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dpavlin |
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<!--Section Begins--><br> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b>TRIMETOSUL</b><b><sup>®</sup></b><b> P</b> |
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</p> |
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</div> |
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<div align="justify"> |
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<i>medicated additive</i> |
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</p> |
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<div align="justify"> |
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<b><i>Composition</i></b> |
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</p> |
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1 kg contains: |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Trimethoprim 24 g |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Sulfafurazole 120 g |
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</p> |
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Carrier and adjuvants up to 1000 g |
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</p> |
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</p> |
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</div> |
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<b><i>Action</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Trimetosul<b><sup>®</sup></b> P is a potentiated sulfonamide preparation of a broad antimicrobial action, which in the sensitive organisms interferes with the synthesis of nucleic acids. Its active ingredients, sulfafurazole and trimethoprim, inhibit in two consecutive steps bacterial and protozoal synthesis of folic acid. Given their synergistic action, in addition to bacteriostatic effect, they exert bactericidal as well. Combination of these two ingredients ensures desired effect of lower doses than required for each of them separately. Potentiated sulfonamides reduce the risk of resistance. |
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</p> |
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</div> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Trimetosul<b><sup>®</sup></b> P acts against many gram-positive and gram-negative organisms (streptococci, staphylococci, diplococci, <i>Clostridium perfringens</i>, Corynebacteria, shigellae, klebsiellae and actinomycetae) and is particularly effective in the management of <i>E.</i> <i>coli</i>, <i>Salmonella</i> spp, and <i>Pasteurella</i> spp. infections. |
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</p> |
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</div> |
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</p> |
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However, potentiated combinations of sulfonamide and trimethoprim are not efficient against mycoplasma, rickettsiae and spirochetes (<i>Serpulina</i> <i>hyodysenteriae</i>, <i>Leptospira</i> spp.), <i>Pseudomonas</i> <i>aeruginosa</i> and <i>Erysipelothrix</i> <i>insidiosa</i>. |
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</p> |
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</p> |
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Active ingredients are extensively resorbed from gastrointestinal tract and rapidly achieve effective blood- and tissue-levels. Therefore, they are equally effective in the intestines and the organs. |
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</p> |
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<b><i>Indications</i></b> |
