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Revision 1.2 - (show annotations)
Tue Apr 10 11:02:10 2001 UTC (18 years ago) by dpavlin
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1
2
3 <!--Section Begins--><br>
4
5
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9
10 <div align="justify">
11 <p style="text-align: justify;">
12
13
14
15 </p>
16 </div>
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24
25
26
27
28
29 <div align="justify">
30 <p style="text-align: justify;">
31
32 <b>GEOMYCIN</b><b><sup>® </sup></b><b> 20%</b>
33
34 </p>
35 </div>
36
37
38
39
40
41
42
43
44
45
46
47
48 <div align="justify">
49 <p style="text-align: justify;">
50
51 <i>soluble powder</i>
52
53 </p>
54 </div>
55
56
57
58
59
60
61
62
63
64
65
66
67 <div align="justify">
68 <p style="text-align: justify;">
69
70 <b></b>
71
72 </p>
73 </div>
74
75
76
77
78
79
80
81
82
83
84
85
86 <div align="justify">
87 <p style="text-align: justify;">
88
89 <b><i>Composition</i></b>
90
91 </p>
92 </div>
93
94
95
96
97
98
99
100
101
102
103
104
105 <div align="justify">
106 <p style="text-align: justify;">
107
108 1 g contains 200 mg of oxytetracycline hydrochloride and up to 1 g of corrigens and carrier.
109
110 </p>
111 </div>
112
113
114
115
116
117
118
119
120
121
122
123
124 <div align="justify">
125 <p style="text-align: justify;">
126
127
128
129 </p>
130 </div>
131
132
133
134
135
136
137
138
139
140
141
142
143 <div align="justify">
144 <p style="text-align: justify;">
145
146 <b><i>Action</i></b><b></b>
147
148 </p>
149 </div>
150
151
152
153
154
155
156
157
158
159
160
161
162 <div align="justify">
163 <p style="text-align: justify;">
164
165 Oxytetracycline is a bacteriostatic broad-spectrum antimicrobial antibiotic. It is effective against many gram-positive organisms, such as streptococci and staphylococci, and it inhibits the growth and multiplication of mycoplasmas, spirochetes, chlamydiae and rickettsiae. Geomycin<b><sup>® </sup></b>is active against the following gram-positive organisms: <i>Actinomyces</i> spp., <i>Clostridium</i> <i>perfringens</i>, <i>Cl.</i> <i>tetani</i>, <i>Listeria</i> <i>monocytogenes </i>and <i>Nocardia</i> spp. and the following gram-negative pathogens: <i>Bordetella</i> spp., <i>Brucella</i> spp.,<i> Bartonella</i> spp., <i>Haemophilus</i> spp., <i>Pasteurella</i> <i>multocida</i>, <i>Shigella</i> spp. and <i>Yersinia</i> <i>pestis</i>. Majority of enterobacteriae (<i>E.</i> <i>coli</i>, <i>Enterobacter</i> spp., <i>Klebsiella</i> spp., <i>Proteus</i> and<i> Serratia</i> spp., <i>Bacteroides</i> and <i>Pseudomonas</i> <i>aeuroginosa) </i>are often<i> </i>resistant to<i> </i>oxytetracycline. When given by mouth Geomycin<b><sup>®</sup></b> 20% soluble powder is dissolved in drinking water or mixed in feed. Taken so it is rapidly resorbed and in large amounts found in blood and most tissues.
166
167 </p>
168 </div>
169
170
171
172
173
174
175
176
177
178
179
180
181 <div align="justify">
182 <p style="text-align: justify;">
183
184
185
186 </p>
187 </div>
188
189
190
191
192
193
194
195
196
197
198
199
200 <div align="justify">
201 <p style="text-align: justify;">
202
203 <b><i>Indications</i></b>
204
205 </p>
206 </div>
207
208
209
210
211
212
213
214
215
216
217
218
219 <div align="justify">
220 <p style="text-align: justify;">
221
222 Primary and secondary bacterial infections of gastrointestinal, respiratory and genitourinary tracts, septicaemia caused by oxytetracycline-sensitive bacteria in poultry, small and large ruminants, swine, dogs, cats, rabbits and fish. Some major indications for Geomycin<b><sup>®</sup></b> 20 % soluble powder are:
