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Revision 1.2 - (show annotations)
Tue Apr 10 11:02:10 2001 UTC (18 years ago) by dpavlin
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CVS Tags: HEAD
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1
2
3 <!--Section Begins--><br>
4
5
6
7
8
9
10 <div align="justify">
11 <p style="text-align: justify;">
12
13 <b>BENZAPEN</b><b><sup>®</sup></b>
14
15 </p>
16 </div>
17
18
19
20
21
22
23
24
25
26
27
28
29 <div align="justify">
30 <p style="text-align: justify;">
31
32 <i>injection suspension</i>
33
34 </p>
35 </div>
36
37
38
39
40
41
42
43
44
45
46
47
48 <div align="justify">
49 <p style="text-align: justify;">
50
51
52
53 </p>
54 </div>
55
56
57
58
59
60
61
62
63
64
65
66
67 <div align="justify">
68 <p style="text-align: justify;">
69
70 <b><i>Composition</i></b>
71
72 </p>
73 </div>
74
75
76
77
78
79
80
81
82
83
84
85
86 <div align="justify">
87 <p style="text-align: justify;">
88
89 1 mL contains:
90
91 </p>
92 </div>
93
94
95
96
97
98
99
100
101
102
103
104
105 <div align="justify">
106 <p style="text-align: justify;">
107
108 Benzathine benzylpenicillin 150,000 iu
109
110 </p>
111 </div>
112
113
114
115
116
117
118
119
120
121
122
123
124 <div align="justify">
125 <p style="text-align: justify;">
126
127 Procaine benzylpenicillin 150,000 iu
128
129 </p>
130 </div>
131
132
133
134
135
136
137
138
139
140
141
142
143 <div align="justify">
144 <p style="text-align: justify;">
145
146
147
148 </p>
149 </div>
150
151
152
153
154
155
156
157
158
159
160
161
162 <div align="justify">
163 <p style="text-align: justify;">
164
165 <b><i>Action</i></b><b></b>
166
167 </p>
168 </div>
169
170
171
172
173
174
175
176
177
178
179
180
181 <div align="justify">
182 <p style="text-align: justify;">
183
184 Benzapen<b><sup>®</sup></b> is a sterile ready-to-use penicillin suspension. A combined action of procaine benzylpenicillin and benzathine benzylpenicillin ensures efficient blood levels of the drug and its prolonged action. Therapeutic concentrations after a single injection of Benzapen<b><sup>®</sup></b> are maintained over 3-4 days. Owing to these properties usually one injection is sufficient for treatment, which makes Benzapen<b><sup>®</sup></b> a very suitable and cost-effective drug in veterinary practice.
185
186 </p>
187 </div>
188
189
190
191
192
193
194
195
196
197
198
199
200 <div align="justify">
201 <p style="text-align: justify;">
202
203
204
205 </p>
206 </div>
207
208
209
210
211
212
213
214
215
216
217
218
219 <div align="justify">
220 <p style="text-align: justify;">
221
222 <b><i>Indications</i></b>
223
224 </p>
225 </div>
226
227
228
229
230
231
232
233
234
235
236
237
238 <div align="justify">
239 <p style="text-align: justify;">
240
241 General and local infections caused by penicillin-sensitive pathogens, particularly streptococci and staphylococci, diplococci and pneumococci;
242
243 </p>
244 </div>
245
246
247
248
249
250
251
252
253
254
255
256
257 <div align="justify">
258 <p style="text-align: justify;">
259
260
261
262 </p>
263 </div>
264
265
266
267
268
269
270
271
272
273
274
275
276 <div align="justify">
277 <p style="text-align: justify;">
278
279 specific infections: swine erysipelas, anthrax, leptospirosis, malignant edema, tetanus and actinomycosis;
280
281 </p>
282 </div>
283
284
285
286
287
288
289
290
291
292
293
294
295 <div align="justify">
296 <p style="text-align: justify;">
297
298
299
300 </p>
301 </div>
302
303
304
305
306
307
308
309
310
311
312
313
314 <div align="justify">
315 <p style="text-align: justify;">
316
317 bacterial infections secondary to and following viral diseases (viral bronchopneumonia, equine influenza, canine distemper, etc.);
318
319 </p>
320 </div>
321
322
323
324
325
326
327
328
329
330
331
332
333 <div align="justify">
334 <p style="text-align: justify;">
335
336
337
338 </p>
339 </div>
340
341
342
343
344
345
346
347
348
349
350
351
352 <div align="justify">
353 <p style="text-align: justify;">
354
355 puerperal infections, metritis, mastitis, phlegmona, pyodermia, abscess, infected wounds, burns, paronychia, acute suppurative arthritis and umbilical infections.
