ago) by dpavlin
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1
2
3 <!--Section Begins--><br>
4
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8
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10 <div align="justify">
11 <p style="text-align: justify;">
12
13 <b>PRAZINON</b><b><sup> </sup></b><b><sup>®</sup></b><b> plus </b>
14
15 </p>
16 </div>
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18
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24
25
26
27
28
29 <div align="justify">
30 <p style="text-align: justify;">
31
32 tablet for dogs
33
34 </p>
35 </div>
36
37
38
39
40
41
42
43
44
45
46
47
48 <div align="justify">
49 <p style="text-align: justify;">
50
51
52
53 </p>
54 </div>
55
56
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60
61
62
63
64
65
66
67 <div align="left">
68 <p style="text-align: left;">
69
70 <b><i>Composition</i></b>
71
72 </p>
73 </div>
74
75
76
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80
81
82
83
84
85
86 <div align="justify">
87 <p style="text-align: justify;">
88
89 1 tablet contains:
90
91 </p>
92 </div>
93
94
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96
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98
99
100
101
102
103
104
105 <div align="justify">
106 <p style="text-align: justify;">
107
108 50 mg of praziquantel
109
110 </p>
111 </div>
112
113
114
115
116
117
118
119
120
121
122
123
124 <div align="justify">
125 <p style="text-align: justify;">
126
127 144 mg of pyrantel pamoate
128
129 </p>
130 </div>
131
132
133
134
135
136
137
138
139
140
141
142
143 <div align="justify">
144 <p style="text-align: justify;">
145
146 150 mg of febantel
147
148 </p>
149 </div>
150
151
152
153
154
155
156
157
158
159
160
161
162 <div align="justify">
163 <p style="text-align: justify;">
164
165 Adjuvants: lactose, maize starch, copolividon, sodium lauryl sulphate, cellulose microcrystalline, highly dispersible silicium dioxide, hydrogenated vegetable oil, talc and magnesium stearate.
166
167 </p>
168 </div>
169
170
171
172
173
174
175
176
177
178
179
180
181 <div align="justify">
182 <p style="text-align: justify;">
183
184
185
186 </p>
187 </div>
188
189
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195
196
197
198
199
200 <div align="left">
201 <p style="text-align: left;">
202
203 <b><i>Action</i></b>
204
205 </p>
206 </div>
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217
218
219 <div align="justify">
220 <p style="text-align: justify;">
221
222 Three active ingredients that do not interfere in their action but rather act individually ensure a broad-spectrum anthelmintic action of the tablets.
223
224 </p>
225 </div>
226
227
228
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231
232
233
234
235
236
237
238 <div align="justify">
239 <p style="text-align: justify;">
240
241
242
243 </p>
244 </div>
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250
251
252
253
254
255
256
257 <div align="justify">
258 <p style="text-align: justify;">
259
260 Praziquantel acts cestocidally, against mature and immature tapeworms (cestodes). After oral administration it is rapidly and almost completely resorbed from the intestines, metabolised in the liver and excreted by urine and bile. Cestocidal action is based on the ability to damage the cuticle of tapeworms and cause spastic muscular paralysis. Praziquantel acts against the parasites in duodenal mucosa and against juvenile stages of echinococci buried in the crypts of Lieberkühn. Several seconds after its interaction with phospholipids and proteins of tapeworms, their cuticle is damaged and Ca<b><sup>++</sup></b> ions penetrate the parasite's cells causing contractions of the whole strobila. The parasites' resistance to digestive enzymes is lost, they die and are being digested. For this reason the host's feces rarely contain the whole body, scolex or proglottides the parasite.
261
262 </p>
263 </div>
264
265
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269
270
271
272
273
274
275
276 <div align="justify">
277 <p style="text-align: justify;">
278
279
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281 </p>
282 </div>
283
284
285
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289
290
291
292
293
294
295 <div align="justify">
296 <p style="text-align: justify;">
297
298 Pyrantel pamoate acts against many roundworms (nematodes) where it inhibits neuromuscular transmission of impulses, thus causing spastic paralysis of their muscles. Peristalsis of the host's intestines helps excrete dead parasites.
