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Revision 1.2 - (show annotations)
Tue Apr 10 11:02:11 2001 UTC (18 years, 4 months ago) by dpavlin
Branch: MAIN
CVS Tags: HEAD
Changes since 1.1: +4 -4 lines
File MIME type: text/html
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1
2
3 <!--Section Begins--><br>
4
5
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7
8
9
10 <div align="justify">
11 <p style="text-align: justify;">
12
13
14
15 </p>
16 </div>
17
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24
25
26
27
28
29 <div align="justify">
30 <p style="text-align: justify;">
31
32 <b>PLIVACILLIN</b><b><sup>®</sup></b>
33
34 </p>
35 </div>
36
37
38
39
40
41
42
43
44
45
46
47
48 <div align="justify">
49 <p style="text-align: justify;">
50
51 <i>dry injections </i>- powder for injection suspension/solution
52
53 </p>
54 </div>
55
56
57
58
59
60
61
62
63
64
65
66
67 <div align="justify">
68 <p style="text-align: justify;">
69
70
71
72 </p>
73 </div>
74
75
76
77
78
79
80
81
82
83
84
85
86 <div align="justify">
87 <p style="text-align: justify;">
88
89 <b><i>Composition</i></b>
90
91 </p>
92 </div>
93
94
95
96
97
98
99
100
101
102
103
104
105 <div align="justify">
106 <p style="text-align: justify;">
107
108 Each bottle contains:
109
110 </p>
111 </div>
112
113
114
115
116
117
118
119
120
121
122
123
124 <div align="justify">
125 <p style="text-align: justify;">
126
127 100,000, 200,000 or 1,000,000 iu of benzylpenicillin potassium and
128
129 </p>
130 </div>
131
132
133
134
135
136
137
138
139
140
141
142
143 <div align="justify">
144 <p style="text-align: justify;">
145
146 300,000, 600,000 or 3,000,000 iu of benzylpenicillin procaine
147
148 </p>
149 </div>
150
151
152
153
154
155
156
157
158
159
160
161
162 <div align="justify">
163 <p style="text-align: justify;">
164
165
166
167 </p>
168 </div>
169
170
171
172
173
174
175
176
177
178
179
180
181 <div align="justify">
182 <p style="text-align: justify;">
183
184 <b><i>Action</i></b><b></b>
185
186 </p>
187 </div>
188
189
190
191
192
193
194
195
196
197
198
199
200 <div align="justify">
201 <p style="text-align: justify;">
202
203 Plivacillin<b><sup>®</sup></b> is a mixture of readily soluble crystalline benzylpenicillin potassium, which acts immediately after administration, and of sparingly soluble benzylpenicillin procaine, which has a prolonged action due to its slow resorption. The preparation is used for the treatment and prophylaxis of the infections caused by gram-positive organisms: streptococci, enterococci, pneumococci, Corynebacteria, actinomycetes, leptospira, anthrax and swine erysipelas bacteria, etc.