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Treatment of primary and secondary bacterial infections; prevention of stress conditions following weaning, transportation, change of housing, feed, etc. |
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</p> |
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</div> |
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</p> |
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<i>Swine:</i> |
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</p> |
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</div> |
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Colibacillosis, salmonellosis, atrophic rhinitis, pneumonia caused by the organisms sensitive to potentiated sulfonamides, MMA syndrome in sows (supportive parenteral treatment is necessary), systemic bacterial infections and other diseases. |
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</p> |
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</div> |
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</p> |
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<i>Calves-heifers:</i> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Bacterial enteritis (<i>E.</i> <i>coli</i>, <i>Salmonella spp.</i>), necrobacillosis, prophylaxis of enzootic bronchopneumonia (<i>Pasteurella</i> spp.), supportive treatment of umbilical infection, etc. |
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</p> |
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</div> |
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</p> |
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</div> |
530 |
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|
|
531 |
|
|
|
532 |
|
|
|
533 |
|
|
|
534 |
|
|
|
535 |
|
|
|
536 |
|
|
|
537 |
|
|
|
538 |
|
|
|
539 |
|
|
|
540 |
|
|
|
541 |
|
|
|
542 |
|
|
<div align="justify"> |
543 |
|
|
<p style="text-align: justify;"> |
544 |
|
|
|
545 |
|
|
<i>Poultry:</i> |
546 |
|
|
|
547 |
|
|
</p> |
548 |
|
|
</div> |
549 |
|
|
|
550 |
|
|
|
551 |
|
|
|
552 |
|
|
|
553 |
|
|
|
554 |
|
|
|
555 |
|
|
|
556 |
|
|
|
557 |
|
|
|
558 |
|
|
|
559 |
|
|
|
560 |
|
|
|
561 |
|
|
<div align="justify"> |
562 |
|
|
<p style="text-align: justify;"> |
563 |
|
|
|
564 |
|
|
Diseases caused by the bacteria sensitive to potentiated sulfonamides (<i>E.</i> <i>coli</i>, <i>Salmonella</i> spp., <i>Pasteurella</i> spp. etc.). |
565 |
|
|
|
566 |
|
|
</p> |
567 |
|
|
</div> |
568 |
|
|
|
569 |
|
|
|
570 |
|
|
|
571 |
|
|
|
572 |
|
|
|
573 |
|
|
|
574 |
|
|
|
575 |
|
|
|
576 |
|
|
|
577 |
|
|
|
578 |
|
|
|
579 |
|
|
|
580 |
|
|
<div align="justify"> |
581 |
|
|
<p style="text-align: justify;"> |
582 |
|
|
|
583 |
|
|
<b></b> |
584 |
|
|
|
585 |
|
|
</p> |
586 |
|
|
</div> |
587 |
|
|
|
588 |
|
|
|
589 |
|
|
|
590 |
|
|
|
591 |
|
|
|
592 |
|
|
|
593 |
|
|
|
594 |
|
|
|
595 |
|
|
|
596 |
|
|
|
597 |
|
|
|
598 |
|
|
|
599 |
|
|
<div align="justify"> |
600 |
|
|
<p style="text-align: justify;"> |
601 |
|
|
|
602 |
|
|
<b><i>Contraindications</i></b><b></b> |
603 |
|
|
|
604 |
|
|
</p> |
605 |
|
|
</div> |
606 |
|
|
|
607 |
|
|
|
608 |
|
|
|
609 |
|
|
|
610 |
|
|
|
611 |
|
|
|
612 |
|
|
|
613 |
|
|
|
614 |
|
|
|
615 |
|
|
|
616 |
|
|
|
617 |
|
|
|
618 |
|
|
<div align="justify"> |
619 |
|
|
<p style="text-align: justify;"> |
620 |
|
|
|
621 |
|
|
Severe hepatic and renal impairment. |
622 |
|
|
|
623 |
|
|
</p> |
624 |
|
|
</div> |
625 |
|
|
|
626 |
|
|
|
627 |
|
|
|
628 |
|
|
|
629 |
|
|
|
630 |
|
|
|
631 |
|
|
|
632 |
|
|
|
633 |
|
|
|
634 |
|
|
|
635 |
|
|
|
636 |
|
|
|
637 |
|
|
<div align="justify"> |
638 |
|
|
<p style="text-align: justify;"> |
639 |
|
|
|
640 |
|
|
|
641 |
|
|
|
642 |
|
|
</p> |
643 |
|
|
