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<!--Section Begins--><br> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b>HIBISTREP</b><b><sup>®</sup></b> |
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</p> |
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</div> |
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<p style="text-align: justify;"> |
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<i>soluble powder</i> |
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</p> |
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</div> |
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<div align="justify"> |
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<b></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Composition</i></b> |
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</p> |
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</div> |
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1 g contains 250 mg of streptomycin sulphate and 35 mg of chlorhexidine hydrochloride. |
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</p> |
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</div> |
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<div align="justify"> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Action</i></b> |
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</p> |
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A combination of the active ingredients ensures synergistic action based on structural changes in the cell membrane lipids caused by chlorhexidine. This facilitates bacterial penetration of the antibiotic and enhances its activity there. In sensitive bacteria streptomycin inhibits protein synthesis, while its therapeutic doses act bactericidally. Antimicrobial activity covers mostly gram-negative and many gram-positive and acidoresistant organisms (<i>Actinomyces</i> spp., <i>E</i>. <i>coli</i>, <i>Pasteurella</i> spp., <i>Salmonella</i> spp., <i>Campylobacter</i> spp. and <i>Actinobacillus</i> spp.). |
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</p> |
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</div> |
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</div> |
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<p style="text-align: justify;"> |
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Chlorhexidine has a broad spectrum of activity against gram-positive and gram-negative bacteria as well as against fungi and algae. Orally administered streptomycin is vary hardly resorbed (only 2 -4% of it), and because it is resistant to gastric hydrochloric acid it achieves high intestinal levels. Poor solubility of chlorhexidine hydrochloride contributes to the prolonged antibacterial activity, which makes the preparation very suitable in the control of intestinal infections. |
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</p> |
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<div align="justify"> |
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</div> |
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<p style="text-align: justify;"> |
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<b><i>Indications</i></b><b></b> |
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</p> |
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</div> |
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Treatment and control of: |
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</div> |
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<p style="text-align: justify;"> |
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- gastrointestinal bacterial infections in domestic animals (colibacillosis, salmonellosis, pasteurellosis); |
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</div> |
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<p style="text-align: justify;"> |
