corp_html/vet/1004.html



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<b>GUMBOKAL</b><b><sup>®</sup></b>

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<i>inactivated oily vaccine against Gumboro disease</i>

</p>
</div>


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<b></b>

</p>
</div>


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<b><i>Composition</i></b><b></b>

</p>
</div>


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The vaccine contains inactivated Gumboro disease virus grown in embryonated chicks' eggs, inactivated with formaldehyde and re-suspended, with the addition of an emulsifier, in mineral oil as a multiple emulsion water/oil/water type.

</p>
</div>


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</p>
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<b><i>Action</i></b><b></b>

</p>
</div>


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The vaccine stimulates formation of the specific antibodies for Gumboro disease virus.

</p>
</div>


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</p>
</div>


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<b><i>Indications</i></b>

</p>
</div>


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Immunoprophylaxis of healthy hybrids of light and heavy breeds against infectious bursal disease (Gumboro disease) and immunisation of their offspring during their first 2-4 weeks of life.

</p>
</div>


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</p>
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<b><i>Contraindications</i></b>

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Unknown.

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<b><i></i></b>

</p>
</div>


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Administration, dosage and vaccination programme<b></b>

</p>
</div>


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GUMBOKAL<b><sup>®</sup></b> is given by i. m<i>.</i> route into the breast muscle or s. c. into the skin fold at the dorsal neck side. The dose per bird is 0.5 mL. Before administration the vaccine should be heated to room temperature and shaken well prior to and occasionally during administration.

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</div>


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</p>
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As a rule, the birds are vaccinated at the age of 16-20 weeks.

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</p>
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Before being vaccinated with GUMBOKAL<b><sup>®</sup></b> the chicks should be given live vaccine against Gumboro disease. Time between these two vaccinations should not be shorter than 2 weeks. Optimum effect is achieved with an interval of 6 weeks.

</p>
</div>


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</p>
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<b><i>Immunity</i></b>

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In healthy chicks the immunity is established 2-3 weeks after vaccination and is maintained till the end of the production cycle. This ensures the immunity of their offspring against infectious bursal disease during their first 2-4 weeks of life.

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<b></b>

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<b><i>Warnings and precautions</i></b><b></b>

</p>
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The vaccine is administered to all birds in the flock. 

</p>
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</p>
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Once opened use within 24 hours. 

</p>
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</p>
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Packaging and vaccine leftovers must be disposed in a safe way.

</p>
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</p>
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Avoid direct exposure to sunlight and high temperatures.

</p>
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</p>
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Beware of accidental injecting into the hand. In severe local reaction seek medical advice (surgeon).

</p>
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</p>
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<b><i>Withdrawal</i></b>

</p>
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Meat, organs and other edible tissues of the vaccinated pullets - 0 days.

</p>
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<b></b>

</p>
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<b><i>Storage</i></b>

</p>
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Store in a dark place at 2-8°C (refrigerator). Keep away from children.  Avoid freezing. 

</p>
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</p>
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<b><i>Shelf life</i></b><b></b>

</p>
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Denoted on the packaging (18 months in the original pack).

</p>
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<p style="text-align: justify;">


</p>
</div>


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<b><i>Legal category</i></b><b></b>

</p>
</div>


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On prescription only.

</p>
</div>


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<p style="text-align: justify;">


</p>
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<b><i>Supply</i></b><b></b>

</p>
</div>


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Pierced bottle of 100 mL (200 doses) and 500 mL (1000 doses).

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</p>
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<b><i>Manufacturer</i></b><b></b>

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VETERINA Animal Health Ltd., Croatia

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<b><i>Important note</i></b><b></b>

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Infectious bursal disease virus (Gumboro disease) affects bursa of Fabricius, which is an important part of the chicks' immune system. Its infection markedly affects the bird's resistance to infectious diseases, particularly if occurs during the first 2 weeks of hatching. Infected chicks may have reduced immune response to other avian vaccines.

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In every animal population there are some with poorer response to vaccination. In addition to proper storage and administration, success of vaccination depends on hereditary factors, age of the animal, subclinical diseases, maternal antibodies, feed, stress factors and concurrent administration of other drugs.