223
224 </p>
225 </div>
226
227
228
229
230
231
232
233
234
235
236
237
238 <div align="justify">
239 <p style="text-align: justify;">
240
241
242
243 </p>
244 </div>
245
246
247
248
249
250
251
252
253
254
255
256
257 <div align="justify">
258 <p style="text-align: justify;">
259
260 <i>Cattle</i>
261
262 </p>
263 </div>
264
265
266
267
268
269
270
271
272
273
274
275
276 <div align="justify">
277 <p style="text-align: justify;">
278
279 Calves: bacterial enteritis;
280
281 </p>
282 </div>
283
284
285
286
287
288
289
290
291
292
293
294
295 <div align="justify">
296 <p style="text-align: justify;">
297
298 Heifers: prophylaxis of respiratory infections, e. g. enzootic bronchopneumonia complex.
299
300 </p>
301 </div>
302
303
304
305
306
307
308
309
310
311
312
313
314 <div align="justify">
315 <p style="text-align: justify;">
316
317
318
319 </p>
320 </div>
321
322
323
324
325
326
327
328
329
330
331
332
333 <div align="justify">
334 <p style="text-align: justify;">
335
336 <i>Swine</i>
337
338 </p>
339 </div>
340
341
342
343
344
345
346
347
348
349
350
351
352 <div align="justify">
353 <p style="text-align: justify;">
354
355 Respiratory infections - e. g. enzootic bronchopneumonia, atrophic rhinitis, leptospirosis, eperythrozoonosis etc.
356
357 </p>
358 </div>
359
360
361
362
363
364
365
366
367
368
369
370
371 <div align="justify">
372 <p style="text-align: justify;">
373
374
375
376 </p>
377 </div>
378
379
380
381
382
383
384
385
386
387
388
389
390 <div align="justify">
391 <p style="text-align: justify;">
392
393 <i>Broilers and turkeys</i>
394
395 </p>
396 </div>
397
398
399
400
401
402
403
404
405
406
407
408
409 <div align="justify">
410 <p style="text-align: justify;">
411
412 Respiratory infections caused by <i>E.</i> <i>coli</i>, <i>Pasteurella</i> spp. and <i>Erysipelothrix</i> <i>insidiosa</i> - only in turkeys.
413
414 </p>
415 </div>
416
417
418
419
420
421
422
423
424
425
426
427
428 <div align="justify">
429 <p style="text-align: justify;">
430
431
432
433 </p>
434 </div>
435
436
437
438
439
440
441
442
443
444
445
446
447 <div align="justify">
448 <p style="text-align: justify;">
449
450 <i>Fish</i>
451
452 </p>
453 </div>
454
455
456
457
458
459
460
461
462
463
464
465
466 <div align="justify">
467 <p style="text-align: justify;">
468
469 Trouts: furunculosis;
470
471 </p>
472 </div>
473
474
475
476
477
478
479
480
481
482
483
484
485 <div align="justify">
486 <p style="text-align: justify;">
487
488 Carps: erythrodermatitis and inflammation of the swimming bladder.
489
490 </p>
491 </div>
492
493
494
495
496
497
498
499
500
501
502
503
504 <div align="justify">
505 <p style="text-align: justify;">
506
507 <b></b>
508
509 </p>
510 </div>
511
512
513
514
515
516
517
518
519
520
521
522
523 <div align="justify">
524 <p style="text-align: justify;">
525
526 <b><i>Contraindications</i></b><b></b>
527
528 </p>
529 </div>
530
531
532
533
534
535
536
537
538
539
540
541
542 <div align="justify">
543 <p style="text-align: justify;">
544
545 Therapy with Geomycin<b><sup>®</sup></b> 20% soluble powder instituted to the fattening heifers and other adult ruminants should not be longer than 5 days, to avoid its adverse effect on microflora of forestomach.
546
547 </p>
548 </div>
549
550
551
552
553
554
555
556
557
558
559
560
561 <div align="justify">
562 <p style="text-align: justify;">
563
564
565
566 </p>
567 </div>
568
569
570
571
572
573
574
575
576
577
578
579
580 <div align="justify">
581 <p style="text-align: justify;">
582
583 The drug should not be given in severe hepatic and/or renal impairment.
584
585 </p>
586 </div>
587
588
589
590
591
592
593
594
595
596
597
598
599 <div align="justify">
600 <p style="text-align: justify;">
601
602
603
604 </p>
605 </div>
606
607
608
609
610
611
612
613
614
615
616
617
618 <div align="justify">
619 <p style="text-align: justify;">
620
621 Due to inhibition of the immune response, fish should not be concomitantly immunised and treated with oxytetracycline.