204
205 </p>
206 </div>
207
208
209
210
211
212
213
214
215
216
217
218
219 <div align="justify">
220 <p style="text-align: justify;">
221
222
223
224 </p>
225 </div>
226
227
228
229
230
231
232
233
234
235
236
237
238 <div align="justify">
239 <p style="text-align: justify;">
240
241 <b><i>Indications</i></b><b></b>
242
243 </p>
244 </div>
245
246
247
248
249
250
251
252
253
254
255
256
257 <div align="justify">
258 <p style="text-align: justify;">
259
260 Some major indications:
261
262 </p>
263 </div>
264
265
266
267
268
269
270
271
272
273
274 <ul>
275 <li>
276
277 <div align="justify">
278 <p style="text-align: justify;">
279
280 streptococcal, stastaphylococcal and enterococcal infections;
281
282 </p>
283 </div>
284
285
286
287
288
289
290
291
292
293
294 <li>
295
296 <div align="justify">
297 <p style="text-align: justify;">
298
299 specific infections: swine erysipelas, leptospirosis, tetanus, actinomycosis, etc.;
300
301 </p>
302 </div>
303
304
305
306
307
308
309
310
311
312
313 <li>
314
315 <div align="justify">
316 <p style="text-align: justify;">
317
318 secondary bacterial infections associated with and following viral diseases (distemper, panleukopenia, parvovirosis, viral bronchopneumonia, equine influenza, etc.);
319
320 </p>
321 </div>
322
323
324
325
326
327
328
329
330
331
332 <li>
333
334 <div align="justify">
335 <p style="text-align: justify;">
336
337 puerperal infections, metritis, mastitis (accompanied by local treatment), MMA syndrome in sows;
338
339 </p>
340 </div>
341
342
343
344
345
346
347
348
349
350
351 <li>
352
353 <div align="justify">
354 <p style="text-align: justify;">
355
356 phlegmonas, pyodermia, abscesses, infected wounds, panaritium, acute suppurative arthritis, umbilical infections, etc.
357
358 </p>
359 </div>
360
361
362
363
364
365
366
367
368
369
370 </ul>
371
372 <div align="justify">
373 <p style="text-align: justify;">
374
375
376
377 </p>
378 </div>
379
380
381
382
383
384
385
386
387
388
389
390
391 <div align="justify">
392 <p style="text-align: justify;">
393
394 <b><i>Contraindications</i></b>
395
396 </p>
397 </div>
398
399
400
401
402
403
404
405
406
407
408
409
410 <div align="justify">
411 <p style="text-align: justify;">
412
413 Plivacillin<b><sup>®</sup></b> should not be administered by i. v. route.
414
415 </p>
416 </div>
417
418
419
420
421
422
423
424
425
426
427
428
429 <div align="justify">
430 <p style="text-align: justify;">
431
432
433
434 </p>
435 </div>
436
437
438
439
440
441
442
443
444
445
446
447
448 <div align="justify">
449 <p style="text-align: justify;">
450
451 Established hypersensitivity to beta-lactam antibiotics or the ingredients of Plivacillin<b><sup>®</sup></b>.
452
453 </p>
454 </div>
455
456
457
458
459
460
461
462
463
464
465
466
467 <div align="justify">
468 <p style="text-align: justify;">
469
470
471
472 </p>
473 </div>
474
475
476
477
478
479
480
481
482
483
484
485
486 <div align="justify">
487 <p style="text-align: justify;">
488
489 Penicillins should not be given to rabbits, guinea-pigs, hamsters and other small monogastric herbivore.
490
491 </p>
492 </div>
493
494
495
496
497
498
499
500
501
502
503
504
505 <div align="justify">
506 <p style="text-align: justify;">
507
508
509
510 </p>
511 </div>
512
513
514
515
516
517
518
519
520
521
522
523
524 <div align="justify">
525 <p style="text-align: justify;">
526
527 <b><i>Administration and dosage</i></b><b></b>
528
529 </p>
530 </div>
531
532
533
534
535
536
537
538
539
540
541
542
543 <div align="justify">
544 <p style="text-align: justify;">
545
546 Immediately prior to administration resuspend the contents of the bottle in as small amount of water for injection as possible (400,000 iu/2 mL; 800,000 iu/4-5 mL; 4,000,000 iu/10 mL). Before injecting the obtained solution-suspension into the syringe and prior to its administration, shake it several times. In general, the injections are not painful because smaller portion of the preparation is dissolved and major is re-suspended.