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<!--Section Ends-->


1	dpavlin	1.1
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10			<div align="justify">
11			<p style="text-align: justify;">
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14
15			</p>
16			</div>
17
18
19
20
21
22
23
24
25
26
27
28
29			<div align="justify">
30			<p style="text-align: justify;">
31
32			<b>GUMBOKAL</b><b><sup>®</sup></b>
33
34			</p>
35			</div>
36
37
38
39
40
41
42
43
44
45
46
47
48			<div align="justify">
49			<p style="text-align: justify;">
50
51			<i>inactivated oily vaccine against Gumboro disease</i>
52
53			</p>
54			</div>
55
56
57
58
59
60
61
62
63
64
65
66
67			<div align="justify">
68			<p style="text-align: justify;">
69
70			<b></b>
71
72			</p>
73			</div>
74
75
76
77
78
79
80
81
82
83
84
85
86			<div align="justify">
87			<p style="text-align: justify;">
88
89			<b><i>Composition</i></b><b></b>
90
91			</p>
92			</div>
93
94
95
96
97
98
99
100
101
102
103
104
105			<div align="justify">
106			<p style="text-align: justify;">
107
108			The vaccine contains inactivated Gumboro disease virus grown in embryonated chicks' eggs, inactivated with formaldehyde and re-suspended, with the addition of an emulsifier, in mineral oil as a multiple emulsion water/oil/water type.
109
110			</p>
111			</div>
112
113
114
115
116
117
118
119
120
121
122
123
124			<div align="justify">
125			<p style="text-align: justify;">
126
127
128
129			</p>
130			</div>
131
132
133
134
135
136
137
138
139
140
141
142
143			<div align="justify">
144			<p style="text-align: justify;">
145
146			<b><i>Action</i></b><b></b>
147
148			</p>
149			</div>
150
151
152
153
154
155
156
157
158
159
160
161
162			<div align="justify">
163			<p style="text-align: justify;">
164
165			The vaccine stimulates formation of the specific antibodies for Gumboro disease virus.
166
167			</p>
168			</div>
169
170
171
172
173
174
175
176
177
178
179
180
181			<div align="justify">
182			<p style="text-align: justify;">
183
184
185
186			</p>
187			</div>
188
189
190
191
192
193
194
195
196
197
198
199
200			<div align="justify">
201			<p style="text-align: justify;">
202
203			<b><i>Indications</i></b>
204
205			</p>
206			</div>
207
208
209
210
211
212
213
214
215
216
217
218
219			<div align="justify">
220			<p style="text-align: justify;">
221
222			Immunoprophylaxis of healthy hybrids of light and heavy breeds against infectious bursal disease (Gumboro disease) and immunisation of their offspring during their first 2-4 weeks of life.
223
224			</p>
225			</div>
226
227
228
229
230
231
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233
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235
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237
238			<div align="justify">
239			<p style="text-align: justify;">
240
241
242
243			</p>
244			</div>
245
246
247
248
249
250
251
252
253
254
255
256
257			<div align="justify">
258			<p style="text-align: justify;">
259
260			<b><i>Contraindications</i></b>
261
262			</p>
263			</div>
264
265
266
267
268
269
270
271
272
273
274
275
276			<div align="justify">
277			<p style="text-align: justify;">
278
279			Unknown.
280
281			</p>
282			</div>
283
284
285
286
287
288
289
290
291
292
293
294
295			<div align="justify">
296			<p style="text-align: justify;">
297
298			<b><i></i></b>
299
300			</p>
301			</div>
302
303
304
305
306
307
308
309
310
311
312
313
314			<div align="justify">
315			<p style="text-align: justify;">
316
317			Administration, dosage and vaccination programme<b></b>
318
319			</p>
320			</div>
321
322
323
324
325
326
327
328
329
330
331
332
333			<div align="justify">
334			<p style="text-align: justify;">
335
336			GUMBOKAL<b><sup>®</sup></b> is given by i. m<i>.</i> route into the breast muscle or s. c. into the skin fold at the dorsal neck side. The dose per bird is 0.5 mL. Before administration the vaccine should be heated to room temperature and shaken well prior to and occasionally during administration.
337
338			</p>
339			</div>
340
341
342
343
344
345
346
347
348
349
350
351
352			<div align="justify">
353			<p style="text-align: justify;">
354
355
356
357			</p>
358			</div>
359
360
361
362
363
364
365
366
367
368
369
370
371			<div align="justify">
372			<p style="text-align: justify;">
373
374			As a rule, the birds are vaccinated at the age of 16-20 weeks.