299
300 </p>
301 </div>
302
303
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307
308
309
310
311
312
313
314 <div align="justify">
315 <p style="text-align: justify;">
316
317
318
319 </p>
320 </div>
321
322
323
324
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326
327
328
329
330
331
332
333 <div align="justify">
334 <p style="text-align: justify;">
335
336 Febantel is probenzimidazole which is in the liver of dogs transformed into active metabolites of oxfendazole and fenbendazole. In the enterocytes and cuticle of the parasites they bind to the structural protein turbulin, preventing polymerisation of microtubuli indispensable in the transport system of the resorption cells and, thus, leading to autolysis of nematodes. Pyrantel and febantel do not act synergistically.
337
338 </p>
339 </div>
340
341
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345
346
347
348
349
350
351
352 <div align="justify">
353 <p style="text-align: justify;">
354
355
356
357 </p>
358 </div>
359
360
361
362
363
364
365
366
367
368
369
370
371 <div align="left">
372 <p style="text-align: left;">
373
374 <b><i>Indications</i></b>
375
376 </p>
377 </div>
378
379
380
381
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383
384
385
386
387
388
389
390 <div align="justify">
391 <p style="text-align: justify;">
392
393 Control of infestation of adult dogs and puppets with nematodes (roundworms) and cestodes (tapeworms), in particular:
394
395 </p>
396 </div>
397
398
399
400
401
402
403
404
405
406
407 <ul>
408 <li>
409
410 <div align="justify">
411 <p style="text-align: justify;">
412
413 nematodes: <i>Toxocara canis; Toxascaris leonina; Uncinaria stenocephala; Ancylostoma caninum</i> and <i>Trichuris vulpis</i>;
414
415 </p>
416 </div>
417
418
419
420
421
422
423
424
425
426
427 <li>
428
429 <div align="justify">
430 <p style="text-align: justify;">
431
432 cestodes: <i>Echinococcus granulosus; Echinococcus multilocularis; Dipylidium caninum; Taenia hydatigena; Taenia pisiformis; Taenia taeniaeformis; Taenia serialis, Taenia multiceps; Taenia ovis; Taenia cervi; Mesocestoides spp.</i> and <i>Joyeuxiella spp.</i>
433
434 </p>
435 </div>
436
437
438
439
440
441
442
443
444
445
446 </ul>
447
448 <div align="justify">
449 <p style="text-align: justify;">
450
451
452
453 </p>
454 </div>
455
456
457
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459
460
461
462
463
464
465
466
467 <div align="left">
468 <p style="text-align: left;">
469
470 <b><i>Contraindications</i></b>
471
472 </p>
473 </div>
474
475
476
477
478
479
480
481
482
483
484
485
486 <div align="justify">
487 <p style="text-align: justify;">
488
489 First 40 days of gravity.
490
491 </p>
492 </div>
493
494
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500
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502
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504
505 <div align="justify">
506 <p style="text-align: justify;">
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510 </p>
511 </div>
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518
519
520
521
522
523
524 <div align="left">
525 <p style="text-align: left;">
526
527 <b><i>Administration and dosage</i></b>
528
529 </p>
530 </div>
531
532
533
534
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537
538
539
540
541
542
543 <div align="justify">
544 <p style="text-align: justify;">
545
546 The tablets are given alone or mixed with food (chopped meat, cheese, etc.), preferably before the meal. It is not necessary to restrict the animals from food beforehand.
547
548 </p>
549 </div>
550
551
552
553
554
555
556
557
558
559
560
561
562 <div align="justify">
563 <p style="text-align: justify;">
564
565
566
567 </p>
568 </div>
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577
578
579
580
581 <div align="justify">
582 <p style="text-align: justify;">
583
584 The dose is 1 tablet/10 kg of b.w. once daily (i. e. 5 mg of praziquantel, 14.4 mg of pyrantel pamoate and 15 mg of febantel per kg of b.w.).