356
357 </p>
358 </div>
359
360
361
362
363
364
365
366
367
368
369
370
371 <div align="justify">
372 <p style="text-align: justify;">
373
374
375
376 </p>
377 </div>
378
379
380
381
382
383
384
385
386
387
388
389
390 <div align="justify">
391 <p style="text-align: justify;">
392
393 In prophylaxis Benzapen<b><sup>®</sup></b> is given prior to surgical operations and parturition.
394
395 </p>
396 </div>
397
398
399
400
401
402
403
404
405
406
407
408
409 <div align="justify">
410 <p style="text-align: justify;">
411
412
413
414 </p>
415 </div>
416
417
418
419
420
421
422
423
424
425
426
427
428 <div align="justify">
429 <p style="text-align: justify;">
430
431 <b><i>Contraindications</i></b><b></b>
432
433 </p>
434 </div>
435
436
437
438
439
440
441
442
443
444
445
446
447 <div align="justify">
448 <p style="text-align: justify;">
449
450 Benzapen<b><sup>®</sup></b> should not be administered by i. v. route.
451
452 </p>
453 </div>
454
455
456
457
458
459
460
461
462
463
464
465
466 <div align="justify">
467 <p style="text-align: justify;">
468
469
470
471 </p>
472 </div>
473
474
475
476
477
478
479
480
481
482
483
484
485 <div align="justify">
486 <p style="text-align: justify;">
487
488 Hypersensitivity to penicillin antibiotics, which is quite uncommon.
489
490 </p>
491 </div>
492
493
494
495
496
497
498
499
500
501
502
503
504 <div align="justify">
505 <p style="text-align: justify;">
506
507
508
509 </p>
510 </div>
511
512
513
514
515
516
517
518
519
520
521
522
523 <div align="justify">
524 <p style="text-align: justify;">
525
526 Beta-lactam antibiotics should not be administered to guinea-pigs, hamsters, rabbits and other small monogastric herbivore in which they can cause clostridiotoxicosis and fatal entercholitis.