</div> |
644 |
|
|
|
645 |
|
|
|
646 |
|
|
|
647 |
|
|
|
648 |
|
|
|
649 |
|
|
|
650 |
|
|
|
651 |
|
|
|
652 |
|
|
|
653 |
|
|
|
654 |
|
|
|
655 |
|
|
|
656 |
|
|
<div align="justify"> |
657 |
|
|
<p style="text-align: justify;"> |
658 |
|
|
|
659 |
|
|
Trimethoprim/sulfonamide combinations are contraindicated in the animals with the established hypersensitivity to potentiated sulfonamides, which is extremely rare. |
660 |
|
|
|
661 |
|
|
</p> |
662 |
|
|
</div> |
663 |
|
|
|
664 |
|
|
|
665 |
|
|
|
666 |
|
|
|
667 |
|
|
|
668 |
|
|
|
669 |
|
|
|
670 |
|
|
|
671 |
|
|
|
672 |
|
|
|
673 |
|
|
|
674 |
|
|
|
675 |
|
|
<div align="justify"> |
676 |
|
|
<p style="text-align: justify;"> |
677 |
|
|
|
678 |
|
|
|
679 |
|
|
|
680 |
|
|
</p> |
681 |
|
|
</div> |
682 |
|
|
|
683 |
|
|
|
684 |
|
|
|
685 |
|
|
|
686 |
|
|
|
687 |
|
|
|
688 |
|
|
|
689 |
|
|
|
690 |
|
|
|
691 |
|
|
|
692 |
|
|
|
693 |
|
|
|
694 |
|
|
<div align="justify"> |
695 |
|
|
<p style="text-align: justify;"> |
696 |
|
|
|
697 |
|
|
<b><i>Administration</i></b><b></b> |
698 |
|
|
|
699 |
|
|
</p> |
700 |
|
|
</div> |
701 |
|
|
|
702 |
|
|
|
703 |
|
|
|
704 |
|
|
|
705 |
|
|
|
706 |
|
|
|
707 |
|
|
|
708 |
|
|
|
709 |
|
|
|
710 |
|
|
|
711 |
|
|
|
712 |
|
|
|
713 |
|
|
<div align="justify"> |
714 |
|
|
<p style="text-align: justify;"> |
715 |
|
|
|
716 |
|
|
Trimetosul<b><sup>®</sup></b> P is given with feed over 5 consecutive days. |
717 |
|
|
|
718 |
|
|
</p> |
719 |
|
|
</div> |
720 |
|
|
|
721 |
|
|
|
722 |
|
|
|
723 |
|
|
|
724 |
|
|
|
725 |
|
|
|
726 |
|
|
|
727 |
|
|
|
728 |
|
|
|
729 |
|
|
|
730 |
|
|
|
731 |
|
|
|
732 |
|
|
<div align="justify"> |
733 |
|
|
<p style="text-align: justify;"> |
734 |
|
|
|
735 |
|
|
|
736 |
|
|
|
737 |
|
|
</p> |
738 |
|
|
</div> |
739 |
|
|
|
740 |
|
|
|
741 |
|
|
|
742 |
|
|
|
743 |
|
|
|
744 |
|
|
|
745 |
|
|
|
746 |
|
|
|
747 |
|
|
|
748 |
|
|
|
749 |
|
|
|
750 |
|
|
|
751 |
|
|
<div align="justify"> |
752 |
|
|
<p style="text-align: justify;"> |
753 |
|
|
|
754 |
|
|
To prevent the outcomes of stress at weaning, Trimetosul<b><sup>®</sup></b> P is given 2 days before and 3 days after it. |
755 |
|
|
|
756 |
|
|
</p> |
757 |
|
|
</div> |
758 |
|
|
|
759 |
|
|
|
760 |
|
|
|
761 |
|
|
|
762 |
|
|
|
763 |
|
|
|
764 |
|
|
|
765 |
|
|
|
766 |
|
|
|
767 |
|
|
|
768 |
|
|
|
769 |
|
|
|
770 |
|
|
<div align="justify"> |
771 |
|
|
<p style="text-align: justify;"> |
772 |
|
|
|
773 |
|
|
|
774 |
|
|
|
775 |
|
|
</p> |
776 |
|
|
</div> |
777 |
|
|
|
778 |
|
|
|
779 |
|
|
|
780 |
|
|
|
781 |
|
|
|
782 |
|
|
|
783 |
|
|
|
784 |
|
|
|
785 |
|
|
|
786 |
|
|
|
787 |
|
|
|
788 |
|
|
|
789 |
|
|
<div align="justify"> |
790 |
|
|
<p style="text-align: justify;"> |
791 |
|
|
|
792 |
|
|
Severe conditions allow administration longer than 5 days. |
793 |
|
|
|
794 |
|
|
</p> |
795 |
|
|
</div> |
796 |
|
|
|
797 |
|
|
|
798 |
|
|
|
799 |
|
|
|
800 |
|
|
|
801 |
|
|
|
802 |
|
|
|
803 |
|
|
|
804 |
|
|
|
805 |
|
|
|
806 |
|
|
|
807 |
|
|
|
808 |
|
|
<div align="justify"> |
809 |
|
|
<p style="text-align: justify;"> |
810 |
|
|
|
811 |
|
|
|
812 |
|
|
|
813 |
|
|
</p> |
814 |
|
|
</div> |
815 |
|
|
|
816 |
|
|
|
817 |
|
|
|
818 |
|
|
|
819 |
|
|
|
820 |
|
|
|
821 |
|
|
|
822 |
|
|
|
823 |
|
|
|
824 |
|
|
|
825 |
|
|
|
826 |
|
|
|
827 |
|
|
<div align="justify"> |
828 |
|
|
<p style="text-align: justify;"> |
829 |
|
|
|
830 |
|
|
If necessary the treatment may be repeated after one week of withdrawal. |
831 |
|
|
|
832 |
|
|
</p> |
833 |
|
|
</div> |
834 |
|
|
|
835 |
|
|
|
836 |
|
|
|
837 |
|
|
|
838 |
|
|
|
839 |
|
|
|
840 |
|
|
|
841 |
|
|
|
842 |
|
|
|
843 |
|
|
|
844 |
|
|
|
845 |
|
|
|
846 |
|
|
<div align="justify"> |
847 |