585
586 </p>
587 </div>
588
589
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594
595
596
597
598
599
600 <div align="justify">
601 <p style="text-align: justify;">
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603
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605 </p>
606 </div>
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614
615
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617
618
619 <div align="justify">
620 <p style="text-align: justify;">
621
622 For regular dehelminthisation it is recommended to repeat the treatment every 3 months. In severe infestation re-institute the drug after 14 days.
623
624 </p>
625 </div>
626
627
628
629
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632
633
634
635
636
637
638 <div align="justify">
639 <p style="text-align: justify;">
640
641
642
643 </p>
644 </div>
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653
654
655
656
657 <div align="justify">
658 <p style="text-align: justify;">
659
660 Puppets and small dogs:
661
662 </p>
663 </div>
664
665
666
667
668
669
670
671
672
673
674
675
676 <div align="justify">
677 <p style="text-align: justify;">
678
679 0.5-2 kg of b.w. 1/4 tablet
680
681 </p>
682 </div>
683
684
685
686
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688
689
690
691
692
693
694
695 <div align="justify">
696 <p style="text-align: justify;">
697
698 2 - 5 kg of b.w. 1/2 tablet
699
700 </p>
701 </div>
702
703
704
705
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707
708
709
710
711
712
713
714 <div align="justify">
715 <p style="text-align: justify;">
716
717 5-10 kg of b.w. 1 tablet
718
719 </p>
720 </div>
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727
728
729
730
731
732
733 <div align="justify">
734 <p style="text-align: justify;">
735
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737
738 </p>
739 </div>
740
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747
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749
750
751
752 <div align="justify">
753 <p style="text-align: justify;">
754
755 Medium-size dogs:
756
757 </p>
758 </div>
759
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764
765
766
767
768
769
770
771 <div align="justify">
772 <p style="text-align: justify;">
773
774 10-20 kg of b.w. 2 tablets
775
776 </p>
777 </div>
778
779
780
781
782
783
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785
786
787
788
789
790 <div align="justify">
791 <p style="text-align: justify;">
792
793 20-30 kg of b.w. 3 tablets
794
795 </p>
796 </div>
797
798
799
800
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802
803
804
805
806
807
808
809 <div align="justify">
810 <p style="text-align: justify;">
811
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814 </p>
815 </div>
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825
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828 <div align="justify">
829 <p style="text-align: justify;">
830
831 Large dogs:
832
833 </p>
834 </div>
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846
847 <div align="justify">
848 <p style="text-align: justify;">
849
850 30-40 kg of b.w. 4 tablets
851
852 </p>
853 </div>
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865
866 <div align="justify">
867 <p style="text-align: justify;">
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870
871 </p>
872 </div>
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884
885 <div align="justify">
886 <p style="text-align: justify;">
887
888 Given that puppets may be infested by tapeworms only after 3<sup>rd</sup> week of life, Prazinon<sup>®</sup> plus may be given after this period if mixed infestation with roundworms and tapeworms is established. It is recommended to perform regular dehelminthisation of dogs prior to vaccination.
889
890 </p>
891 </div>
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904 <div align="justify">
905 <p style="text-align: justify;">
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909 </p>
910 </div>
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923 <div align="left">
924 <p style="text-align: left;">
925
926 <b><i>Side effects</i></b>
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928 </p>
929 </div>
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940
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942 <div align="justify">
943 <p style="text-align: justify;">
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945 Unknown.
946
947 </p>
948 </div>
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961 <div align="justify">
962 <p style="text-align: justify;">
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966 </p>
967 </div>
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978
979
980 <div align="left">
981 <p style="text-align: left;">
982
983 <b><i>Warnings and precautions</i></b>
984
985 </p>
986 </div>
987
988
989
990
991
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993
994
995
996
997
998
999 <div align="justify">
1000 <p style="text-align: justify;">
1001
1002 Care should be exercised when administering preparations containing pyrantel to very weak animals. Praziquantel does not act on the eggs of tapeworms. Therefore, over first 2 days after the treatment feces of the treated animals should be disposed of in a safe way (landfill or combustion).