622
623 </p>
624 </div>
625
626
627
628
629
630
631
632
633
634
635
636
637 <div align="justify">
638 <p style="text-align: justify;">
639
640
641
642 </p>
643 </div>
644
645
646
647
648
649
650
651
652
653
654
655
656 <div align="justify">
657 <p style="text-align: justify;">
658
659 <b><i>Administration</i></b>
660
661 </p>
662 </div>
663
664
665
666
667
668
669
670
671
672
673
674
675 <div align="justify">
676 <p style="text-align: justify;">
677
678 The powder is given dissolved in drinking water or mixed with feed. When given in drinking water always prepare a fresh solution.
679
680 </p>
681 </div>
682
683
684
685
686
687
688
689
690
691
692
693
694 <div align="justify">
695 <p style="text-align: justify;">
696
697
698
699 </p>
700 </div>
701
702
703
704
705
706
707
708
709
710
711
712
713 <div align="justify">
714 <p style="text-align: justify;">
715
716 For fish, Geomycin<b><sup>®</sup></b> 20% soluble powder is most frequently mixed with the pelleted feed. First spray edible oil over the pellets in the amount of 1L of oil/25 kg of pellets. Dredge corresponding amount of Geomycin<b><sup>®</sup></b> 20% soluble powder over the feed, mix well and allow to dry till use. Daily ration for fish is 1-2% of their body weight, given with the morning meal. Usual duration of treatment is 10 consecutive days.
717
718 </p>
719 </div>
720
721
722
723
724
725
726
727
728
729
730
731
732 <div align="justify">
733 <p style="text-align: justify;">
734
735
736
737 </p>
738 </div>
739
740
741
742
743
744
745
746
747
748
749
750
751 <div align="justify">
752 <p style="text-align: justify;">
753
754 <b><i>Dosage</i></b>
755
756 </p>
757 </div>
758
759
760
761
762
763
764
765
766
767
768
769
770 <div align="justify">
771 <p style="text-align: justify;">
772
773 <i>Poultry</i>
774
775 </p>
776 </div>
777
778
779
780
781
782
783
784
785
786
787
788
789 <div align="justify">
790 <p style="text-align: justify;">
791
792 In drinking water: 40-160 g of powder per 100 L of water (80-320 mg/L).
793
794 </p>
795 </div>
796
797
798
799
800
801
802
803
804
805
806
807
808 <div align="justify">
809 <p style="text-align: justify;">
810
811
812
813 </p>
814 </div>
815
816
817
818
819
820
821
822
823
824
825
826
827 <div align="justify">
828 <p style="text-align: justify;">
829
830 In feed: 500-2500 g of powder per 1 ton of feed (100-500 ppm); usual duration of treatment is 4-5 days.
831
832 </p>
833 </div>
834
835
836
837
838
839
840
841
842
843
844
845
846 <div align="justify">
847 <p style="text-align: justify;">
848
849
850
851 </p>
852 </div>
853
854
855
856
857
858
859
860
861
862
863
864
865 <div align="justify">
866 <p style="text-align: justify;">
867
868 <i>Calves, foals, lambs, kids, swine and rabbits</i>
869
870 </p>
871 </div>
872
873
874
875
876
877
878
879
880
881
882
883
884 <div align="justify">
885 <p style="text-align: justify;">
886
887 0.5-1.0 g of powder/10 kg of b. w. (10-20 mg of oxytetracycline/kg of b.w.) over 4-5 days;
888
889 </p>
890 </div>
891
892
893
894
895
896
897
898
899
900
901
902
903 <div align="justify">
904 <p style="text-align: justify;">
905
906
907
908 </p>
909 </div>
910
911
912
913
914
915
916
917
918
919
920
921
922 <div align="justify">
923 <p style="text-align: justify;">
924
925 Treatment of leptospirosis in swine: 1 kg of preparation mixed in 1 ton of feed (200 ppm) given over 7-14 days.
926
927 </p>
928 </div>
929
930
931
932
933
934
935
936
937
938
939
940
941 <div align="justify">
942 <p style="text-align: justify;">
943
944
945
946 </p>
947 </div>
948
949
950
951
952
953
954
955
956
957
958
959
960 <div align="justify">
961 <p style="text-align: justify;">
962
963 <i>Fish</i>
964
965 </p>
966 </div>
967
968
969
970
971
972
973
974
975
976
977
978
979 <div align="justify">
980 <p style="text-align: justify;">
981
982 Treatment of furunculosis and erythrodermatitis: 3 g of powder per 10 kg of b. w. (60 mg/kg of b. w.).
983
984 </p>
985 </div>
986
987
988
989
990
991
992
993
994
995
996
997
998 <div align="justify">
999 <p style="text-align: justify;">
1000
1001
1002
1003 </p>
1004 </div>
1005
1006
1007
1008
1009
1010
1011
1012
1013
1014
1015
1016
1017 <div align="justify">
1018 <p style="text-align: justify;">
1019
1020 Control of mortality in case of skin impairment; inflammation of the swimming bladder; control of <i>Haemophilus piscium</i> infection: 4 g of powder per 10 kg of b. w. (80 mg/kg of b. w.).