|
|
<p style="text-align: justify;"> |
848 |
|
|
|
849 |
|
|
|
850 |
|
|
|
851 |
|
|
</p> |
852 |
|
|
</div> |
853 |
|
|
|
854 |
|
|
|
855 |
|
|
|
856 |
|
|
|
857 |
|
|
|
858 |
|
|
|
859 |
|
|
|
860 |
|
|
|
861 |
|
|
|
862 |
|
|
|
863 |
|
|
|
864 |
|
|
|
865 |
|
|
<div align="justify"> |
866 |
|
|
<p style="text-align: justify;"> |
867 |
|
|
|
868 |
|
|
<b><i>Dosage</i></b> |
869 |
|
|
|
870 |
|
|
</p> |
871 |
|
|
</div> |
872 |
|
|
|
873 |
|
|
|
874 |
|
|
|
875 |
|
|
|
876 |
|
|
|
877 |
|
|
|
878 |
|
|
|
879 |
|
|
|
880 |
|
|
|
881 |
|
|
|
882 |
|
|
|
883 |
|
|
|
884 |
|
|
<div align="justify"> |
885 |
|
|
<p style="text-align: justify;"> |
886 |
|
|
|
887 |
|
|
<i>Swine:</i> |
888 |
|
|
|
889 |
|
|
</p> |
890 |
|
|
</div> |
891 |
|
|
|
892 |
|
|
|
893 |
|
|
|
894 |
|
|
|
895 |
|
|
|
896 |
|
|
|
897 |
|
|
|
898 |
|
|
|
899 |
|
|
|
900 |
|
|
|
901 |
|
|
|
902 |
|
|
|
903 |
|
|
<div align="justify"> |
904 |
|
|
<p style="text-align: justify;"> |
905 |
|
|
|
906 |
|
|
0.5% in feed (0.5 kg of Trimetosul<b><sup>®</sup></b> P homogeneously mixed with 100 kg of feed). |
907 |
|
|
|
908 |
|
|
</p> |
909 |
|
|
</div> |
910 |
|
|
|
911 |
|
|
|
912 |
|
|
|
913 |
|
|
|
914 |
|
|
|
915 |
|
|
|
916 |
|
|
|
917 |
|
|
|
918 |
|
|
|
919 |
|
|
|
920 |
|
|
|
921 |
|
|
|
922 |
|
|
<div align="justify"> |
923 |
|
|
<p style="text-align: justify;"> |
924 |
|
|
|
925 |
|
|
|
926 |
|
|
|
927 |
|
|
</p> |
928 |
|
|
</div> |
929 |
|
|
|
930 |
|
|
|
931 |
|
|
|
932 |
|
|
|
933 |
|
|
|
934 |
|
|
|
935 |
|
|
|
936 |
|
|
|
937 |
|
|
|
938 |
|
|
|
939 |
|
|
|
940 |
|
|
|
941 |
|
|
<div align="justify"> |
942 |
|
|
<p style="text-align: justify;"> |
943 |
|
|
|
944 |
|
|
<i>Calves:</i> |
945 |
|
|
|
946 |
|
|
</p> |
947 |
|
|
</div> |
948 |
|
|
|
949 |
|
|
|
950 |
|
|
|
951 |
|
|
|
952 |
|
|
|
953 |
|
|
|
954 |
|
|
|
955 |
|
|
|
956 |
|
|
|
957 |
|
|
|
958 |
|
|
|
959 |
|
|
|
960 |
|
|
<div align="justify"> |
961 |
|
|
<p style="text-align: justify;"> |
962 |
|
|
|
963 |
|
|
1.5% in feed (1.5 kg of Trimetosul<b><sup>®</sup></b> P homogeneously mixed with 100 kg of feed). |
964 |
|
|
|
965 |
|
|
</p> |
966 |
|
|
</div> |
967 |
|
|
|
968 |
|
|
|
969 |
|
|
|
970 |
|
|
|
971 |
|
|
|
972 |
|
|
|
973 |
|
|
|
974 |
|
|
|
975 |
|
|
|
976 |
|
|
|
977 |
|
|
|
978 |
|
|
|
979 |
|
|
<div align="justify"> |
980 |
|
|
<p style="text-align: justify;"> |
981 |
|
|
|
982 |
|
|
|
983 |
|
|
|
984 |
|
|
</p> |
985 |
|
|
</div> |
986 |
|
|
|
987 |
|
|
|
988 |
|
|
|
989 |
|
|
|
990 |
|
|
|
991 |
|
|
|
992 |
|
|
|
993 |
|
|
|
994 |
|
|
|
995 |
|
|
|
996 |
|
|
|
997 |
|
|
|
998 |
|
|
<div align="justify"> |
999 |
|
|
<p style="text-align: justify;"> |
1000 |
|
|
|
1001 |
|
|
<i>Poultry:</i> |
1002 |
|
|
|
1003 |
|
|
</p> |
1004 |
|
|
</div> |
1005 |
|
|
|
1006 |
|
|
|
1007 |
|
|
|
1008 |
|
|
|
1009 |
|
|
|
1010 |
|
|
|
1011 |
|
|
|
1012 |
|
|
|
1013 |
|
|
|
1014 |
|
|
|
1015 |
|
|
|
1016 |
|
|
|
1017 |
|
|
<div align="justify"> |
1018 |
|
|
<p style="text-align: justify;"> |
1019 |
|
|
|
1020 |
|
|
0.2% in feed (0.2 kg of Trimetosul<b><sup>®</sup></b> P homogeneously mixed with 100 kg of feed). |
1021 |
|
|
|
1022 |
|
|
</p> |
1023 |
|
|
</div> |
1024 |
|
|
|
1025 |
|
|
|
1026 |
|
|
|
1027 |
|
|
|
1028 |
|
|
|
1029 |
|
|
|
1030 |
|
|
|
1031 |
|
|
|
1032 |
|
|
|
1033 |
|
|
|
1034 |
|
|
|
1035 |
|
|
|
1036 |
|
|
<div align="justify"> |
1037 |
|
|
<p style="text-align: justify;"> |
1038 |
|
|
|
1039 |
|
|
|
1040 |
|
|
|
1041 |
|
|
</p> |
1042 |
|
|
</div> |
1043 |
|
|
|
1044 |
|
|
|
1045 |
|
|
|
1046 |
|
|
|
1047 |
|
|
|
1048 |
|
|
|
1049 |
|
|
|
1050 |
|
|
|
1051 |
|
|
|
1052 |
|
|
|
1053 |
|
|
|
1054 |
|
|
|
1055 |
|
|
<div align="justify"> |
1056 |
|
|