1003
1004 </p>
1005 </div>
1006
1007
1008
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1016
1017
1018 <div align="justify">
1019 <p style="text-align: justify;">
1020
1021
1022
1023 </p>
1024 </div>
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1034
1035
1036
1037 <div align="justify">
1038 <p style="text-align: justify;">
1039
1040 Given that fleas serve as intermediate hosts to <i>D. caninum</i> tapeworm, dehelminthisation programme should include concomitant extermination of fleas.
1041
1042 </p>
1043 </div>
1044
1045
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1051
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1053
1054
1055
1056 <div align="justify">
1057 <p style="text-align: justify;">
1058
1059
1060
1061 </p>
1062 </div>
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1064
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1070
1071
1072
1073
1074
1075 <div align="justify">
1076 <p style="text-align: justify;">
1077
1078 Do not exceed the recommended dose, particularly when treating pregnant bitches.
1079
1080 </p>
1081 </div>
1082
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1089
1090
1091
1092
1093
1094 <div align="justify">
1095 <p style="text-align: justify;">
1096
1097
1098
1099 </p>
1100 </div>
1101
1102
1103
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1107
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1109
1110
1111
1112
1113 <div align="left">
1114 <p style="text-align: left;">
1115
1116 <b><i>Storage</i></b>
1117
1118 </p>
1119 </div>
1120
1121
1122
1123
1124
1125
1126
1127
1128
1129
1130
1131
1132 <div align="justify">
1133 <p style="text-align: justify;">
1134
1135 Store at the temperature up to 25°C. Keep away from children.
1136
1137 </p>
1138 </div>
1139
1140
1141
1142
1143
1144
1145
1146
1147
1148
1149
1150
1151 <div align="justify">
1152 <p style="text-align: justify;">
1153
1154
1155
1156 </p>
1157 </div>
1158
1159
1160
1161
1162
1163
1164
1165
1166
1167
1168
1169
1170 <div align="left">
1171 <p style="text-align: left;">
1172
1173 <b><i>Legal category</i></b>
1174
1175 </p>
1176 </div>
1177
1178
1179
1180
1181
1182
1183
1184
1185
1186
1187
1188
1189 <div align="justify">
1190 <p style="text-align: justify;">
1191
1192 OTC
1193
1194 </p>
1195 </div>
1196
1197
1198
1199
1200
1201
1202
1203
1204
1205
1206
1207
1208 <div align="justify">
1209 <p style="text-align: justify;">
1210
1211
1212
1213 </p>
1214 </div>
1215
1216
1217
1218
1219
1220
1221
1222
1223
1224
1225
1226
1227 <div align="left">
1228 <p style="text-align: left;">
1229
1230 <b><i>Shelf life</i></b>
1231
1232 </p>
1233 </div>
1234
1235
1236
1237
1238
1239
1240
1241
1242
1243
1244
1245
1246 <div align="justify">
1247 <p style="text-align: justify;">
1248
1249 Denoted on the packaging.
1250
1251 </p>
1252 </div>
1253
1254
1255
1256
1257
1258
1259
1260
1261
1262
1263
1264
1265 <div align="justify">
1266 <p style="text-align: justify;">
1267
1268
1269
1270 </p>
1271 </div>
1272
1273
1274
1275
1276
1277
1278
1279
1280
1281
1282
1283
1284 <div align="left">
1285 <p style="text-align: left;">
1286
1287 <b><i>Manufacturer</i></b>
1288
1289 </p>
1290 </div>
1291
1292
1293
1294
1295
1296
1297
1298
1299
1300
1301
1302
1303 <div align="justify">
1304 <p style="text-align: justify;">
1305
1306 VETERINA Animal Health Ltd., Croatia
1307
1308 </p>
1309 </div>
1310
1311
1312
1313
1314
1315
1316
1317 <!--Section Ends-->
1318
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