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- non-specific enteritis in chicks and turkeys; |
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</p> |
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</div> |
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<p style="text-align: justify;"> |
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- ulcerative enteritis in chicks, turkeys and quails; |
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</p> |
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</div> |
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- early deaths in fowl; |
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</div> |
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- diarrhoea in the weaned piglets. |
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</p> |
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</div> |
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Boosting of productivity in animals (improving weight gain and feed conversion). |
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</p> |
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</div> |
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</p> |
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</div> |
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<b><i>Contraindications</i></b> |
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</p> |
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</div> |
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Unknown. |
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</p> |
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</div> |
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</p> |
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</div> |
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<b><i>Administration and dosage</i></b><b></b> |
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</p> |
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</div> |
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<b><i>Suckling piglets</i></b><i>: </i>1 g of powder/kg of b. w. daily dissolved in water or milk. |
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</p> |
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</div> |
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</p> |
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</div> |
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<p style="text-align: justify;"> |
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<i>Swine:</i> 1 g of powder per 1 L of drinking water or 0.3% with feed (mix homogeneously 0.3 kg of Hibistrep<b><sup>®</sup></b> powder with 100 kg of feed). |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<i>Poultry:</i> 2 g of powder in 1 L of drinking water. Increase the dose to 6 g/1 L of water when treating ulcerative enteritis. If administered with feed, the dose is 0.6% (mix homogeneously 0.6 kg of Hibistrep<b><sup>®</sup></b> powder with 100 kg of feed). Apply twice, e. g. from days 1-7 and 30-40 of the fattening period. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<i>Calves, foals:</i><b><i> </i></b>4-8 g of powder daily dissolved in drinking water, milk or milk substitute and divided in two subdoses. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<i>Lambs: </i>2-4 g of powder daily dissolved in drinking water or milk and divided in two subdoses. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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In case of individual treatment, the powder is administered in 12-24 hour intervals and usually given over 3-5 days. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Warnings and precautions</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Always prepare a fresh solution. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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To ensure the intake of the medicated drinking water, the animals should be restricted from other sources of liquid during the treatment. |