547
548 </p>
549 </div>
550
551
552
553
554
555
556
557
558
559
560
561
562 <div align="justify">
563 <p style="text-align: justify;">
564
565
566
567 </p>
568 </div>
569
570
571
572
573
574
575
576
577 <table width="87.71%" border="1" cols="2" rows="3">
578 <tr>
579 <td bgcolor="White" width="20.59%" rowspan="1" colspan="1">
580
581 <div align="justify">
582 <p style="text-align: justify;">
583
584 Species
585
586 </p>
587 </div>
588
589
590
591
592 </td>
593
594
595
596
597
598 <td bgcolor="White" width="79.41%" rowspan="1" colspan="1">
599
600 <div align="justify">
601 <p style="text-align: justify;">
602
603 Dose
604
605 </p>
606 </div>
607
608
609
610
611 </td>
612
613
614
615
616
617
618
619 </tr>
620
621
622
623 <tr>
624 <td bgcolor="White" width="20.59%" rowspan="1" colspan="1">
625
626 <div align="justify">
627 <p style="text-align: justify;">
628
629 Dogs, cats
630
631 </p>
632 </div>
633
634
635
636
637 </td>
638
639
640
641
642
643 <td bgcolor="White" width="79.41%" rowspan="1" colspan="1">
644
645 <div align="justify">
646 <p style="text-align: justify;">
647
648 20 000 iu/kg b. w. (e. g. 400 000 iu /20 kg b. w.)
649
650 </p>
651 </div>
652
653
654
655
656
657
658
659
660
661
662
663
664 <div align="justify">
665 <p style="text-align: justify;">
666
667
668
669 </p>
670 </div>
671
672
673
674
675 </td>
676
677
678
679
680
681
682
683 </tr>
684
685
686
687 <tr>
688 <td bgcolor="White" width="20.59%" rowspan="1" colspan="1">
689
690 <div align="justify">
691 <p style="text-align: justify;">
692
693 Horses, cattle,
694
695 </p>
696 </div>
697
698
699
700
701
702
703
704
705
706
707
708
709 <div align="justify">
710 <p style="text-align: justify;">
711
712 swine, sheep
713
714 </p>
715 </div>
716
717
718
719
720 </td>
721
722
723
724
725
726 <td bgcolor="White" width="79.41%" rowspan="1" colspan="1">
727
728 <div align="justify">
729 <p style="text-align: justify;">
730
731 10 000 - 15 000 iu/kg b. w. (e. g. 800 000 iu /55-80 kg b. w.;
732
733 </p>
734 </div>
735
736
737
738
739
740
741
742
743
744
745
746
747 <div align="justify">
748 <p style="text-align: justify;">
749
750 4 000 000 iu/270-400 kg).
751
752 </p>
753 </div>
754
755
756
757
758 </td>
759
760
761
762
763
764
765
766 </tr>
767
768 </table>
769
770
771
772
773 <div align="justify">
774 <p style="text-align: justify;">
775
776
777
778 </p>
779 </div>
780
781
782
783
784
785
786
787
788
789
790
791
792 <div align="justify">
793 <p style="text-align: justify;">
794
795 Large animals are given Plivacillin<b><sup>®</sup></b> by deep i.m. injection, dogs and cats by s.c. or i.m. route. In the treatment of local infections Plivacillin<b><sup>®</sup></b> is injected into the surrounding tissue or directly into the process. Before injecting check if the needle is erroneously in the blood vessel.
796
797 </p>
798 </div>
799
800
801
802
803
804
805
806
807
808
809
810
811 <div align="justify">
812 <p style="text-align: justify;">
813
814
815
816 </p>
817 </div>
818
819
820
821
822
823
824
825
826
827
828
829
830 <div align="justify">
831 <p style="text-align: justify;">
832
833 Plivacillin<b><sup>®</sup></b> is given once daily plus at least two more days after remission of fever and clinical signs. In severe infections the dose may be increased.
834
835 </p>
836 </div>
837
838
839
840
841
842
843
844
845
846
847
848
849 <div align="justify">
850 <p style="text-align: justify;">
851
852
853
854 </p>
855 </div>
856
857
858
859
860
861
862
863
864
865
866
867
868 <div align="justify">
869 <p style="text-align: justify;">
870
871 To broaden antimicrobial spectrum, Plivacillin<b><sup>®</sup></b> may be given concomitantly with dihydrostreptomycin (e. g. Hystrecin<b><sup>®</sup></b> (PLIVA).
