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Revision 1.2 - (show annotations)
Tue Apr 10 11:02:10 2001 UTC (18 years ago) by dpavlin
Branch: MAIN
CVS Tags: HEAD
Changes since 1.1: +4 -4 lines
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1
2
3 <!--Section Begins--><br>
4
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9
10 <div align="justify">
11 <p style="text-align: justify;">
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15 </p>
16 </div>
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26
27
28
29 <div align="justify">
30 <p style="text-align: justify;">
31
32 <b>PESTIKAL</b><b><sup>®</sup></b><b> B</b><b><sub>1</sub></b><b> SPF</b>
33
34 </p>
35 </div>
36
37
38
39
40
41
42
43
44
45
46
47
48 <div align="justify">
49 <p style="text-align: justify;">
50
51 <i>lyophilised vaccine against Newcastle disease Hitchner B</i><i><sub>1</sub></i><i> strain for chicks, hens and turkeys </i>
52
53 </p>
54 </div>
55
56
57
58
59
60
61
62
63
64
65
66
67 <div align="justify">
68 <p style="text-align: justify;">
69
70 <b></b>
71
72 </p>
73 </div>
74
75
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84
85
86 <div align="justify">
87 <p style="text-align: justify;">
88
89 <b><i>Composition</i></b>
90
91 </p>
92 </div>
93
94
95
96
97
98
99
100
101
102
103
104
105 <div align="justify">
106 <p style="text-align: justify;">
107
108 The vaccine contains live lentogenic Newcastle disease virus Hitchner B<sub>1</sub> strain grown in chicks' embryos obtained from SPF eggs. One vaccinal dose contains at least 10<sup>6.0 </sup>EID<sub>50</sub> of this lentogenic virus.