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</p> |
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</div> |
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| 786 |
|
| 787 |
|
| 788 |
|
| 789 |
<div align="justify"> |
| 790 |
<p style="text-align: justify;"> |
| 791 |
|
| 792 |
|
| 793 |
|
| 794 |
</p> |
| 795 |
</div> |
| 796 |
|
| 797 |
|
| 798 |
|
| 799 |
|
| 800 |
|
| 801 |
|
| 802 |
|
| 803 |
|
| 804 |
|
| 805 |
|
| 806 |
|
| 807 |
|
| 808 |
<div align="justify"> |
| 809 |
<p style="text-align: justify;"> |
| 810 |
|
| 811 |
Once prepared use within 24 hours. |
| 812 |
|
| 813 |
</p> |
| 814 |
</div> |
| 815 |
|
| 816 |
|
| 817 |
|
| 818 |
|
| 819 |
|
| 820 |
|
| 821 |
|
| 822 |
|
| 823 |
|
| 824 |
|
| 825 |
|
| 826 |
|
| 827 |
<div align="justify"> |
| 828 |
<p style="text-align: justify;"> |
| 829 |
|
| 830 |
|
| 831 |
|
| 832 |
</p> |
| 833 |
</div> |
| 834 |
|
| 835 |
|
| 836 |
|
| 837 |
|
| 838 |
|
| 839 |
|
| 840 |
|
| 841 |
|
| 842 |
|
| 843 |
|
| 844 |
|
| 845 |
|
| 846 |
<div align="justify"> |
| 847 |
<p style="text-align: justify;"> |
| 848 |
|
| 849 |
<b><i>Withdrawal</i></b><b></b> |
| 850 |
|
| 851 |
</p> |
| 852 |
</div> |
| 853 |
|
| 854 |
|
| 855 |
|
| 856 |
|
| 857 |
|
| 858 |
|
| 859 |
|
| 860 |
|
| 861 |
|
| 862 |
|
| 863 |
|
| 864 |
|
| 865 |
<div align="justify"> |
| 866 |
<p style="text-align: justify;"> |
| 867 |
|
| 868 |
Meat, organs and other edible tissues |
| 869 |
|
| 870 |
</p> |
| 871 |
</div> |
| 872 |
|
| 873 |
|
| 874 |
|
| 875 |
|
| 876 |
|
| 877 |
|
| 878 |
|
| 879 |
|
| 880 |
|
| 881 |
|
| 882 |
|
| 883 |
|
| 884 |
<div align="justify"> |
| 885 |
<p style="text-align: justify;"> |
| 886 |
|
| 887 |
broilers and turkeys 4 days |
| 888 |
|
| 889 |
</p> |
| 890 |
</div> |
| 891 |
|
| 892 |
|
| 893 |
|
| 894 |
|
| 895 |
|
| 896 |
|
| 897 |
|
| 898 |
|
| 899 |
|
| 900 |
|
| 901 |
|
| 902 |
|
| 903 |
<div align="justify"> |
| 904 |
<p style="text-align: justify;"> |
| 905 |
|
| 906 |
Swine, cattle, sheep 10 days |
| 907 |
|
| 908 |
</p> |
| 909 |
</div> |
| 910 |
|
| 911 |
|
| 912 |
|
| 913 |
|
| 914 |
|
| 915 |
|
| 916 |
|
| 917 |
|
| 918 |
|
| 919 |
|
| 920 |
|
| 921 |
|
| 922 |
<div align="justify"> |
| 923 |
<p style="text-align: justify;"> |
| 924 |
|
| 925 |
Eggs 0 days |
| 926 |
|
| 927 |
</p> |
| 928 |
</div> |
| 929 |
|
| 930 |
|
| 931 |
|
| 932 |
|
| 933 |
|
| 934 |
|
| 935 |
|
| 936 |
|
| 937 |
|
| 938 |
|
| 939 |
|
| 940 |
|
| 941 |
<div align="justify"> |
| 942 |
<p style="text-align: justify;"> |
| 943 |
|
| 944 |
|
| 945 |
|
| 946 |
</p> |
| 947 |
</div> |
| 948 |
|
| 949 |
|
| 950 |
|
| 951 |
|
| 952 |
|
| 953 |
|
| 954 |
|
| 955 |
|
| 956 |
|
| 957 |
|
| 958 |
|
| 959 |
|
| 960 |
<div align="justify"> |
| 961 |
<p style="text-align: justify;"> |
| 962 |
|
| 963 |
<b><i>Storage</i></b><b></b> |
| 964 |
|
| 965 |
</p> |
| 966 |
</div> |
| 967 |
|
| 968 |
|
| 969 |
|
| 970 |
|
| 971 |
|
| 972 |
|
| 973 |
|
| 974 |
|
| 975 |
|
| 976 |
|
| 977 |
|
| 978 |
|
| 979 |
<div align="justify"> |
| 980 |
<p style="text-align: justify;"> |
| 981 |
|
| 982 |
Store in a dark and dry place at room temperature (up to 25°C). Keep away from children. |
| 983 |
|
| 984 |
</p> |
| 985 |
</div> |
| 986 |
|
| 987 |
|
| 988 |
|
| 989 |
|
| 990 |
|
| 991 |
|
| 992 |
|
| 993 |
|
| 994 |
|
| 995 |
|
| 996 |
|
| 997 |
|
| 998 |
<div align="justify"> |
| 999 |
<p style="text-align: justify;"> |
| 1000 |
|
| 1001 |
|
| 1002 |
|
| 1003 |
</p> |
| 1004 |
</div> |
| 1005 |
|
| 1006 |
|
| 1007 |
|
| 1008 |
|
| 1009 |
|
| 1010 |
|
| 1011 |
|
| 1012 |
|
| 1013 |
|
| 1014 |
|
| 1015 |
|
| 1016 |
|
| 1017 |
<div align="justify"> |
| 1018 |
<p style="text-align: justify;"> |
| 1019 |
|
| 1020 |