<p style="text-align: justify;"> |
1057 |
|
|
|
1058 |
|
|
<b><i>Side effects</i></b> |
1059 |
|
|
|
1060 |
|
|
</p> |
1061 |
|
|
</div> |
1062 |
|
|
|
1063 |
|
|
|
1064 |
|
|
|
1065 |
|
|
|
1066 |
|
|
|
1067 |
|
|
|
1068 |
|
|
|
1069 |
|
|
|
1070 |
|
|
|
1071 |
|
|
|
1072 |
|
|
|
1073 |
|
|
|
1074 |
|
|
<div align="justify"> |
1075 |
|
|
<p style="text-align: justify;"> |
1076 |
|
|
|
1077 |
|
|
Unknown. |
1078 |
|
|
|
1079 |
|
|
</p> |
1080 |
|
|
</div> |
1081 |
|
|
|
1082 |
|
|
|
1083 |
|
|
|
1084 |
|
|
|
1085 |
|
|
|
1086 |
|
|
|
1087 |
|
|
|
1088 |
|
|
|
1089 |
|
|
|
1090 |
|
|
|
1091 |
|
|
|
1092 |
|
|
|
1093 |
|
|
<div align="justify"> |
1094 |
|
|
<p style="text-align: justify;"> |
1095 |
|
|
|
1096 |
|
|
|
1097 |
|
|
|
1098 |
|
|
</p> |
1099 |
|
|
</div> |
1100 |
|
|
|
1101 |
|
|
|
1102 |
|
|
|
1103 |
|
|
|
1104 |
|
|
|
1105 |
|
|
|
1106 |
|
|
|
1107 |
|
|
|
1108 |
|
|
|
1109 |
|
|
|
1110 |
|
|
|
1111 |
|
|
|
1112 |
|
|
<div align="justify"> |
1113 |
|
|
<p style="text-align: justify;"> |
1114 |
|
|
|
1115 |
|
|
<b><i>Warnings and precautions</i></b><b></b> |
1116 |
|
|
|
1117 |
|
|
</p> |
1118 |
|
|
</div> |
1119 |
|
|
|
1120 |
|
|
|
1121 |
|
|
|
1122 |
|
|
|
1123 |
|
|
|
1124 |
|
|
|
1125 |
|
|
|
1126 |
|
|
|
1127 |
|
|
|
1128 |
|
|
|
1129 |
|
|
|
1130 |
|
|
|
1131 |
|
|
<div align="justify"> |
1132 |
|
|
<p style="text-align: justify;"> |
1133 |
|
|
|
1134 |
|
|
Sick animals taking scarce feed should be treated parenterally (e. g. Trimetosul<b><sup>®</sup></b> 48% injection suspension). |
1135 |
|
|
|
1136 |
|
|
</p> |
1137 |
|
|
</div> |
1138 |
|
|
|
1139 |
|
|
|
1140 |
|
|
|
1141 |
|
|
|
1142 |
|
|
|
1143 |
|
|
|
1144 |
|
|
|
1145 |
|
|
|
1146 |
|
|
|
1147 |
|
|
|
1148 |
|
|
|
1149 |
|
|
|
1150 |
|
|
<div align="justify"> |
1151 |
|
|
<p style="text-align: justify;"> |
1152 |
|
|
|
1153 |
|
|
|
1154 |
|
|
|
1155 |
|
|
</p> |
1156 |
|
|
</div> |
1157 |
|
|
|
1158 |
|
|
|
1159 |
|
|
|
1160 |
|
|
|
1161 |
|
|
|
1162 |
|
|
|
1163 |
|
|
|
1164 |
|
|
|
1165 |
|
|
|
1166 |
|
|
|
1167 |
|
|
|
1168 |
|
|
|
1169 |
|
|
<div align="justify"> |
1170 |
|
|
<p style="text-align: justify;"> |
1171 |
|
|
|
1172 |
|
|
During treatment with medicated ration, the animals should not have access to any other source of feed. |
1173 |
|
|
|
1174 |
|
|
</p> |
1175 |
|
|
</div> |
1176 |
|
|
|
1177 |
|
|
|
1178 |
|
|
|
1179 |
|
|
|
1180 |
|
|
|
1181 |
|
|
|
1182 |
|
|
|
1183 |
|
|
|
1184 |
|
|
|
1185 |
|
|
|
1186 |
|
|
|
1187 |
|
|
|
1188 |
|
|
<div align="justify"> |
1189 |
|
|
<p style="text-align: justify;"> |
1190 |
|
|
|
1191 |
|
|
|
1192 |
|
|
|
1193 |
|
|
</p> |
1194 |
|
|
</div> |
1195 |
|
|
|
1196 |
|
|
|
1197 |
|
|
|
1198 |
|
|
|
1199 |
|
|
|
1200 |
|
|
|
1201 |
|
|
|
1202 |
|
|
|
1203 |
|
|
|
1204 |
|
|
|
1205 |
|
|
|
1206 |
|
|
|
1207 |
|
|
<div align="justify"> |
1208 |
|
|
<p style="text-align: justify;"> |
1209 |
|
|
|
1210 |
|
|
To minimise renal impairment during the treatment, the animals should have free access to drinking water. |
1211 |
|
|
|
1212 |
|
|
</p> |
1213 |
|
|
</div> |
1214 |
|
|
|
1215 |
|
|
|
1216 |
|
|
|
1217 |
|
|
|
1218 |
|
|
|
1219 |
|
|
|
1220 |
|
|
|
1221 |
|
|
|
1222 |
|
|
|
1223 |
|
|
|
1224 |
|
|
|
1225 |
|
|
|
1226 |
|
|
<div align="justify"> |
1227 |
|
|
<p style="text-align: justify;"> |
1228 |
|
|
|
1229 |
|
|
|
1230 |
|
|
|
1231 |
|
|
</p> |
1232 |
|
|
</div> |
1233 |
|
|
|
1234 |
|
|
|
1235 |
|
|
|
1236 |
|
|
|
1237 |
|
|
|
1238 |
|
|
|
1239 |
|
|
|
1240 |
|
|
|
1241 |
|
|
|
1242 |
|
|
|
1243 |
|
|
|
1244 |
|
|
|
1245 |
|
|
<div align="justify"> |
1246 |
|
|
<p style="text-align: justify;"> |
1247 |
|
|
|
1248 |
|
|