109
110 </p>
111 </div>
112
113
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115
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117
118
119
120
121
122
123
124 <div align="justify">
125 <p style="text-align: justify;">
126
127
128
129 </p>
130 </div>
131
132
133
134
135
136
137
138
139
140
141
142
143 <div align="justify">
144 <p style="text-align: justify;">
145
146 <b><i>Action</i></b><b></b>
147
148 </p>
149 </div>
150
151
152
153
154
155
156
157
158
159
160
161
162 <div align="justify">
163 <p style="text-align: justify;">
164
165 The vaccine induces formation of specific antibodies for Newcastle disease in healthy birds.
166
167 </p>
168 </div>
169
170
171
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175
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179
180
181 <div align="justify">
182 <p style="text-align: justify;">
183
184
185
186 </p>
187 </div>
188
189
190
191
192
193
194
195
196
197
198
199
200 <div align="justify">
201 <p style="text-align: justify;">
202
203 <b><i>Indications</i></b>
204
205 </p>
206 </div>
207
208
209
210
211
212
213
214
215
216
217
218
219 <div align="justify">
220 <p style="text-align: justify;">
221
222 Immunisation of healthy chicks, hens and turkeys against Newcastle disease.
223
224 </p>
225 </div>
226
227
228
229
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231
232
233
234
235
236
237
238 <div align="justify">
239 <p style="text-align: justify;">
240
241
242
243 </p>
244 </div>
245
246
247
248
249
250
251
252
253
254
255
256
257 <div align="justify">
258 <p style="text-align: justify;">
259
260 <b><i>Contraindications</i></b>
261
262 </p>
263 </div>
264
265
266
267
268
269
270
271
272
273
274
275
276 <div align="justify">
277 <p style="text-align: justify;">
278
279 Unknown.
280
281 </p>
282 </div>
283
284
285
286
287
288
289
290
291
292
293
294
295 <div align="justify">
296 <p style="text-align: justify;">
297
298
299
300 </p>
301 </div>
302
303
304
305
306
307
308
309
310
311
312
313
314 <div align="justify">
315 <p style="text-align: justify;">
316
317 <b><i>Administration and dosage</i></b>
318
319 </p>
320 </div>
321
322
323
324
325
326
327
328
329
330
331
332
333 <div align="justify">
334 <p style="text-align: justify;">
335
336 PESTIKAL<b><sup>® </sup></b>B<sub>1</sub> SPF may be administered by the following three routes:
337
338 </p>
339 </div>
340
341
342
343
344
345
346
347
348
349
350
351
352 <div align="justify">
353 <p style="text-align: justify;">
354
355
356
357 </p>
358 </div>
359
360
361
362
363
364
365
366
367
368
369
370
371 <div align="justify">
372 <p style="text-align: justify;">
373
374 <b><i>1. Oculonasally</i></b><b></b>
375
376 </p>
377 </div>
378
379
380
381
382
383
384
385
386
387
388
389
390 <div align="justify">
391 <p style="text-align: justify;">
392
393 One dose of reconstituted vaccine is 0.1 mL, i. e. about two drops, irrespective of the age and body weight. The vaccine is administered dropwise into the eye and nostril.
394
395 </p>
396 </div>
397
398
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401
402
403
404
405
406
407
408
409 <div align="justify">
410 <p style="text-align: justify;">
411
412
413
414 </p>
415 </div>
416
417
418
419
420
421
422
423
424
425
426
427
428 <div align="justify">
429 <p style="text-align: justify;">
430
431 <b><i>2. In drinking water</i></b>
432
433 </p>
434 </div>
435
436
437
438
439
440
441
442
443
444
445
446
447 <div align="justify">
448 <p style="text-align: justify;">
449
450 Immediately before use, the vaccine should be reconstituted in cold and clean water without chlorine or other disinfectants, in the dosage equivalent to the number of birds to be vaccinated.
451
452 </p>
453 </div>
454
455
456
457
458
459
460
461
462
463
464
465
466 <div align="justify">
467 <p style="text-align: justify;">
468
469
470
471 </p>
472 </div>
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474
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476
477
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479
480
481
482
483
484
485 <div align="justify">
486 <p style="text-align: justify;">
487
488 Use 10 L of water to reconstitute 1000 vaccinal doses for the chicks in the first week of life, 20 L of water for the chicks aged 2-3 weeks and 40 L of water for two months old and older birds.
489
490 </p>
491 </div>
492
493
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495
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498
499
500
501
502
503
504 <div align="justify">
505 <p style="text-align: justify;">
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507
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509 </p>
510 </div>
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519
520
521
522
523 <div align="justify">
524 <p style="text-align: justify;">
525
526 To make the birds thirsty withhold normal supplies of water 3 hours prior to immunisation. Waterers should be clean, with no traces of food or disinfectant.
527
528 </p>
529 </div>
530
531
532
533
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539
540
541
542 <div align="justify">
543 <p style="text-align: justify;">
544
545
546
547 </p>
548 </div>
549
550
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555
556
557
558
559
560
561 <div align="justify">
562 <p style="text-align: justify;">
563
564 Sufficient number of waterers should be provided, i. e. about 30% more than required for that age, to ensure that all birds take the water with the vaccine within one hour.
565
566 </p>
567 </div>
568
569
570
571
572
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574
575
576
577
578
579
580 <div align="justify">
581 <p style="text-align: justify;">
582
583
584
585 </p>
586 </div>
587
588
589
590
591
592
593
594
595
596
597
598
599 <div align="justify">
600 <p style="text-align: justify;">
601
602 <b><i>3. Spraying</i></b>
603
604 </p>
605 </div>
606
607
608
609
610
611
612
613
614
615
616
617
618 <div align="justify">
619 <p style="text-align: justify;">
620
621 Spraying ensures fast establishment of sound immunity and is, therefore, recommended when the flock is in the imminent risk of infection. Vaccination is performed with a sprayer forming 30-100 mm size particles. The particles for the chicks are larger than for older birds.
622
623 </p>
624 </div>
625
626
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629
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631
632
633
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635
636
637 <div align="justify">
638 <p style="text-align: justify;">
639
640
641
642 </p>
643 </div>
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654
655
656 <div align="justify">
657 <p style="text-align: justify;">
658
659 Number of doses should correspond to the number of birds in a flock. Reconstitute 1000 doses of the vaccine in 100-150 mL of, preferably, distilled water. Prior to vaccination confine the birds to a smaller area and disconnect the ventilation. If the birds are in the cages or boxes, spray the vaccine directly over them.