872
873 </p>
874 </div>
875
876
877
878
879
880
881
882
883
884
885
886
887 <div align="justify">
888 <p style="text-align: justify;">
889
890
891
892 </p>
893 </div>
894
895
896
897
898
899
900
901
902
903
904
905
906 <div align="justify">
907 <p style="text-align: justify;">
908
909 <b><i>Warnings and precautions</i></b>
910
911 </p>
912 </div>
913
914
915
916
917
918
919
920
921
922
923
924
925 <div align="justify">
926 <p style="text-align: justify;">
927
928 Once resuspended, i. e. dissolved, use immediately.
929
930 </p>
931 </div>
932
933
934
935
936
937
938
939
940
941
942
943
944 <div align="justify">
945 <p style="text-align: justify;">
946
947
948
949 </p>
950 </div>
951
952
953
954
955
956
957
958
959
960
961
962
963 <div align="justify">
964 <p style="text-align: justify;">
965
966 Plivacillin<b><sup>®</sup></b> should not be injected on two consecutive days at the same site.
967
968 </p>
969 </div>
970
971
972
973
974
975
976
977
978
979
980
981
982 <div align="justify">
983 <p style="text-align: justify;">
984
985
986
987 </p>
988 </div>
989
990
991
992
993
994
995
996
997
998
999
1000
1001 <div align="justify">
1002 <p style="text-align: justify;">
1003
1004 Preparations containing procaine penicillin may very seldom cause fever and induce abortion in the swine infected by erysipelas (<i>Erysipelothrix insidiosa</i>).
1005
1006 </p>
1007 </div>
1008
1009
1010
1011
1012
1013
1014
1015
1016
1017
1018
1019
1020 <div align="justify">
1021 <p style="text-align: justify;">
1022
1023
1024
1025 </p>
1026 </div>
1027
1028
1029
1030
1031
1032
1033
1034
1035
1036
1037
1038
1039 <div align="justify">
1040 <p style="text-align: justify;">
1041
1042 In case of allergic reactions, which are rare in animals, discontinue Plivacillin<b><sup>®</sup></b> and institute adrenaline, glucocorticoids and antihistaminics.
