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<p align="left"><font size="4" color="#FF9933"><b><font color="#000000" size="3">Development |
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of NCE`s</font></b></font></p> |
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<table width="90%" border="0" cellspacing="0" cellpadding="0" align="center"> |
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<tr> |
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<td height="10" width="19%"> |
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<div align="center"><b>PROJECT</b></div> |
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</td> |
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<td height="10" width="26%"> |
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<div align="center"><b>INDICATION</b></div> |
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</td> |
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<td height="10" width="24%"> |
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<div align="center"><b>STATUS</b></div> |
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</td> |
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<td height="10" width="31%"> |
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<div align="center"><b>MARKET POTENTIAL </b></div> |
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</td> |
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</tr> |
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</table> |
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<table width="90%" border="1" cellspacing="0" cellpadding="0" align="center"> |
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<tr> |
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<td width="19%"> |
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<div align="center">PLD - 116</div> |
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</td> |
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<td width="26%"> |
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<div align="center">Inflammatory Bowel Disease (IBD)</div> |
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</td> |
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<td width="24%"> |
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<div align="center">Preclinical Development</div> |
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</td> |
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<td width="31%"> |
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<div align="center">US$ 600 m. to US$ 1bn</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="19%"> |
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<div align="center">PLD - 117</div> |
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</td> |
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<td width="26%"> |
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<div align="center">Oncology<br> |
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Hematology</div> |
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</td> |
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<td width="24%"> |
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<div align="center">Preclinical Development</div> |
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</td> |
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<td width="31%"> |
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<div align="center">US$ 600-900 m.</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="19%"> |
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<div align="center">PLD - 118</div> |
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</td> |
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<td width="26%"> |
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<div align="center">Anti-fungal</div> |
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</td> |
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<td width="24%"> |
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<div align="center">Preclinical Development</div> |
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</td> |
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<td width="31%"> |
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<div align="center">US$ 600-800 m.</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="19%"> |
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<div align="center">PLR - 1</div> |
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</td> |
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<td width="26%"> |
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<div align="center">Anti-infective</div> |
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</td> |
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<td width="24%"> |
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<div align="center">Discovery</div> |
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</td> |
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<td width="31%"> |
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<div align="center">~ US$ 1 bn</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="19%"> |
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<div align="center">PLR - 13</div> |
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</td> |
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<td width="26%"> |
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<div align="center">Inflammation<br> |
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Asthma</div> |
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</td> |
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<td width="24%"> |
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<div align="center">Discovery</div> |
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</td> |
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<td width="31%"> |
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<div align="center">~ US$ 500 m.</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="19%"> |
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<div align="center">PLR - 9</div> |
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</td> |
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<td width="26%"> |
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<div align="center">Anti-infective</div> |
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</td> |
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<td width="24%"> |
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<div align="center">Discovery</div> |
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</td> |
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<td width="31%"> |
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<div align="center">~ US$ 1 bn</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="19%"> |
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<div align="center">PLR - 14</div> |
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</td> |
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<td width="26%"> |
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<div align="center">Inflammation<br> |
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RA, IBD</div> |
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</td> |
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<td width="24%"> |
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<div align="center">Discovery</div> |
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</td> |
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<td width="31%"> |
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<div align="center">~ US$ 1 bn </div> |
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</td> |
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</tr> |
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</table> |
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<table width="100%" border="0" cellspacing="3" cellpadding="0"> |
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<tr> |
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<td> |
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<hr size="1" width="100%"> |
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</td> |
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</tr> |
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</table> |
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<p><b>Development of Generics</b></p> |
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<table width="90%" align="center" border="0" cellspacing="0" cellpadding="0"> |
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<tr> |
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<td width="25%" height="35"> |
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<div align="center"><b>GENERIC PRODUCT</b></div> |
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</td> |
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<td width="23%" height="35"> |
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<div align="center"><b>FIRST REGISTRATION EXPECTED</b> </div> |
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</td> |
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<td width="25%" height="35"> |
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<div align="center"><b>GENERIC PRODUCT</b></div> |
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</td> |
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<td width="27%" height="35"> |
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<div align="center"><b>FIRST REGISTRATION EXPECTED</b></div> |
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</td> |
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</tr> |
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<tr> |
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<td colspan="4"> |
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<table width="100%" border="1" cellspacing="0" cellpadding="0"> |
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<tr> |
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<td width="25%">Simvastatin</td> |
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<td width="23%"> |
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<div align="center">2001</div> |
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</td> |
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<td width="25%">Losartan</td> |
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<td width="27%"> |
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<div align="center">2002</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Loratadin</td> |
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<td width="23%"> |
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<div align="center">2001</div> |
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</td> |
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<td width="25%">Carvedilol</td> |
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<td width="27%"> |
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<div align="center">2002</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Erythropoietin</td> |
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<td width="23%"> |
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<div align="center">2001</div> |
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</td> |
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<td width="25%">Bisoprolol</td> |
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<td width="27%"> |
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<div align="center">2003</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Warfarin</td> |
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<td width="23%"> |
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<div align="center">2001</div> |
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</td> |
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<td width="25%">Losartan+HCTZ</td> |
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<td width="27%"> |
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<div align="center">2003</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Diklofenac</td> |
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<td width="23%"> |
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<div align="center">2001</div> |
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</td> |
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<td width="25%">Clarithromycin</td> |
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<td width="27%"> |
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<div align="center">2003</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Ca folinat</td> |
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<td width="23%"> |
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<div align="center">2001</div> |
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</td> |
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<td width="25%">Venlafaxine</td> |
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<td width="27%"> |
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<div align="center">2003</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Ondansetron</td> |
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<td width="23%"> |
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<div align="center">2002</div> |
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</td> |
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<td width="25%">Interferon alpha</td> |
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<td width="27%"> |
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<div align="center">2003</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Torasemid</td> |
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<td width="23%"> |
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<div align="center">2002</div> |
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</td> |
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<td width="25%">Paroxetin</td> |
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<td width="27%"> |
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<div align="center">2003</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Amlodipin</td> |
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<td width="23%"> |
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<div align="center">2002</div> |
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</td> |
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<td width="25%">HGH</td> |
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<td width="27%"> |
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<div align="center">2003</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Risperidone</td> |
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<td width="23%"> |
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<div align="center">2002</div> |
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</td> |
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<td width="25%">Meloxicam</td> |
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<td width="27%"> |
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<div align="center">2003</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Alendronate</td> |
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<td width="23%"> |
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<div align="center">2002</div> |
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</td> |
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<td width="25%">Interferon beta</td> |
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<td width="27%"> |
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<div align="center">2004</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Ciprofloxacin</td> |
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<td width="23%"> |
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<div align="center">2002</div> |
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</td> |
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<td width="25%">Indapamide</td> |
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<td width="27%"> |
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<div align="center">2004</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">Mesalazin</td> |
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<td width="23%"> |
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<div align="center">2002</div> |
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</td> |
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<td width="25%">Cytostatics (9)</td> |
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<td width="27%"> |
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<div align="center">2001-2003</div> |
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</td> |
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</tr> |
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<tr> |
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<td width="25%">G-CSF </td> |
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<td width="23%"> |
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<div align="center">2002</div> |
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</td> |
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<td width="25%">OTC products (9)</td> |
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<td width="27%"> |
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<div align="center">2001-2003</div> |
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</td> |
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</tr> |
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</table> |
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</td> |
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</tr> |
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</table> |
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