660
661 </p>
662 </div>
663
664
665
666
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669
670
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675 <div align="justify">
676 <p style="text-align: justify;">
677
678
679
680 </p>
681 </div>
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690
691
692
693
694 <div align="justify">
695 <p style="text-align: justify;">
696
697 Over 4 days upon vaccination it is recommended to give the birds the drugs for prevention of bacterial and mycoplasmal infections, particularly if the vaccine is sprayed over the flock with latent infection.
698
699 </p>
700 </div>
701
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709
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711
712
713 <div align="justify">
714 <p style="text-align: justify;">
715
716
717
718 </p>
719 </div>
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723
724
725
726
727
728
729
730
731
732 <div align="justify">
733 <p style="text-align: justify;">
734
735 <b><i>Immunity</i></b><b></b>
736
737 </p>
738 </div>
739
740
741
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743
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745
746
747
748
749
750
751 <div align="justify">
752 <p style="text-align: justify;">
753
754 Immunity is developed on about day 5-6 post vaccination and is fully established on day 21. The younger the poultry, the shorter duration immunity. Adult, multiply vaccinated birds maintain immunity over 3-5 months.
755
756 </p>
757 </div>
758
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761
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764
765
766
767
768
769
770 <div align="justify">
771 <p style="text-align: justify;">
772
773
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775 </p>
776 </div>
777
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780
781
782
783
784
785
786
787
788
789 <div align="justify">
790 <p style="text-align: justify;">
791
792 <b><i>Warnings and precautions</i></b>
793
794 </p>
795 </div>
796
797
798
799
800
801
802
803
804
805
806
807
808 <div align="justify">
809 <p style="text-align: justify;">
810
811 Vaccinate only healthy birds.
812
813 </p>
814 </div>
815
816
817
818
819
820
821
822
823
824
825
826
827 <div align="justify">
828 <p style="text-align: justify;">
829
830 <b><i></i></b>
831
832 </p>
833 </div>
834
835
836
837
838
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840
841
842
843
844
845
846 <div align="justify">
847 <p style="text-align: justify;">
848
849 Once resuspended use within 3 hours.
850
851 </p>
852 </div>
853
854
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856
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859
860
861
862
863
864
865 <div align="justify">
866 <p style="text-align: justify;">
867
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869
870 </p>
871 </div>
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880
881
882
883
884 <div align="justify">
885 <p style="text-align: justify;">
886
887 Live vaccine against Newcastle disease very rarely causes conjunctivitis in humans. It is, therefore, recommended to wear a protective mask during spraying.