1043
1044 </p>
1045 </div>
1046
1047
1048
1049
1050
1051
1052
1053
1054
1055
1056
1057
1058 <div align="justify">
1059 <p style="text-align: justify;">
1060
1061
1062
1063 </p>
1064 </div>
1065
1066
1067
1068
1069
1070
1071
1072
1073
1074
1075
1076
1077 <div align="justify">
1078 <p style="text-align: justify;">
1079
1080 <b><i>Withdrawal</i></b><b></b>
1081
1082 </p>
1083 </div>
1084
1085
1086
1087
1088
1089
1090
1091
1092
1093
1094
1095
1096 <div align="justify">
1097 <p style="text-align: justify;">
1098
1099 Meat and other edible tissues of cattle, swine, sheep, goats 10 days.
1100
1101 </p>
1102 </div>
1103
1104
1105
1106
1107
1108
1109
1110
1111
1112
1113
1114
1115 <div align="justify">
1116 <p style="text-align: justify;">
1117
1118 Cows' milk 3 days
1119
1120 </p>
1121 </div>
1122
1123
1124
1125
1126
1127
1128
1129
1130
1131
1132
1133
1134 <div align="justify">
1135 <p style="text-align: justify;">
1136
1137
1138
1139 </p>
1140 </div>
1141
1142
1143
1144
1145
1146
1147
1148
1149
1150
1151
1152
1153 <div align="justify">
1154 <p style="text-align: justify;">
1155
1156 <b><i>Storage</i></b><b></b>
1157
1158 </p>
1159 </div>
1160
1161
1162
1163
1164
1165
1166
1167
1168
1169
1170
1171
1172 <div align="justify">
1173 <p style="text-align: justify;">
1174
1175 Store in a dark place at controlled room temperature (15-25°C). Keep away from children.
1176
1177 </p>
1178 </div>
1179
1180
1181
1182
1183
1184
1185
1186
1187
1188
1189
1190
1191 <div align="justify">
1192 <p style="text-align: justify;">
1193
1194
1195
1196 </p>
1197 </div>
1198
1199
1200
1201
1202
1203
1204
1205
1206
1207
1208
1209
1210 <div align="justify">
1211 <p style="text-align: justify;">
1212
1213 <b><i>Shelf life</i></b>
1214
1215 </p>
1216 </div>
1217
1218
1219
1220
1221
1222
1223
1224
1225
1226
1227
1228
1229 <div align="justify">
1230 <p style="text-align: justify;">
1231
1232 Denoted on the packaging (4 years in the original pack).
1233
1234 </p>
1235 </div>
1236
1237
1238
1239
1240
1241
1242
1243
1244
1245
1246
1247
1248 <div align="justify">
1249 <p style="text-align: justify;">
1250
1251
1252
1253 </p>
1254 </div>
1255
1256
1257
1258
1259
1260
1261
1262
1263
1264
1265
1266
1267 <div align="justify">
1268 <p style="text-align: justify;">
1269
1270 <b><i>Legal category</i></b><b></b>
1271
1272 </p>
1273 </div>
1274
1275
1276
1277
1278
1279
1280
1281
1282
1283
1284
1285
1286 <div align="justify">
1287 <p style="text-align: justify;">
1288
1289 On prescription only.
1290
1291 </p>
1292 </div>
1293
1294
1295
1296
1297
1298
1299
1300
1301
1302
1303
1304
1305 <div align="justify">
1306 <p style="text-align: justify;">
1307
1308
1309
1310 </p>
1311 </div>
1312
1313
1314
1315
1316
1317
1318
1319
1320
1321
1322
1323
1324 <div align="justify">
1325 <p style="text-align: justify;">
1326
1327 Supply<b></b>
1328
1329 </p>
1330 </div>
1331
1332
1333
1334
1335
1336
1337
1338
1339
1340
1341
1342
1343 <div align="justify">
1344 <p style="text-align: justify;">
1345
1346 50 liobottles with 400,000 iu (100,000 iu + 300,000 iu)
1347
1348 </p>
1349 </div>
1350
1351
1352
1353
1354
1355
1356
1357
1358
1359
1360
1361
1362 <div align="justify">
1363 <p style="text-align: justify;">
1364
1365 50 liobottles with 800,000 iu (200,000 iu + 600,000 iu)
1366
1367 </p>
1368 </div>
1369
1370
1371
1372
1373
1374
1375
1376
1377
1378
1379
1380
1381 <div align="justify">
1382 <p style="text-align: justify;">
1383
1384 1 liobottle with 4,000,000 iu (1,000,000 iu + 3,000,000 iu).
1385
1386 </p>
1387 </div>
1388
1389
1390
1391
1392
1393
1394
1395
1396
1397
1398
1399
1400 <div align="justify">
1401 <p style="text-align: justify;">
1402
1403
1404
1405 </p>
1406 </div>
1407
1408
1409
1410
1411
1412
1413
1414
1415
1416
1417
1418
1419 <div align="justify">
1420 <p style="text-align: justify;">
1421
1422 <b><i>Manufacturer</i></b><b></b>
1423
1424 </p>
1425 </div>
1426
1427
1428
1429
1430
1431
1432
1433
1434
1435
1436
1437
1438 <div align="justify">
1439 <p style="text-align: justify;">
1440
1441 VETERINA Animal Health Ltd., Croatia
1442
1443 </p>
1444 </div>
1445
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