375
376			</p>
377			</div>
378
379
380
381
382
383
384
385
386
387
388
389
390			<div align="justify">
391			<p style="text-align: justify;">
392
393
394
395			</p>
396			</div>
397
398
399
400
401
402
403
404
405
406
407
408
409			<div align="justify">
410			<p style="text-align: justify;">
411
412			Before being vaccinated with GUMBOKAL<b><sup>®</sup></b> the chicks should be given live vaccine against Gumboro disease. Time between these two vaccinations should not be shorter than 2 weeks. Optimum effect is achieved with an interval of 6 weeks.
413
414			</p>
415			</div>
416
417
418
419
420
421
422
423
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425
426
427
428			<div align="justify">
429			<p style="text-align: justify;">
430
431
432
433			</p>
434			</div>
435
436
437
438
439
440
441
442
443
444
445
446
447			<div align="justify">
448			<p style="text-align: justify;">
449
450			<b><i>Immunity</i></b>
451
452			</p>
453			</div>
454
455
456
457
458
459
460
461
462
463
464
465
466			<div align="justify">
467			<p style="text-align: justify;">
468
469			In healthy chicks the immunity is established 2-3 weeks after vaccination and is maintained till the end of the production cycle. This ensures the immunity of their offspring against infectious bursal disease during their first 2-4 weeks of life.
470
471			</p>
472			</div>
473
474
475
476
477
478
479
480
481
482
483
484
485			<div align="justify">
486			<p style="text-align: justify;">
487
488			<b></b>
489
490			</p>
491			</div>
492
493
494
495
496
497
498
499
500
501
502
503
504			<div align="justify">
505			<p style="text-align: justify;">
506
507			<b><i>Warnings and precautions</i></b><b></b>
508
509			</p>
510			</div>
511
512
513
514
515
516
517
518
519
520
521
522
523			<div align="justify">
524			<p style="text-align: justify;">
525
526			The vaccine is administered to all birds in the flock.
527
528			</p>
529			</div>
530
531
532
533
534
535
536
537
538
539
540
541
542			<div align="justify">
543			<p style="text-align: justify;">
544
545
546
547			</p>
548			</div>
549
550
551
552
553
554
555
556
557
558
559
560
561			<div align="justify">
562			<p style="text-align: justify;">
563
564			Once opened use within 24 hours.
565
566			</p>
567			</div>
568
569
570
571
572
573
574
575
576
577
578
579
580			<div align="justify">
581			<p style="text-align: justify;">
582
583
584
585			</p>
586			</div>
587
588
589
590
591
592
593
594
595
596
597
598
599			<div align="justify">
600			<p style="text-align: justify;">
601
602			Packaging and vaccine leftovers must be disposed in a safe way.
603
604			</p>
605			</div>
606
607
608
609
610
611
612
613
614
615
616
617
618			<div align="justify">
619			<p style="text-align: justify;">
620
621
622
623			</p>
624			</div>
625
626
627
628
629
630
631
632
633
634
635
636
637			<div align="justify">
638			<p style="text-align: justify;">
639
640			Avoid direct exposure to sunlight and high temperatures.
641
642			</p>
643			</div>
644
645
646
647
648
649
650
651
652
653
654
655
656			<div align="justify">
657			<p style="text-align: justify;">
658
659
660
661			</p>
662			</div>
663
664
665
666
667
668
669
670
671
672
673
674
675			<div align="justify">
676			<p style="text-align: justify;">
677
678			Beware of accidental injecting into the hand. In severe local reaction seek medical advice (surgeon).
679
680			</p>
681			</div>
682
683
684
685
686
687
688
689
690
691
692
693
694			<div align="justify">
695			<p style="text-align: justify;">
696
697
698
699			</p>
700			</div>
701
702
703
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705
706
707
708
709
710
711
712
713			<div align="justify">
714			<p style="text-align: justify;">
715
716			<b><i>Withdrawal</i></b>
717
718			</p>
719			</div>
720
721
722
723
724
725
726
727
728
729
730
731
732			<div align="justify">
733			<p style="text-align: justify;">
734
735			Meat, organs and other edible tissues of the vaccinated pullets - 0 days.
736
737			</p>
738			</div>
739
740
741
742
743
744
745
746
747
748
749
750
751			<div align="justify">
752			<p style="text-align: justify;">
753
754			<b></b>
755
756			</p>
757			</div>
758
759
760
761
762
763
764
765
766
767
768
769
770			<div align="justify">
771			<p style="text-align: justify;">
772
773			<b><i>Storage</i></b>
774
775			</p>
776			</div>
777
778
779
780
781
782
783
784