527
528 </p>
529 </div>
530
531
532
533
534
535
536
537
538
539
540
541
542 <div align="justify">
543 <p style="text-align: justify;">
544
545
546
547 </p>
548 </div>
549
550
551
552
553
554
555
556
557
558
559
560
561 <div align="justify">
562 <p style="text-align: justify;">
563
564 <b><i>Administration and dosage</i></b>
565
566 </p>
567 </div>
568
569
570
571
572
573
574
575
576
577
578
579
580 <div align="justify">
581 <p style="text-align: justify;">
582
583 Shake well before use.
584
585 </p>
586 </div>
587
588
589
590
591
592
593
594
595
596
597
598
599 <div align="justify">
600 <p style="text-align: justify;">
601
602 Benzapen<b><sup>®</sup></b> is given by i. m. route only.
603
604 </p>
605 </div>
606
607
608
609
610
611
612
613
614
615
616
617
618 <div align="justify">
619 <p style="text-align: justify;">
620
621
622
623 </p>
624 </div>
625
626
627
628
629
630
631
632
633
634
635
636
637 <div align="justify">
638 <p style="text-align: justify;">
639
640 Horses, cattle, sheep, goats and swine: 1 mL/25 kg of b. w. (11,000 iu/kg of b. w.).
641
642 </p>
643 </div>
644
645
646
647
648
649
650
651
652
653
654
655
656 <div align="justify">
657 <p style="text-align: justify;">
658
659
660
661 </p>
662 </div>
663
664
665
666
667
668
669
670
671
672
673
674
675 <div align="justify">
676 <p style="text-align: justify;">
677
678 Dogs and cats: 1 mL/10 kg of b. w. (28,750 iu/kg of b. w.).
679
680 </p>
681 </div>
682
683
684
685
686
687
688
689
690
691
692
693
694 <div align="justify">
695 <p style="text-align: justify;">
696
697
698
699 </p>
700 </div>
701
702
703
704
705
706
707
708
709
710
711
712
713 <div align="justify">
714 <p style="text-align: justify;">
715
716 The above doses are for single administration. If necessary, repeat after 3, but not more than 4 days.
717
718 </p>
719 </div>
720
721
722
723
724
725
726
727
728
729
730
731
732 <div align="justify">
733 <p style="text-align: justify;">
734
735
736
737 </p>
738 </div>
739
740
741
742
743
744
745
746
747 <table width="82.36%" border="1" cols="3" rows="6">
748 <tr>
749 <td bgcolor="White" width="54.19%" rowspan="1" colspan="1">
750
751 <div align="left">
752 <p style="text-align: left;">
753
754 Species
755
756 </p>
757 </div>
758
759
760
761
762 </td>
763
764
765
766
767
768 <td bgcolor="White" width="25.90%" rowspan="1" colspan="1">
769
770 <div align="left">
771 <p style="text-align: left;">
772
773 Body weight
774
775 </p>
776 </div>
777
778
779
780
781 </td>
782
783
784
785
786
787 <td bgcolor="White" width="19.91%" rowspan="1" colspan="1">
788
789 <div align="left">
790 <p style="text-align: left;">
791
792 Dose
793
794 </p>
795 </div>
796
797
798
799
800 </td>
801
802
803
804
805
806
807
808 </tr>
809
810
811
812 <tr>
813 <td bgcolor="White" width="54.19%" rowspan="1" colspan="1">
814
815 <div align="left">
816 <p style="text-align: left;">
817
818 Horses
819
820 </p>
821 </div>
822
823
824
825
826 </td>
827
828
829
830
831
832 <td bgcolor="White" width="25.90%" rowspan="1" colspan="1">
833
834 <div align="left">
835 <p style="text-align: left;">
836
837 500 kg
838
839 </p>
840 </div>
841
842
843
844
845 </td>
846
847
848
849
850
851 <td bgcolor="White" width="19.91%" rowspan="1" colspan="1">
852
853 <div align="left">
854 <p style="text-align: left;">
855
856 20 mL
857
858 </p>
859 </div>
860
861
862
863
864 </td>
865
866
867
868
869
870
871
872 </tr>
873
874
875
876 <tr>
877 <td bgcolor="White" width="54.19%" rowspan="1" colspan="1">
878
879 <div align="left">
880 <p style="text-align: left;">
881
882 Cattle
883
884 </p>
885 </div>
886
887
888
889
890 </td>
891
892
893
894
895
896 <td bgcolor="White" width="25.90%" rowspan="1" colspan="1">
897
898 <div align="left">
899 <p style="text-align: left;">
900
901 400 kg
902
903 </p>
904 </div>
905
906
907
908
909 </td>
910
911
912
913
914
915 <td bgcolor="White" width="19.91%" rowspan="1" colspan="1">
916
917 <div align="left">
918 <p style="text-align: left;">
919
920 16 mL
921
922 </p>
923 </div>
924
925
926
927
928 </td>
929
930
931
932
933
934
935
936 </tr>
937
938
939
940 <tr>
941 <td bgcolor="White" width="54.19%" rowspan="1" colspan="1">
942
943 <div align="left">
944 <p style="text-align: left;">
945
946 Calves, sheep, swine
947
948 </p>
949 </div>
950
951
952
953
954 </td>
955
956
957
958
959
960 <td bgcolor="White" width="25.90%" rowspan="1" colspan="1">
961
962 <div align="left">