888
889 </p>
890 </div>
891
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902
903 <div align="justify">
904 <p style="text-align: justify;">
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908 </p>
909 </div>
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920
921
922 <div align="justify">
923 <p style="text-align: justify;">
924
925 <b><i>Withdrawal</i></b>
926
927 </p>
928 </div>
929
930
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934
935
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937
938
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940
941 <div align="justify">
942 <p style="text-align: justify;">
943
944 Meat, organs and other edible tissues - 0 days.
945
946 </p>
947 </div>
948
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950
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956
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960 <div align="justify">
961 <p style="text-align: justify;">
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964
965 </p>
966 </div>
967
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978
979 <div align="justify">
980 <p style="text-align: justify;">
981
982 <b><i>Storage</i></b>
983
984 </p>
985 </div>
986
987
988
989
990
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992
993
994
995
996
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998 <div align="justify">
999 <p style="text-align: justify;">
1000
1001 Store in the refrigerator at 2-8°C. Keep away from children.
1002
1003 </p>
1004 </div>
1005
1006
1007
1008
1009
1010
1011
1012
1013
1014
1015
1016
1017 <div align="justify">
1018 <p style="text-align: justify;">
1019
1020
1021
1022 </p>
1023 </div>
1024
1025
1026
1027
1028
1029
1030
1031
1032
1033
1034
1035
1036 <div align="justify">
1037 <p style="text-align: justify;">
1038
1039 <b><i>Shelf life</i></b>
1040
1041 </p>
1042 </div>
1043
1044
1045
1046
1047
1048
1049
1050
1051
1052
1053
1054
1055 <div align="justify">
1056 <p style="text-align: justify;">
1057
1058 Denoted on the packaging (2 years).
1059
1060 </p>
1061 </div>
1062
1063
1064
1065
1066
1067
1068
1069
1070
1071
1072
1073
1074 <div align="justify">
1075 <p style="text-align: justify;">
1076
1077 <b></b>
1078
1079 </p>
1080 </div>
1081
1082
1083
1084
1085
1086
1087
1088
1089
1090
1091
1092
1093 <div align="justify">
1094 <p style="text-align: justify;">
1095
1096 <b><i>Legal category</i></b><b></b>
1097
1098 </p>
1099 </div>
1100
1101
1102
1103
1104
1105
1106
1107
1108
1109
1110
1111
1112 <div align="justify">
1113 <p style="text-align: justify;">
1114
1115 On prescription only.
1116
1117 </p>
1118 </div>
1119
1120
1121
1122
1123
1124
1125
1126
1127
1128
1129
1130
1131 <div align="justify">
1132 <p style="text-align: justify;">
1133
1134 <b></b>
1135
1136 </p>
1137 </div>
1138
1139
1140
1141
1142
1143
1144
1145
1146
1147
1148
1149
1150 <div align="justify">
1151 <p style="text-align: justify;">
1152
1153 <b><i>Supply</i></b>
1154
1155 </p>
1156 </div>
1157
1158
1159
1160
1161
1162
1163
1164
1165
1166
1167
1168
1169 <div align="justify">
1170 <p style="text-align: justify;">
1171
1172 Box with 10x1000 doses and 10x2000 doses.
1173
1174 </p>
1175 </div>
1176
1177
1178
1179
1180
1181
1182
1183
1184
1185
1186
1187
1188 <div align="justify">
1189 <p style="text-align: justify;">
1190
1191
1192
1193 </p>
1194 </div>
1195
1196
1197
1198
1199
1200
1201
1202
1203
1204
1205
1206
1207 <div align="justify">
1208 <p style="text-align: justify;">
1209
1210 <b><i>Manufacturer</i></b><b></b>
1211
1212 </p>
1213 </div>
1214
1215
1216
1217
1218
1219
1220
1221
1222
1223
1224
1225
1226 <div align="justify">
1227 <p style="text-align: justify;">
1228
1229 VETERINA Animal Health Ltd., Croatia
1230
1231 </p>
1232 </div>
1233
1234
1235
1236
1237
1238
1239
1240
1241
1242
1243
1244
1245 <div align="justify">
1246 <p style="text-align: justify;">
1247
1248
1249
1250 </p>
1251 </div>
1252
1253
1254
1255
1256
1257
1258
1259
1260
1261
1262
1263
1264 <div align="justify">
1265 <p style="text-align: justify;">
1266
1267 <b><i>Important note</i></b>
1268
1269 </p>
1270 </div>
1271
1272
1273
1274
1275
1276
1277
1278
1279
1280
1281
1282
1283 <div align="justify">
1284 <p style="text-align: justify;">
1285
1286 In every animal population there are some with poorer response to vaccination. In addition to proper storage and administration, the success of vaccination depends on hereditary factors, age of the animal, subclinical diseases, titer of maternal antibodies, feeding, stress and concurrent administration of other medicines.<b></b>
1287
1288 </p>
1289 </div>
1290
1291
1292
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1297
1298
1299
1300
1301
1302 <div align="justify">
1303 <p style="text-align: justify;">
1304
1305
1306
1307 </p>
1308 </div>
1309
1310
1311
1312
1313
1314
1315
1316
1317
1318
1319
1320
1321 <div align="justify">
1322 <p style="text-align: justify;">
1323
1324 Given the variations in vaccination programmes, before vaccinating the whole flock it is recommended to consult the veterinarian - a poultry expert.<b></b>
1325
1326 </p>
1327 </div>
1328
1329
1330
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1332
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1335
1336
1337
1338
1339
1340 <div align="justify">
1341 <p style="text-align: justify;">
1342
1343
1344
1345 </p>
1346 </div>
1347
1348
1349
1350
1351
1352
1353
1354
1355
1356
1357
1358
1359 <div align="left">
1360 <p style="text-align: left;">
1361
1362
1363
1364 </p>
1365 </div>
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1370
1371
1372
1373 <!--Section Ends-->
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