Prolonged administration of high doses of sulfonamide may interfere with disintegration of cellulose in the forestomach of ruminants. |
1249 |
|
|
|
1250 |
|
|
</p> |
1251 |
|
|
</div> |
1252 |
|
|
|
1253 |
|
|
|
1254 |
|
|
|
1255 |
|
|
|
1256 |
|
|
|
1257 |
|
|
|
1258 |
|
|
|
1259 |
|
|
|
1260 |
|
|
|
1261 |
|
|
|
1262 |
|
|
|
1263 |
|
|
|
1264 |
|
|
<div align="justify"> |
1265 |
|
|
<p style="text-align: justify;"> |
1266 |
|
|
|
1267 |
|
|
|
1268 |
|
|
|
1269 |
|
|
</p> |
1270 |
|
|
</div> |
1271 |
|
|
|
1272 |
|
|
|
1273 |
|
|
|
1274 |
|
|
|
1275 |
|
|
|
1276 |
|
|
|
1277 |
|
|
|
1278 |
|
|
|
1279 |
|
|
|
1280 |
|
|
|
1281 |
|
|
|
1282 |
|
|
|
1283 |
|
|
<div align="justify"> |
1284 |
|
|
<p style="text-align: justify;"> |
1285 |
|
|
|
1286 |
|
|
Sulfonamides rarely decrease broilers' leaving capacity or gain. |
1287 |
|
|
|
1288 |
|
|
</p> |
1289 |
|
|
</div> |
1290 |
|
|
|
1291 |
|
|
|
1292 |
|
|
|
1293 |
|
|
|
1294 |
|
|
|
1295 |
|
|
|
1296 |
|
|
|
1297 |
|
|
|
1298 |
|
|
|
1299 |
|
|
|
1300 |
|
|
|
1301 |
|
|
|
1302 |
|
|
<div align="justify"> |
1303 |
|
|
<p style="text-align: justify;"> |
1304 |
|
|
|
1305 |
|
|
|
1306 |
|
|
|
1307 |
|
|
</p> |
1308 |
|
|
</div> |
1309 |
|
|
|
1310 |
|
|
|
1311 |
|
|
|
1312 |
|
|
|
1313 |
|
|
|
1314 |
|
|
|
1315 |
|
|
|
1316 |
|
|
|
1317 |
|
|
|
1318 |
|
|
|
1319 |
|
|
|
1320 |
|
|
|
1321 |
|
|
<div align="justify"> |
1322 |
|
|
<p style="text-align: justify;"> |
1323 |
|
|
|
1324 |
|
|
To prevent potential incompatibility, Trimetosul<b><sup>®</sup></b> P should not be mixed with other drugs or medicated additives. |
1325 |
|
|
|
1326 |
|
|
</p> |
1327 |
|
|
</div> |
1328 |
|
|
|
1329 |
|
|
|
1330 |
|
|
|
1331 |
|
|
|
1332 |
|
|
|
1333 |
|
|
|
1334 |
|
|
|
1335 |
|
|
|
1336 |
|
|
|
1337 |
|
|
|
1338 |
|
|
|
1339 |
|
|
|
1340 |
|
|
<div align="justify"> |
1341 |
|
|
<p style="text-align: justify;"> |
1342 |
|
|
|
1343 |
|
|
|
1344 |
|
|
|
1345 |
|
|
</p> |
1346 |
|
|
</div> |
1347 |
|
|
|
1348 |
|
|
|
1349 |
|
|
|
1350 |
|
|
|
1351 |
|
|
|
1352 |
|
|
|
1353 |
|
|
|
1354 |
|
|
|
1355 |
|
|
|
1356 |
|
|
|
1357 |
|
|
|
1358 |
|
|
|
1359 |
|
|
<div align="justify"> |
1360 |
|
|
<p style="text-align: justify;"> |
1361 |
|
|
|
1362 |
|
|
As with other antimicrobials, when using wear face/eyes protection, suitable protective clothing and shoes. Avoid contact with skin and mucosa. After handling thoroughly wash with water and soap. |
1363 |
|
|
|
1364 |
|
|
</p> |
1365 |
|
|
</div> |
1366 |
|
|
|
1367 |
|
|
|
1368 |
|
|
|
1369 |
|
|
|
1370 |
|
|
|
1371 |
|
|
|
1372 |
|
|
|
1373 |
|
|
|
1374 |
|
|
|
1375 |
|
|
|
1376 |
|
|
|
1377 |
|
|
|
1378 |
|
|
<div align="justify"> |
1379 |
|
|
<p style="text-align: justify;"> |
1380 |
|
|
|
1381 |
|
|
|
1382 |
|
|
|
1383 |
|
|
</p> |
1384 |
|
|
</div> |
1385 |
|
|
|
1386 |
|
|
|
1387 |
|
|
|
1388 |
|
|
|
1389 |
|
|
|
1390 |
|
|
|
1391 |
|
|
|
1392 |
|
|
|
1393 |
|
|
|
1394 |
|
|
|
1395 |
|
|
|
1396 |
|
|
|
1397 |
|
|
<div align="justify"> |
1398 |
|
|
<p style="text-align: justify;"> |
1399 |
|
|
|
1400 |
|
|
<b><i>Withdrawal</i></b><b></b> |
1401 |
|
|
|
1402 |
|
|
</p> |
1403 |
|
|
</div> |
1404 |
|
|
|
1405 |
|
|
|
1406 |
|
|
|
1407 |
|
|
|
1408 |
|
|
|
1409 |
|
|
|
1410 |
|
|
|
1411 |
|
|
|
1412 |
|
|
|
1413 |
|
|
|
1414 |
|
|
|
1415 |
|
|
|
1416 |
|
|
<div align="justify"> |
1417 |
|
|
<p style="text-align: justify;"> |
1418 |
|
|
|
1419 |
|
|
Meat and other edible tissues - |
1420 |
|
|
|
1421 |
|
|
</p> |
1422 |
|
|
</div> |
1423 |
|
|
|
1424 |
|
|
|
1425 |
|
|
|
1426 |
|
|
|
1427 |
|
|
|
1428 |
|
|
|
1429 |
|
|
|
1430 |
|
|
|
1431 |
|
|
|
1432 |
|
|
|
1433 |
|
|
|
1434 |
|
|
|
1435 |
|
|
<div align="justify"> |
1436 |
|
|
<p style="text-align: justify;"> |
1437 |
|
|
|
1438 |