963 <p style="text-align: left;">
964
965 50 kg
966
967 </p>
968 </div>
969
970
971
972
973 </td>
974
975
976
977
978
979 <td bgcolor="White" width="19.91%" rowspan="1" colspan="1">
980
981 <div align="left">
982 <p style="text-align: left;">
983
984 2 mL
985
986 </p>
987 </div>
988
989
990
991
992 </td>
993
994
995
996
997
998
999
1000 </tr>
1001
1002
1003
1004 <tr>
1005 <td bgcolor="White" width="54.19%" rowspan="1" colspan="1">
1006
1007 <div align="left">
1008 <p style="text-align: left;">
1009
1010 Dogs
1011
1012 </p>
1013 </div>
1014
1015
1016
1017
1018 </td>
1019
1020
1021
1022
1023
1024 <td bgcolor="White" width="25.90%" rowspan="1" colspan="1">
1025
1026 <div align="left">
1027 <p style="text-align: left;">
1028
1029 10 kg
1030
1031 </p>
1032 </div>
1033
1034
1035
1036
1037 </td>
1038
1039
1040
1041
1042
1043 <td bgcolor="White" width="19.91%" rowspan="1" colspan="1">
1044
1045 <div align="left">
1046 <p style="text-align: left;">
1047
1048 1 mL
1049
1050 </p>
1051 </div>
1052
1053
1054
1055
1056 </td>
1057
1058
1059
1060
1061
1062
1063
1064 </tr>
1065
1066
1067
1068 <tr>
1069 <td bgcolor="White" width="54.19%" rowspan="1" colspan="1">
1070
1071 <div align="left">
1072 <p style="text-align: left;">
1073
1074 Cats
1075
1076 </p>
1077 </div>
1078
1079
1080
1081
1082 </td>
1083
1084
1085
1086
1087
1088 <td bgcolor="White" width="25.90%" rowspan="1" colspan="1">
1089
1090 <div align="left">
1091 <p style="text-align: left;">
1092
1093 5 kg
1094
1095 </p>
1096 </div>
1097
1098
1099
1100
1101 </td>
1102
1103
1104
1105
1106
1107 <td bgcolor="White" width="19.91%" rowspan="1" colspan="1">
1108
1109 <div align="left">
1110 <p style="text-align: left;">
1111
1112 0.5 mL
1113
1114 </p>
1115 </div>
1116
1117
1118
1119
1120 </td>
1121
1122
1123
1124
1125
1126
1127
1128 </tr>
1129
1130 </table>
1131
1132
1133
1134
1135 <div align="justify">
1136 <p style="text-align: justify;">
1137
1138
1139
1140 </p>
1141 </div>
1142
1143
1144
1145
1146
1147
1148
1149
1150
1151
1152
1153
1154 <div align="justify">
1155 <p style="text-align: justify;">
1156
1157 <b><i>Side effects</i></b><b></b>
1158
1159 </p>
1160 </div>
1161
1162
1163
1164
1165
1166
1167
1168
1169
1170
1171
1172
1173 <div align="justify">
1174 <p style="text-align: justify;">
1175
1176 Penicillin injection suspensions that combine procaine benzylpenicillin and benzathine benzylpenicillin produce side effects on extremely rare occasions.
1177
1178 </p>
1179 </div>
1180
1181
1182
1183
1184
1185
1186
1187
1188
1189
1190
1191
1192 <div align="justify">
1193 <p style="text-align: justify;">
1194
1195
1196
1197 </p>
1198 </div>
1199
1200
1201
1202
1203
1204
1205
1206
1207
1208
1209
1210
1211 <div align="justify">
1212 <p style="text-align: justify;">
1213
1214 <b><i>Warnings and precautions</i></b><b></b>
1215
1216 </p>
1217 </div>
1218
1219
1220
1221
1222
1223
1224
1225
1226
1227
1228
1229
1230 <div align="justify">
1231 <p style="text-align: justify;">
1232
1233 To avoid local tissue irritation, the dose injected to large animals should not exceed 20 mL.
1234
1235 </p>
1236 </div>
1237
1238
1239
1240
1241
1242
1243
1244
1245
1246
1247
1248
1249 <div align="justify">
1250 <p style="text-align: justify;">
1251
1252
1253
1254 </p>
1255 </div>
1256
1257
1258
1259
1260
1261
1262
1263
1264
1265
1266
1267
1268 <div align="justify">
1269 <p style="text-align: justify;">
1270
1271 Benzylpenicillin preparations are not active against beta-lactamase producing organisms.
1272
1273 </p>
1274 </div>
1275
1276
1277
1278
1279
1280
1281
1282
1283
1284
1285
1286
1287 <div align="justify">
1288 <p style="text-align: justify;">
1289
1290
1291
1292 </p>
1293 </div>
1294
1295
1296
1297
1298
1299
1300
1301
1302
1303
1304
1305
1306 <div align="justify">
1307 <p style="text-align: justify;">
1308
1309 Concurrent administration of tetracycline and/or macrolide antibiotics with penicillin may diminish antimicrobial action of penicillin.
1310
1311 </p>
1312 </div>
1313
1314
1315
1316
1317
1318
1319
1320
1321
1322
1323
1324
1325 <div align="justify">
1326 <p style="text-align: justify;">
1327
1328
1329
1330 </p>
1331 </div>
1332
1333
1334
1335
1336
1337
1338
1339
1340
1341
1342
1343
1344 <div align="justify">
1345 <p style="text-align: justify;">
1346
1347 In case of allergic reactions (skin changes, urticaria, anaphylactic shock, etc.) institute appropriate treatment (adrenaline, glucocorticoids, antihistaminics).