785
786
787
788
789			<div align="justify">
790			<p style="text-align: justify;">
791
792	dpavlin	1.2	Store in a dark place at 2-8°C (refrigerator). Keep away from children. Avoid freezing.
793	dpavlin	1.1
794			</p>
795			</div>
796
797
798
799
800
801
802
803
804
805
806
807
808			<div align="justify">
809			<p style="text-align: justify;">
810
811
812
813			</p>
814			</div>
815
816
817
818
819
820
821
822
823
824
825
826
827			<div align="justify">
828			<p style="text-align: justify;">
829
830			<b><i>Shelf life</i></b><b></b>
831
832			</p>
833			</div>
834
835
836
837
838
839
840
841
842
843
844
845
846			<div align="justify">
847			<p style="text-align: justify;">
848
849			Denoted on the packaging (18 months in the original pack).
850
851			</p>
852			</div>
853
854
855
856
857
858
859
860
861
862
863
864
865			<div align="justify">
866			<p style="text-align: justify;">
867
868
869
870			</p>
871			</div>
872
873
874
875
876
877
878
879
880
881
882
883
884			<div align="justify">
885			<p style="text-align: justify;">
886
887			<b><i>Legal category</i></b><b></b>
888
889			</p>
890			</div>
891
892
893
894
895
896
897
898
899
900
901
902
903			<div align="justify">
904			<p style="text-align: justify;">
905
906			On prescription only.
907
908			</p>
909			</div>
910
911
912
913
914
915
916
917
918
919
920
921
922			<div align="justify">
923			<p style="text-align: justify;">
924
925
926
927			</p>
928			</div>
929
930
931
932
933
934
935
936
937
938
939
940
941			<div align="justify">
942			<p style="text-align: justify;">
943
944			<b><i>Supply</i></b><b></b>
945
946			</p>
947			</div>
948
949
950
951
952
953
954
955
956
957
958
959
960			<div align="justify">
961			<p style="text-align: justify;">
962
963			Pierced bottle of 100 mL (200 doses) and 500 mL (1000 doses).
964
965			</p>
966			</div>
967
968
969
970
971
972
973
974
975
976
977
978
979			<div align="justify">
980			<p style="text-align: justify;">
981
982
983
984			</p>
985			</div>
986
987
988
989
990
991
992
993
994
995
996
997
998			<div align="justify">
999			<p style="text-align: justify;">
1000
1001			<b><i>Manufacturer</i></b><b></b>
1002
1003			</p>
1004			</div>
1005
1006
1007
1008
1009
1010
1011
1012
1013
1014
1015
1016
1017			<div align="justify">
1018			<p style="text-align: justify;">
1019
1020			VETERINA Animal Health Ltd., Croatia
1021
1022			</p>
1023			</div>
1024
1025
1026
1027
1028
1029
1030
1031
1032
1033
1034
1035
1036			<div align="justify">
1037			<p style="text-align: justify;">
1038
1039
1040
1041			</p>
1042			</div>
1043
1044
1045
1046
1047
1048
1049
1050
1051
1052
1053
1054
1055			<div align="justify">
1056			<p style="text-align: justify;">
1057
1058			<b><i>Important note</i></b><b></b>
1059
1060			</p>
1061			</div>
1062
1063
1064
1065
1066
1067
1068
1069
1070
1071
1072
1073
1074			<div align="justify">
1075			<p style="text-align: justify;">
1076
1077			Infectious bursal disease virus (Gumboro disease) affects bursa of Fabricius, which is an important part of the chicks' immune system. Its infection markedly affects the bird's resistance to infectious diseases, particularly if occurs during the first 2 weeks of hatching. Infected chicks may have reduced immune response to other avian vaccines.
1078
1079			</p>
1080			</div>
1081
1082
1083
1084
1085
1086
1087
1088
1089
1090
1091
1092
1093			<div align="justify">
1094			<p style="text-align: justify;">
1095
1096
1097
1098			</p>
1099			</div>
1100
1101
1102
1103
1104
1105
1106
1107
1108
1109
1110
1111
1112			<div align="justify">
1113			<p style="text-align: justify;">
1114
1115			In every animal population there are some with poorer response to vaccination. In addition to proper storage and administration, success of vaccination depends on hereditary factors, age of the animal, subclinical diseases, maternal antibodies, feed, stress factors and concurrent administration of other drugs.
1116
1117			</p>
1118			</div>
1119
1120
1121
1122
1123
1124
1125
1126
1127
1128
1129
1130
1131			<div align="justify">
1132			<p style="text-align: justify;">
1133
1134
1135
1136			</p>
1137			</div>
1138
1139
1140
1141
1142
1143
1144
1145
1146
1147
1148
1149
1150			<div align="left">
1151			<p style="text-align: left;">
1152
1153
1154
1155			</p>
1156			</div>
1157
1158
1159
1160
1161
1162
1163
1164			<!--Section Ends-->
1165
1166
1167
1168
1169
1170
1171
1172