|
|
calves, swine 8 days |
1439 |
|
|
|
1440 |
|
|
</p> |
1441 |
|
|
</div> |
1442 |
|
|
|
1443 |
|
|
|
1444 |
|
|
|
1445 |
|
|
|
1446 |
|
|
|
1447 |
|
|
|
1448 |
|
|
|
1449 |
|
|
|
1450 |
|
|
|
1451 |
|
|
|
1452 |
|
|
|
1453 |
|
|
|
1454 |
|
|
<div align="justify"> |
1455 |
|
|
<p style="text-align: justify;"> |
1456 |
|
|
|
1457 |
|
|
poultry 4 days |
1458 |
|
|
|
1459 |
|
|
</p> |
1460 |
|
|
</div> |
1461 |
|
|
|
1462 |
|
|
|
1463 |
|
|
|
1464 |
|
|
|
1465 |
|
|
|
1466 |
|
|
|
1467 |
|
|
|
1468 |
|
|
|
1469 |
|
|
|
1470 |
|
|
|
1471 |
|
|
|
1472 |
|
|
|
1473 |
|
|
<div align="justify"> |
1474 |
|
|
<p style="text-align: justify;"> |
1475 |
|
|
|
1476 |
|
|
Eggs 10 days |
1477 |
|
|
|
1478 |
|
|
</p> |
1479 |
|
|
</div> |
1480 |
|
|
|
1481 |
|
|
|
1482 |
|
|
|
1483 |
|
|
|
1484 |
|
|
|
1485 |
|
|
|
1486 |
|
|
|
1487 |
|
|
|
1488 |
|
|
|
1489 |
|
|
|
1490 |
|
|
|
1491 |
|
|
|
1492 |
|
|
<div align="justify"> |
1493 |
|
|
<p style="text-align: justify;"> |
1494 |
|
|
|
1495 |
|
|
|
1496 |
|
|
|
1497 |
|
|
</p> |
1498 |
|
|
</div> |
1499 |
|
|
|
1500 |
|
|
|
1501 |
|
|
|
1502 |
|
|
|
1503 |
|
|
|
1504 |
|
|
|
1505 |
|
|
|
1506 |
|
|
|
1507 |
|
|
|
1508 |
|
|
|
1509 |
|
|
|
1510 |
|
|
|
1511 |
|
|
<div align="justify"> |
1512 |
|
|
<p style="text-align: justify;"> |
1513 |
|
|
|
1514 |
|
|
<b><i>Storage</i></b><b></b> |
1515 |
|
|
|
1516 |
|
|
</p> |
1517 |
|
|
</div> |
1518 |
|
|
|
1519 |
|
|
|
1520 |
|
|
|
1521 |
|
|
|
1522 |
|
|
|
1523 |
|
|
|
1524 |
|
|
|
1525 |
|
|
|
1526 |
|
|
|
1527 |
|
|
|
1528 |
|
|
|
1529 |
|
|
|
1530 |
|
|
<div align="justify"> |
1531 |
|
|
<p style="text-align: justify;"> |
1532 |
|
|
|
1533 |
|
|
Store in a dry and dark place at room temperature (up to 25°C). Keep away from children. |
1534 |
|
|
|
1535 |
|
|
</p> |
1536 |
|
|
</div> |
1537 |
|
|
|
1538 |
|
|
|
1539 |
|
|
|
1540 |
|
|
|
1541 |
|
|
|
1542 |
|
|
|
1543 |
|
|
|
1544 |
|
|
|
1545 |
|
|
|
1546 |
|
|
|
1547 |
|
|
|
1548 |
|
|
|
1549 |
|
|
<div align="justify"> |
1550 |
|
|
<p style="text-align: justify;"> |
1551 |
|
|
|
1552 |
|
|
|
1553 |
|
|
|
1554 |
|
|
</p> |
1555 |
|
|
</div> |
1556 |
|
|
|
1557 |
|
|
|
1558 |
|
|
|
1559 |
|
|
|
1560 |
|
|
|
1561 |
|
|
|
1562 |
|
|
|
1563 |
|
|
|
1564 |
|
|
|
1565 |
|
|
|
1566 |
|
|
|
1567 |
|
|
|
1568 |
|
|
<div align="justify"> |
1569 |
|
|
<p style="text-align: justify;"> |
1570 |
|
|
|
1571 |
|
|
<b><i>Shelf life</i></b><b></b> |
1572 |
|
|
|
1573 |
|
|
</p> |
1574 |
|
|
</div> |
1575 |
|
|
|
1576 |
|
|
|
1577 |
|
|
|
1578 |
|
|
|
1579 |
|
|
|
1580 |
|
|
|
1581 |
|
|
|
1582 |
|
|
|
1583 |
|
|
|
1584 |
|
|
|
1585 |
|
|
|
1586 |
|
|
|
1587 |
|
|
<div align="justify"> |
1588 |
|
|
<p style="text-align: justify;"> |
1589 |
|
|
|
1590 |
|
|
Denoted on the packaging (18 months in the original pack). |
1591 |
|
|
|
1592 |
|
|
</p> |
1593 |
|
|
</div> |
1594 |
|
|
|
1595 |
|
|
|
1596 |
|
|
|
1597 |
|
|
|
1598 |
|
|
|
1599 |
|
|
|
1600 |
|
|
|
1601 |
|
|
|
1602 |
|
|
|
1603 |
|
|
|
1604 |
|
|
|
1605 |
|
|
|
1606 |
|
|
<div align="justify"> |
1607 |
|
|
<p style="text-align: justify;"> |
1608 |
|
|
|
1609 |
|
|
|
1610 |
|
|
|
1611 |
|
|
</p> |
1612 |
|
|
</div> |
1613 |
|
|
|
1614 |
|
|
|
1615 |
|
|
|
1616 |
|
|
|
1617 |
|
|
|
1618 |
|
|
|
1619 |
|
|
|
1620 |
|
|
|
1621 |
|
|
|
1622 |
|
|
|
1623 |
|
|
|
1624 |
|
|
|
1625 |
|
|
<div align="justify"> |
1626 |
|
|
<p style="text-align: justify;"> |
1627 |
|
|
|
1628 |
|
|
Once prepared use within 3 months. |
1629 |
|
|
|
1630 |
|
|
</p> |
1631 |
|
|
</div> |
1632 |
|
|
|
1633 |
|
|
|
1634 |
|
|
|
1635 |
|
|
|
1636 |
|
|
|
1637 |
|
|
|
1638 |
|
|
|
1639 |
|
|
|
1640 |
|
|
|
1641 |
|
|
|
1642 |
|
|
|
1643 |
|
|
|
1644 |
|
|