1021
1022 </p>
1023 </div>
1024
1025
1026
1027
1028
1029
1030
1031
1032
1033
1034
1035
1036 <div align="justify">
1037 <p style="text-align: justify;">
1038
1039
1040
1041 </p>
1042 </div>
1043
1044
1045
1046
1047
1048
1049
1050
1051
1052
1053
1054
1055 <div align="justify">
1056 <p style="text-align: justify;">
1057
1058 Fish are usually treated over 10 consecutive days.
1059
1060 </p>
1061 </div>
1062
1063
1064
1065
1066
1067
1068
1069
1070
1071
1072
1073
1074 <div align="justify">
1075 <p style="text-align: justify;">
1076
1077
1078
1079 </p>
1080 </div>
1081
1082
1083
1084
1085
1086
1087
1088
1089
1090
1091
1092
1093 <div align="justify">
1094 <p style="text-align: justify;">
1095
1096 <b><i>Warnings and precautions</i></b>
1097
1098 </p>
1099 </div>
1100
1101
1102
1103
1104
1105
1106
1107
1108
1109
1110
1111
1112 <div align="justify">
1113 <p style="text-align: justify;">
1114
1115 If given in drinking water, the preparation should be completely dissolved.
1116
1117 </p>
1118 </div>
1119
1120
1121
1122
1123
1124
1125
1126
1127
1128
1129
1130
1131 <div align="justify">
1132 <p style="text-align: justify;">
1133
1134
1135
1136 </p>
1137 </div>
1138
1139
1140
1141
1142
1143
1144
1145
1146
1147
1148
1149
1150 <div align="justify">
1151 <p style="text-align: justify;">
1152
1153 Always prepare a fresh solution, which should be the only source of drinking water.
1154
1155 </p>
1156 </div>
1157
1158
1159
1160
1161
1162
1163
1164
1165
1166
1167
1168
1169 <div align="justify">
1170 <p style="text-align: justify;">
1171
1172
1173
1174 </p>
1175 </div>
1176
1177
1178
1179
1180
1181
1182
1183
1184
1185
1186
1187
1188 <div align="justify">
1189 <p style="text-align: justify;">
1190
1191 <b><i>Side effects</i></b><b></b>
1192
1193 </p>
1194 </div>
1195
1196
1197
1198
1199
1200
1201
1202
1203
1204
1205
1206
1207 <div align="justify">
1208 <p style="text-align: justify;">
1209
1210 In adult ruminants a long-time administration of tetracycline may cause transient disturbance of ruminal microflora and slightly decreased disintegration of cellulose.
1211
1212 </p>
1213 </div>
1214
1215
1216
1217
1218
1219
1220
1221
1222
1223
1224
1225
1226 <div align="justify">
1227 <p style="text-align: justify;">
1228
1229
1230
1231 </p>
1232 </div>
1233
1234
1235
1236
1237
1238
1239
1240
1241
1242
1243
1244
1245 <div align="justify">
1246 <p style="text-align: justify;">
1247
1248 <b><i>Withdrawal</i></b><b></b>
1249
1250 </p>
1251 </div>
1252
1253
1254
1255
1256
1257
1258
1259
1260
1261
1262
1263
1264 <div align="justify">
1265 <p style="text-align: justify;">
1266
1267 Meat, organs and other edible tissues
1268
1269 </p>
1270 </div>
1271
1272
1273
1274
1275
1276
1277
1278
1279
1280
1281
1282
1283 <div align="justify">
1284 <p style="text-align: justify;">
1285
1286 Calves, lambs, kids 10 days
1287
1288 </p>
1289 </div>
1290
1291
1292
1293
1294
1295
1296
1297
1298
1299
1300
1301
1302 <div align="justify">
1303 <p style="text-align: justify;">
1304
1305 Poultry and swine 7 days
1306
1307 </p>
1308 </div>
1309
1310
1311
1312
1313
1314
1315
1316
1317
1318
1319
1320
1321 <div align="justify">
1322 <p style="text-align: justify;">
1323
1324 Eggs 1 day
1325
1326 </p>
1327 </div>
1328
1329
1330
1331
1332
1333
1334
1335
1336
1337
1338
1339
1340 <div align="justify">
1341 <p style="text-align: justify;">
1342
1343
1344
1345 </p>
1346 </div>
1347
1348
1349
1350
1351
1352
1353
1354
1355
1356
1357
1358
1359 <div align="justify">
1360 <p style="text-align: justify;">
1361
1362 Withdrawal period for fish meat is 400 °D, i. e. 40 days when water temperature is 10°C and 20 days when water temperature is 20°C.