<b><i>Legal category</i></b> |
| 1021 |
|
| 1022 |
</p> |
| 1023 |
</div> |
| 1024 |
|
| 1025 |
|
| 1026 |
|
| 1027 |
|
| 1028 |
|
| 1029 |
|
| 1030 |
|
| 1031 |
|
| 1032 |
|
| 1033 |
|
| 1034 |
|
| 1035 |
|
| 1036 |
<div align="justify"> |
| 1037 |
<p style="text-align: justify;"> |
| 1038 |
|
| 1039 |
On prescription only. |
| 1040 |
|
| 1041 |
</p> |
| 1042 |
</div> |
| 1043 |
|
| 1044 |
|
| 1045 |
|
| 1046 |
|
| 1047 |
|
| 1048 |
|
| 1049 |
|
| 1050 |
|
| 1051 |
|
| 1052 |
|
| 1053 |
|
| 1054 |
|
| 1055 |
<div align="justify"> |
| 1056 |
<p style="text-align: justify;"> |
| 1057 |
|
| 1058 |
|
| 1059 |
|
| 1060 |
</p> |
| 1061 |
</div> |
| 1062 |
|
| 1063 |
|
| 1064 |
|
| 1065 |
|
| 1066 |
|
| 1067 |
|
| 1068 |
|
| 1069 |
|
| 1070 |
|
| 1071 |
|
| 1072 |
|
| 1073 |
|
| 1074 |
<div align="justify"> |
| 1075 |
<p style="text-align: justify;"> |
| 1076 |
|
| 1077 |
<b><i>Shelf life</i></b><b></b> |
| 1078 |
|
| 1079 |
</p> |
| 1080 |
</div> |
| 1081 |
|
| 1082 |
|
| 1083 |
|
| 1084 |
|
| 1085 |
|
| 1086 |
|
| 1087 |
|
| 1088 |
|
| 1089 |
|
| 1090 |
|
| 1091 |
|
| 1092 |
|
| 1093 |
<div align="justify"> |
| 1094 |
<p style="text-align: justify;"> |
| 1095 |
|
| 1096 |
Denoted on the packaging (3 years in the original pack). |
| 1097 |
|
| 1098 |
</p> |
| 1099 |
</div> |
| 1100 |
|
| 1101 |
|
| 1102 |
|
| 1103 |
|
| 1104 |
|
| 1105 |
|
| 1106 |
|
| 1107 |
|
| 1108 |
|
| 1109 |
|
| 1110 |
|
| 1111 |
|
| 1112 |
<div align="justify"> |
| 1113 |
<p style="text-align: justify;"> |
| 1114 |
|
| 1115 |
<b></b> |
| 1116 |
|
| 1117 |
</p> |
| 1118 |
</div> |
| 1119 |
|
| 1120 |
|
| 1121 |
|
| 1122 |
|
| 1123 |
|
| 1124 |
|
| 1125 |
|
| 1126 |
|
| 1127 |
|
| 1128 |
|
| 1129 |
|
| 1130 |
|
| 1131 |
<div align="justify"> |
| 1132 |
<p style="text-align: justify;"> |
| 1133 |
|
| 1134 |
<b><i>Supply</i></b><b></b> |
| 1135 |
|
| 1136 |
</p> |
| 1137 |
</div> |
| 1138 |
|
| 1139 |
|
| 1140 |
|
| 1141 |
|
| 1142 |
|
| 1143 |
|
| 1144 |
|
| 1145 |
|
| 1146 |
|
| 1147 |
|
| 1148 |
|
| 1149 |
|
| 1150 |
<div align="justify"> |
| 1151 |
<p style="text-align: justify;"> |
| 1152 |
|
| 1153 |
Boxes with bags of 10 x 20 g and bag with 1000 g. |
| 1154 |
|
| 1155 |
</p> |
| 1156 |
</div> |
| 1157 |
|
| 1158 |
|
| 1159 |
|
| 1160 |
|
| 1161 |
|
| 1162 |
|
| 1163 |
|
| 1164 |
|
| 1165 |
|
| 1166 |
|
| 1167 |
|
| 1168 |
|
| 1169 |
<div align="justify"> |
| 1170 |
<p style="text-align: justify;"> |
| 1171 |
|
| 1172 |
|
| 1173 |
|
| 1174 |
</p> |
| 1175 |
</div> |
| 1176 |
|
| 1177 |
|
| 1178 |
|
| 1179 |
|
| 1180 |
|
| 1181 |
|
| 1182 |
|
| 1183 |
|
| 1184 |
|
| 1185 |
|
| 1186 |
|
| 1187 |
|
| 1188 |
<div align="justify"> |
| 1189 |
<p style="text-align: justify;"> |
| 1190 |
|
| 1191 |
<b><i>Manufacturer</i></b><b></b> |
| 1192 |
|
| 1193 |
</p> |
| 1194 |
</div> |
| 1195 |
|
| 1196 |
|
| 1197 |
|
| 1198 |
|
| 1199 |
|
| 1200 |
|
| 1201 |
|
| 1202 |
|
| 1203 |
|
| 1204 |
|
| 1205 |
|
| 1206 |
|
| 1207 |
<div align="justify"> |
| 1208 |
<p style="text-align: justify;"> |
| 1209 |
|
| 1210 |
VETERINA Animal Health Ltd., Croatia |
| 1211 |
|
| 1212 |
</p> |
| 1213 |
</div> |
| 1214 |
|
| 1215 |
|
| 1216 |
|
| 1217 |
|
| 1218 |
|
| 1219 |
|
| 1220 |
|
| 1221 |
|
| 1222 |
|
| 1223 |
|
| 1224 |
|
| 1225 |
|
| 1226 |
<div align="justify"> |
| 1227 |
<p style="text-align: justify;"> |
| 1228 |
|
| 1229 |
|
| 1230 |
|
| 1231 |
</p> |
| 1232 |
</div> |
| 1233 |
|
| 1234 |
|
| 1235 |
|
| 1236 |
|
| 1237 |
|
| 1238 |
|
| 1239 |
|
| 1240 |
|
| 1241 |
|
| 1242 |
|
| 1243 |
|
| 1244 |
|
| 1245 |
<div align="left"> |
| 1246 |
<p style="text-align: left;"> |
| 1247 |
|
| 1248 |
|
| 1249 |
|
| 1250 |
</p> |
| 1251 |
</div> |
| 1252 |
|
| 1253 |
|
| 1254 |
|
| 1255 |
|
| 1256 |
|
| 1257 |
|
| 1258 |
|
| 1259 |
<!--Section Ends--> |
| 1260 |
|
| 1261 |
|
| 1262 |
|
| 1263 |
|
| 1264 |
|
| 1265 |
|
| 1266 |
|
| 1267 |
|
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