1348
1349 </p>
1350 </div>
1351
1352
1353
1354
1355
1356
1357
1358
1359
1360
1361
1362
1363 <div align="justify">
1364 <p style="text-align: justify;">
1365
1366
1367
1368 </p>
1369 </div>
1370
1371
1372
1373
1374
1375
1376
1377
1378
1379
1380
1381
1382 <div align="justify">
1383 <p style="text-align: justify;">
1384
1385 <b><i>Withdrawal</i></b>
1386
1387 </p>
1388 </div>
1389
1390
1391
1392
1393
1394
1395
1396
1397
1398
1399
1400
1401 <div align="justify">
1402 <p style="text-align: justify;">
1403
1404 Meat, organs and other edible tissues 21 days
1405
1406 </p>
1407 </div>
1408
1409
1410
1411
1412
1413
1414
1415
1416
1417
1418
1419
1420 <div align="justify">
1421 <p style="text-align: justify;">
1422
1423 Milk 10 days
1424
1425 </p>
1426 </div>
1427
1428
1429
1430
1431
1432
1433
1434
1435
1436
1437
1438
1439 <div align="justify">
1440 <p style="text-align: justify;">
1441
1442
1443
1444 </p>
1445 </div>
1446
1447
1448
1449
1450
1451
1452
1453
1454
1455
1456
1457
1458 <div align="justify">
1459 <p style="text-align: justify;">
1460
1461 <b><i>Storage</i></b><b> </b>
1462
1463 </p>
1464 </div>
1465
1466
1467
1468
1469
1470
1471
1472
1473
1474
1475
1476
1477 <div align="justify">
1478 <p style="text-align: justify;">
1479
1480 Store in a cool and dark place, up to 15°C. Keep away from children. Avoid freezing.
1481
1482 </p>
1483 </div>
1484
1485
1486
1487
1488
1489
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1491
1492
1493
1494
1495
1496 <div align="justify">
1497 <p style="text-align: justify;">
1498
1499
1500
1501 </p>
1502 </div>
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1504
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1507
1508
1509
1510
1511
1512
1513
1514
1515 <div align="justify">
1516 <p style="text-align: justify;">
1517
1518 <b><i>Shelf life</i></b><b></b>
1519
1520 </p>
1521 </div>
1522
1523
1524
1525
1526
1527
1528
1529
1530
1531
1532
1533
1534 <div align="justify">
1535 <p style="text-align: justify;">
1536
1537 Denoted on the packaging (2 years in the original pack).
1538
1539 </p>
1540 </div>
1541
1542
1543
1544
1545
1546
1547
1548
1549
1550
1551
1552
1553 <div align="justify">
1554 <p style="text-align: justify;">
1555
1556
1557
1558 </p>
1559 </div>
1560
1561
1562
1563
1564
1565
1566
1567
1568
1569
1570
1571
1572 <div align="justify">
1573 <p style="text-align: justify;">
1574
1575 <b><i>Legal category</i></b><b></b>
1576
1577 </p>
1578 </div>
1579
1580
1581
1582
1583
1584
1585
1586
1587
1588
1589
1590
1591 <div align="justify">
1592 <p style="text-align: justify;">
1593
1594 On prescription only.
1595
1596 </p>
1597 </div>
1598
1599
1600
1601
1602
1603
1604
1605
1606
1607
1608
1609
1610 <div align="justify">
1611 <p style="text-align: justify;">
1612
1613 <b><i></i></b>
1614
1615 </p>
1616 </div>
1617
1618
1619
1620
1621
1622
1623
1624
1625
1626
1627
1628
1629 <div align="justify">
1630 <p style="text-align: justify;">
1631
1632 Supply<b></b>
1633
1634 </p>
1635 </div>
1636
1637
1638
1639
1640
1641
1642
1643
1644
1645
1646
1647
1648 <div align="justify">
1649 <p style="text-align: justify;">
1650
1651 Bottles with 50 mL and 100 mL.
1652
1653 </p>
1654 </div>
1655
1656
1657
1658
1659
1660
1661
1662
1663
1664
1665
1666
1667 <div align="justify">
1668 <p style="text-align: justify;">
1669
1670
1671
1672 </p>
1673 </div>
1674
1675
1676
1677
1678
1679
1680
1681
1682
1683
1684
1685
1686 <div align="justify">
1687 <p style="text-align: justify;">
1688
1689 <b><i>Manufacturer</i></b><b></b>
1690
1691 </p>
1692 </div>
1693
1694
1695
1696
1697
1698
1699
1700
1701
1702
1703
1704
1705 <div align="justify">
1706 <p style="text-align: justify;">
1707
1708 VETERINA Animal Health Ltd., Croatia
1709
1710 </p>
1711 </div>
1712
1713
1714
1715
1716
1717
1718
1719
1720
1721
1722
1723
1724 <div align="justify">
1725 <p style="text-align: justify;">
1726
1727
1728
1729 </p>
1730 </div>
1731
1732
1733
1734
1735
1736
1737
1738
1739
1740
1741
1742
1743 <div align="left">
1744 <p style="text-align: left;">
1745
1746
1747
1748 </p>
1749 </div>
1750
1751
1752
1753
1754
1755
1756
1757 <!--Section Ends-->
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