1363
1364 </p>
1365 </div>
1366
1367
1368
1369
1370
1371
1372
1373
1374
1375
1376
1377
1378 <div align="justify">
1379 <p style="text-align: justify;">
1380
1381
1382
1383 </p>
1384 </div>
1385
1386
1387
1388
1389
1390
1391
1392
1393
1394
1395
1396
1397 <div align="justify">
1398 <p style="text-align: justify;">
1399
1400 <b><i>Storage</i></b>
1401
1402 </p>
1403 </div>
1404
1405
1406
1407
1408
1409
1410
1411
1412
1413
1414
1415
1416 <div align="justify">
1417 <p style="text-align: justify;">
1418
1419 Store in a dry place at room temperature (up to 25°C). Keep away from children.
1420
1421 </p>
1422 </div>
1423
1424
1425
1426
1427
1428
1429
1430
1431
1432
1433
1434
1435 <div align="justify">
1436 <p style="text-align: justify;">
1437
1438
1439
1440 </p>
1441 </div>
1442
1443
1444
1445
1446
1447
1448
1449
1450
1451
1452
1453
1454 <div align="justify">
1455 <p style="text-align: justify;">
1456
1457 <b><i>Shelf life</i></b>
1458
1459 </p>
1460 </div>
1461
1462
1463
1464
1465
1466
1467
1468
1469
1470
1471
1472
1473 <div align="justify">
1474 <p style="text-align: justify;">
1475
1476 Denoted on the packaging (5 years in the original pack).
1477
1478 </p>
1479 </div>
1480
1481
1482
1483
1484
1485
1486
1487
1488
1489
1490
1491
1492 <div align="justify">
1493 <p style="text-align: justify;">
1494
1495 <b></b>
1496
1497 </p>
1498 </div>
1499
1500
1501
1502
1503
1504
1505
1506
1507
1508
1509
1510
1511 <div align="justify">
1512 <p style="text-align: justify;">
1513
1514 <b><i>Legal category</i></b>
1515
1516 </p>
1517 </div>
1518
1519
1520
1521
1522
1523
1524
1525
1526
1527
1528
1529
1530 <div align="justify">
1531 <p style="text-align: justify;">
1532
1533 On prescription only.
1534
1535 </p>
1536 </div>
1537
1538
1539
1540
1541
1542
1543
1544
1545
1546
1547
1548
1549 <div align="justify">
1550 <p style="text-align: justify;">
1551
1552
1553
1554 </p>
1555 </div>
1556
1557
1558
1559
1560
1561
1562
1563
1564
1565
1566
1567
1568 <div align="justify">
1569 <p style="text-align: justify;">
1570
1571 <b><i>Supply</i></b><b></b>
1572
1573 </p>
1574 </div>
1575
1576
1577
1578
1579
1580
1581
1582
1583
1584
1585
1586
1587 <div align="justify">
1588 <p style="text-align: justify;">
1589
1590 1 kg, 5 kg and 25 kg.
1591
1592 </p>
1593 </div>
1594
1595
1596
1597
1598
1599
1600
1601
1602
1603
1604
1605
1606 <div align="justify">
1607 <p style="text-align: justify;">
1608
1609
1610
1611 </p>
1612 </div>
1613
1614
1615
1616
1617
1618
1619
1620
1621
1622
1623
1624
1625 <div align="justify">
1626 <p style="text-align: justify;">
1627
1628 <b><i>Manufacturer</i></b><b></b>
1629
1630 </p>
1631 </div>
1632
1633
1634
1635
1636
1637
1638
1639
1640
1641
1642
1643
1644 <div align="justify">
1645 <p style="text-align: justify;">
1646
1647 VETERINA Animal Health Ltd., Croatia
1648
1649 </p>
1650 </div>
1651
1652
1653
1654
1655
1656
1657
1658
1659
1660
1661
1662
1663 <div align="justify">
1664 <p style="text-align: justify;">
1665
1666
1667
1668 </p>
1669 </div>
1670
1671
1672
1673
1674
1675
1676
1677
1678
1679
1680
1681
1682 <div align="left">
1683 <p style="text-align: left;">
1684
1685
1686
1687 </p>
1688 </div>
1689
1690
1691
1692
1693
1694
1695
1696 <!--Section Ends-->
1697
1698
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1704

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