<div align="justify"> |
1645 |
|
|
<p style="text-align: justify;"> |
1646 |
|
|
|
1647 |
|
|
|
1648 |
|
|
|
1649 |
|
|
</p> |
1650 |
|
|
</div> |
1651 |
|
|
|
1652 |
|
|
|
1653 |
|
|
|
1654 |
|
|
|
1655 |
|
|
|
1656 |
|
|
|
1657 |
|
|
|
1658 |
|
|
|
1659 |
|
|
|
1660 |
|
|
|
1661 |
|
|
|
1662 |
|
|
|
1663 |
|
|
<div align="justify"> |
1664 |
|
|
<p style="text-align: justify;"> |
1665 |
|
|
|
1666 |
|
|
<b><i>Legal category</i></b><b></b> |
1667 |
|
|
|
1668 |
|
|
</p> |
1669 |
|
|
</div> |
1670 |
|
|
|
1671 |
|
|
|
1672 |
|
|
|
1673 |
|
|
|
1674 |
|
|
|
1675 |
|
|
|
1676 |
|
|
|
1677 |
|
|
|
1678 |
|
|
|
1679 |
|
|
|
1680 |
|
|
|
1681 |
|
|
|
1682 |
|
|
<div align="justify"> |
1683 |
|
|
<p style="text-align: justify;"> |
1684 |
|
|
|
1685 |
|
|
On prescription only. |
1686 |
|
|
|
1687 |
|
|
</p> |
1688 |
|
|
</div> |
1689 |
|
|
|
1690 |
|
|
|
1691 |
|
|
|
1692 |
|
|
|
1693 |
|
|
|
1694 |
|
|
|
1695 |
|
|
|
1696 |
|
|
|
1697 |
|
|
|
1698 |
|
|
|
1699 |
|
|
|
1700 |
|
|
|
1701 |
|
|
<div align="justify"> |
1702 |
|
|
<p style="text-align: justify;"> |
1703 |
|
|
|
1704 |
|
|
|
1705 |
|
|
|
1706 |
|
|
</p> |
1707 |
|
|
</div> |
1708 |
|
|
|
1709 |
|
|
|
1710 |
|
|
|
1711 |
|
|
|
1712 |
|
|
|
1713 |
|
|
|
1714 |
|
|
|
1715 |
|
|
|
1716 |
|
|
|
1717 |
|
|
|
1718 |
|
|
|
1719 |
|
|
|
1720 |
|
|
<div align="justify"> |
1721 |
|
|
<p style="text-align: justify;"> |
1722 |
|
|
|
1723 |
|
|
<b><i>Supply</i></b><b> </b> |
1724 |
|
|
|
1725 |
|
|
</p> |
1726 |
|
|
</div> |
1727 |
|
|
|
1728 |
|
|
|
1729 |
|
|
|
1730 |
|
|
|
1731 |
|
|
|
1732 |
|
|
|
1733 |
|
|
|
1734 |
|
|
|
1735 |
|
|
|
1736 |
|
|
|
1737 |
|
|
|
1738 |
|
|
|
1739 |
|
|
<div align="justify"> |
1740 |
|
|
<p style="text-align: justify;"> |
1741 |
|
|
|
1742 |
|
|
Bag with 25 kg. |
1743 |
|
|
|
1744 |
|
|
</p> |
1745 |
|
|
</div> |
1746 |
|
|
|
1747 |
|
|
|
1748 |
|
|
|
1749 |
|
|
|
1750 |
|
|
|
1751 |
|
|
|
1752 |
|
|
|
1753 |
|
|
|
1754 |
|
|
|
1755 |
|
|
|
1756 |
|
|
|
1757 |
|
|
|
1758 |
|
|
<div align="justify"> |
1759 |
|
|
<p style="text-align: justify;"> |
1760 |
|
|
|
1761 |
|
|
|
1762 |
|
|
|
1763 |
|
|
</p> |
1764 |
|
|
</div> |
1765 |
|
|
|
1766 |
|
|
|
1767 |
|
|
|
1768 |
|
|
|
1769 |
|
|
|
1770 |
|
|
|
1771 |
|
|
|
1772 |
|
|
|
1773 |
|
|
|
1774 |
|
|
|
1775 |
|
|
|
1776 |
|
|
|
1777 |
|
|
<div align="justify"> |
1778 |
|
|
<p style="text-align: justify;"> |
1779 |
|
|
|
1780 |
|
|
<b><i>Manufacturer</i></b><b></b> |
1781 |
|
|
|
1782 |
|
|
</p> |
1783 |
|
|
</div> |
1784 |
|
|
|
1785 |
|
|
|
1786 |
|
|
|
1787 |
|
|
|
1788 |
|
|
|
1789 |
|
|
|
1790 |
|
|
|
1791 |
|
|
|
1792 |
|
|
|
1793 |
|
|
|
1794 |
|
|
|
1795 |
|
|
|
1796 |
|
|
<div align="justify"> |
1797 |
|
|
<p style="text-align: justify;"> |
1798 |
|
|
|
1799 |
|
|
VETERINA Animal Health Ltd., Croatia |
1800 |
|
|
|
1801 |
|
|
</p> |
1802 |
|
|
</div> |
1803 |
|
|
|
1804 |
|
|
|
1805 |
|
|
|
1806 |
|
|
|
1807 |
|
|
|
1808 |
|
|
|
1809 |
|
|
|
1810 |
|
|
|
1811 |
|
|
|
1812 |
|
|
|
1813 |
|
|
|
1814 |
|
|
|
1815 |
|
|
<div align="justify"> |
1816 |
|
|
<p style="text-align: justify;"> |
1817 |
|
|
|
1818 |
|
|
|
1819 |
|
|
|
1820 |
|
|
</p> |
1821 |
|
|
</div> |
1822 |
|
|
|
1823 |
|
|
|
1824 |
|
|
|
1825 |
|
|
|
1826 |
|
|
|
1827 |
|
|
|
1828 |
|
|
|
1829 |
|
|
|
1830 |
|
|
|
1831 |
|
|
|
1832 |
|
|
|
1833 |
|
|
|
1834 |
|
|
<div align="left"> |
1835 |
|
|
<p style="text-align: left;"> |
1836 |
|
|
|
1837 |
|
|
|
1838 |
|
|
|
1839 |
|
|
</p> |
1840 |
|
|
</div> |
1841 |
|
|
|
1842 |
|
|
|
1843 |
|
|
|
1844 |
|
|
|
1845 |
|
|
|
1846 |
|
|
|
1847 |
|
|
|
1848 |
|
|
<!--Section Ends--> |
1849 |
|
|
|
1850 |
|
|
|
1851 |
|
|
|
1852 |
|
|
|
1853 |
|
|
|
1854 |
|
|
|
1855 |
|
|
|
1856 |
|
|
|