| 1 |
dpavlin |
1.1 |
<p><b>Researching the Fight Against Infection</b></p> |
| 2 |
|
|
<p>PLIVA's anti-infectives research is being conducted in three separate programs: |
| 3 |
|
|
Macrolide research, New Antibiotics research, and Biodiversity discovery.</p> |
| 4 |
|
|
<p>With its internationally acknowledged insight into macrolide chemistry, as |
| 5 |
|
|
evidenced by its discovery of Azithromycin, PLIVA has entered into a strategic |
| 6 |
|
|
co-operation with GlaxoWellcome (with the merger of SmithKline and Glaxo a novel |
| 7 |
|
|
Joint Operating Committee is currently being set up) to identify a novel macrolide |
| 8 |
|
|
antibiotic for world-wide development and marketing. The goal of this venture |
| 9 |
|
|
is to identify a macrolide with improved efficacy, particularly against resistant |
| 10 |
|
|
strains of bacteria. The program is currently keeping pace with its ambitious |
| 11 |
|
|
plans and efforts are being focused on fine-tuning the derivatization process |
| 12 |
|
|
in order to enter the development phase within the next year.</p> |
| 13 |
dpavlin |
1.2 |
<p align="center"><img src="p/OKrnd_ljudi_7.jpg" width="300" height="202" border=1></p> |
| 14 |
dpavlin |
1.1 |
<p>The goal of PLIVA's second program is to find a novel anti-bacterial compound |
| 15 |
|
|
class showing no cross-resistance with current antibiotics. In cooperation with |
| 16 |
|
|
Althexis, Boston, USA, a company with leading expertise in structure-based drug |
| 17 |
|
|
design and crystallography, researchers from both companies have identified |
| 18 |
|
|
two novel scaffolds showing activity with <i>in vitro</i> and <i>in vivo</i> |
| 19 |
|
|
models of infections. One compound class with promising <i>in vitro</i> and |
| 20 |
|
|
<i>in vivo</i> activity is being further characterized in detail, and further |
| 21 |
|
|
studies into other species and the testing of improved compounds is ongoing. |
| 22 |
|
|
Other activities are focused on improving distinct scaffolds in iterative cycles |
| 23 |
|
|
reacting specifically with the chosen target. The specific activity of two scaffolds |
| 24 |
|
|
was confirmed experimentally, and the first compounds out of this series with |
| 25 |
|
|
antibacterial activity were identified. Various companies have already approached |
| 26 |
|
|
Althexis and PLIVA to participate in this program. A derivatization program |
| 27 |
|
|
to identify a developmental candidate within the shortest possible time has |
| 28 |
|
|
been fully established.</p> |
| 29 |
|
|
<p>As an extension of its anti-bacterial program, PLIVA has licensed-in a novel |
| 30 |
|
|
anti-fungal compound (PLD-118) from Bayer AG, Germany. This compound has demonstrated |
| 31 |
|
|
excellent efficacy against the most common systemic fungal infections as well |
| 32 |
|
|
as excellent tolerability and pharmacokinetic properties in various pre-clinical |
| 33 |
|
|
models. PLD-118 would represent the first novel, orally available compound class |
| 34 |
|
|
for the treatment of infections caused by the Candida yeast since the introduction |
| 35 |
|
|
of the azoles in the 1970s.The project has a novel mode of action and has strong |
| 36 |
|
|
potential to solve azole resistance problems.</p> |
| 37 |
|
|
<p>In the Biodiversity program, activities are being focused on generating the |
| 38 |
|
|
"toolbox" for the generation of novel enzymes and the application of the technology |
| 39 |
|
|
to streptomyces, one of the most important microbial organisms for the production |
| 40 |
|
|
of small molecules. Significant improvement of the general technology, which |
| 41 |
|
|
is currently patented, has been achieved. The Biodiversity program is conducted |
| 42 |
|
|
in both MIXIS France and PLIVA Zagreb laboratories, and it should give MIXIS |
| 43 |
|
|
a vehicle for future products, a far longer patent protection and simplified |
| 44 |
|
|
and attractive format. </p> |
Parent Directory
| 
Revision Log